Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 1216247..1216791 Replicon chromosome
Accession NZ_CP096040
Organism Caulobacter segnis strain RL271

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag MZV50_RS06000 Protein ID WP_252633508.1
Coordinates 1216247..1216540 (-) Length 98 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID -
Locus tag MZV50_RS06005 Protein ID WP_252635191.1
Coordinates 1216537..1216791 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MZV50_RS05965 (MZV50_05960) 1211310..1211528 + 219 WP_252633502.1 hypothetical protein -
MZV50_RS05970 (MZV50_05965) 1211533..1212300 - 768 WP_252633503.1 DUF3108 domain-containing protein -
MZV50_RS05975 (MZV50_05970) 1212415..1212939 - 525 Protein_1182 AAA family ATPase -
MZV50_RS05980 (MZV50_05975) 1212995..1213531 - 537 WP_252633504.1 GNAT family N-acetyltransferase -
MZV50_RS05985 (MZV50_05980) 1213632..1214174 + 543 WP_252633505.1 methyltransferase domain-containing protein -
MZV50_RS05990 (MZV50_05985) 1214178..1215389 - 1212 WP_252633506.1 YihY/virulence factor BrkB family protein -
MZV50_RS05995 (MZV50_05990) 1215482..1216243 + 762 WP_252633507.1 MOSC domain-containing protein -
MZV50_RS06000 (MZV50_05995) 1216247..1216540 - 294 WP_252633508.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MZV50_RS06005 (MZV50_06000) 1216537..1216791 - 255 WP_252635191.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
MZV50_RS06010 (MZV50_06005) 1216875..1217744 + 870 WP_252633509.1 peptide chain release factor N(5)-glutamine methyltransferase -
MZV50_RS06015 (MZV50_06010) 1217782..1217993 + 212 Protein_1190 hypothetical protein -
MZV50_RS06020 (MZV50_06015) 1217990..1219111 + 1122 WP_252633510.1 DUF4167 domain-containing protein -
MZV50_RS06025 (MZV50_06020) 1219317..1219730 - 414 WP_252633511.1 arsenate reductase (glutaredoxin) -
MZV50_RS06030 (MZV50_06025) 1219727..1220401 - 675 WP_252633512.1 MIP/aquaporin family protein -
MZV50_RS06035 (MZV50_06030) 1220404..1220760 - 357 WP_252633513.1 helix-turn-helix transcriptional regulator -
MZV50_RS06040 (MZV50_06035) 1220815..1221546 + 732 WP_252633514.1 arsenical resistance protein ArsH -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin

Antitoxin ParD

(2-79)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 11321.76 Da        Isoelectric Point: 9.4743

>T242729 WP_252633508.1 NZ_CP096040:c1216540-1216247 [Caulobacter segnis]
VSGYRLTPRAQRDFDEIWVYSRAQWGARRALSYLQDIRATIGLVAANPDLSPINDDLPNGYRQRSAGSHFIFYKRRETFI
EIVRILHQNMDIESHLS

Download         Length: 294 bp

>T242729 NZ_OW967003:c2506709-2506332 [Escherichia coli]
ATGAACACATTACCCGATACACACGTACGGGAGGCATCGCATTGCCAGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCATTACGGCCTCACACTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACTCGTTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCCCGCCGGGCAACCGGCCTGATGGCCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAACATCCGGGGGCGAAACAATGA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9460.53 Da        Isoelectric Point: 4.2156

>AT242729 WP_252635191.1 NZ_CP096040:c1216791-1216537 [Caulobacter segnis]
VMSKNTSIVLSEHFQSFISDQIEEGRYGSASEVVRAGLRLLEDREMRLARLRAALIEGEQSGLAEEFDLDAYIAEKAREE
GIEE

Download         Length: 255 bp

>AT242729 NZ_OW967003:c2507167-2506799 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACGCTTCCCGACGACAATAACGACCGCACCTGGTGGGGACTGCCCTGCACCGTGAC
GCCCTGTTTTGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCAGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATGCGTACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAAGGCTGACCTGCGAAGCCGACACCCTCGGCAGTTG
TGGCTACGTTTATATGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References