Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-dinJ/YafQ-RelB
Location 310390..310921 Replicon plasmid unnamed4
Accession NZ_CP096039
Organism Rhodococcus pyridinivorans strain Y6

Toxin (Protein)


Gene name relE Uniprot ID I2ALI9
Locus tag MX572_RS26305 Protein ID WP_011114071.1
Coordinates 310640..310921 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID I2ALI8
Locus tag MX572_RS26300 Protein ID WP_011114070.1
Coordinates 310390..310653 (+) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MX572_RS26275 (MX572_26260) 306723..307169 - 447 WP_254584706.1 LuxR C-terminal-related transcriptional regulator -
MX572_RS26285 (MX572_26270) 308315..309514 - 1200 Protein_256 klcB -
MX572_RS26290 (MX572_26275) 309526..309744 - 219 WP_012478187.1 hypothetical protein -
MX572_RS26295 (MX572_26280) 309789..310217 - 429 WP_011114069.1 antirestriction protein -
MX572_RS26300 (MX572_26285) 310390..310653 + 264 WP_011114070.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
MX572_RS26305 (MX572_26290) 310640..310921 + 282 WP_011114071.1 type II toxin-antitoxin system YafQ family toxin Toxin
MX572_RS26310 (MX572_26295) 312266..312505 - 240 Protein_261 Tn3 family transposase -
MX572_RS26315 (MX572_26300) 312649..313470 - 822 Protein_262 Tn3 family transposase -
MX572_RS26320 (MX572_26305) 313502..314470 - 969 WP_254583916.1 IS3 family transposase -
MX572_RS26325 (MX572_26310) 314467..314757 - 291 WP_254583917.1 transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..331002 331002


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(1-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-83)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10743.19 Da        Isoelectric Point: 7.4750

>T242726 WP_011114071.1 NZ_CP096039:310640-310921 [Rhodococcus pyridinivorans]
MRQIERTGQFKRDYKREAKGQHRATLDADLVPVLVALADDQPLEPRHRDHALTGDWKDHRDCHVKPDLVLIYQKPDADTL
RLVRLGSHSELGL

Download         Length: 282 bp

>T242726 NZ_OW967003:1874034-1874252 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACTATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 9255.82 Da        Isoelectric Point: 5.7905

>AT242726 WP_011114070.1 NZ_CP096039:310390-310653 [Rhodococcus pyridinivorans]
MAANQLVQTRIDGAIKEEAAAVLAAMGLTVSDAVRLLLTKVAQDKALPFEPLIPNATTIEAMKEARKGKLPRFATVNDLM
ADLHAAD

Download         Length: 264 bp

>AT242726 NZ_OW967003:1873634-1874008 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGCAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1U9V4I5

Antitoxin

Source ID Structure
AlphaFold DB A0A1U9V3I2

References