Detailed information of TA system TA242727

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/CC2985(antitoxin)
• Location: 210828..211353
• Replicon: chromosome
• Accession: NZ_CP096040
• Organism: Caulobacter segnis strain RL271

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: MZV50_RS01090
• Protein ID: WP_252632564.1
• Coordinates: 210828..211112 (-)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: -
• Locus tag: MZV50_RS01095
• Protein ID: WP_252632566.1
• Coordinates: 211102..211353 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MZV50_RS01060 (MZV50_01060)	206845..207672	-	828	WP_252632554.1	protein-glutamate O-methyltransferase CheR	-
MZV50_RS01065 (MZV50_01065)	207669..208046	-	378	WP_252632555.1	response regulator	-
MZV50_RS01070 (MZV50_01070)	208149..208826	-	678	WP_252632557.1	histidine phosphotransferase ChpT	-
MZV50_RS01075 (MZV50_01075)	208891..209082	+	192	WP_252632558.1	DUF3553 domain-containing protein	-
MZV50_RS01080 (MZV50_01080)	209093..209884	+	792	WP_252632560.1	3'(2'),5'-bisphosphate nucleotidase CysQ	-
MZV50_RS01085 (MZV50_01085)	209922..210794	-	873	WP_252632562.1	DMT family transporter	-
MZV50_RS01090 (MZV50_01090)	210828..211112	-	285	WP_252632564.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
MZV50_RS01095 (MZV50_01095)	211102..211353	-	252	WP_252632566.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
MZV50_RS01100 (MZV50_01100)	211451..211807	-	357	WP_223392274.1	DUF1318 domain-containing protein	-
MZV50_RS01105 (MZV50_01105)	211823..212008	-	186	WP_252632567.1	YnbE family lipoprotein	-
MZV50_RS01110 (MZV50_01110)	212044..213609	-	1566	WP_252632568.1	YdbH domain-containing protein	-
MZV50_RS01115 (MZV50_01115)	213648..215294	-	1647	WP_252632569.1	hypothetical protein	-
MZV50_RS01120 (MZV50_01120)	215346..216134	-	789	WP_252632571.1	4-hydroxy-tetrahydrodipicolinate reductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-90)

Antitoxin

• Antitoxin ParD (3-70)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 10904.24 Da
• Isoelectric Point: 6.0786

>T242727 WP_252632564.1 NZ_CP096040:c211112-210828 [Caulobacter segnis]
VAYRLSRKAEDDIIQIYVSGAEMFGPEQAERYHEGLEQTFAFLSDFPFAATERPELRGARVHPYKSHIIVYRLDRGDILV
QRVRHASEDWVGQP

Nucleotide

• Length: 285 bp

>T242727 NZ_OW967003:c2069923-2069525 [Escherichia coli]
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAACTTGATGCGTTAACAGCGGATTTTATTTC
CTATAAGCGTGACGGTGTTTTGCCAGATATATTTGGTCGCGATGCACTCTACGACGACTCGTTTACCTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGTGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGAAGCGCATTTGGTATATTGTCAGGGTGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAACCTGA
ACCTCATAAACTGGCTCGAGATAACAACCAAATGCATAAAATTGGGAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9212.40 Da
• Isoelectric Point: 5.1617

>AT242727 WP_252632566.1 NZ_CP096040:c211353-211102 [Caulobacter segnis]
MATMNVSLPDAMKAWVEEQAGTGRYSNASDYVRDLIRRDQERADKIAAMQRLIEEAEESGVSPRSMSEVLAAARLKAAER
RGV

Nucleotide

• Length: 252 bp

>AT242727 NZ_OW967003:c2070219-2069926 [Escherichia coli]
ATGCATCGAATTCTCGCTGAAAAATCGGTCAATATCACTGAGTTACGTAAAAACCCAGCTAAATACTTTATTGATCAACC
GGTTGCGGTTCTTTCTAATAATCGCCCCGCAGGATATCTCTTAAGTGCCAGCGCATTTGAAGCGTTAATGGACATGCTTG
CTGAACAAGAGGAGAAAAAACTGGTTAAGGCGCGCTTCCGTCCGAGTGCCGCAAGATTAGAGGAAATTACACGCCGCGCT
GAACAATATCTTAATGATATGACGGATGATGATTTCAATGACTTTAAGGAATAA