Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazF-pemI/MazF(toxin)
Location 241468..242104 Replicon chromosome
Accession NZ_CP096034
Organism Gottfriedia acidiceleris strain LH14

Toxin (Protein)


Gene name mazF Uniprot ID A0A8J3ATI3
Locus tag MY490_RS01280 Protein ID WP_056476047.1
Coordinates 241754..242104 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID A0A8J3API8
Locus tag MY490_RS01275 Protein ID WP_069033898.1
Coordinates 241468..241749 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MY490_RS01255 (MY490_01255) 237292..238257 + 966 WP_248267664.1 UV DNA damage repair endonuclease UvsE -
MY490_RS01260 (MY490_01260) 238283..238636 + 354 WP_248267665.1 holo-ACP synthase -
MY490_RS01265 (MY490_01265) 238969..239988 + 1020 WP_248267666.1 outer membrane lipoprotein-sorting protein -
MY490_RS01270 (MY490_01270) 240157..241323 + 1167 WP_248267667.1 alanine racemase -
MY490_RS01275 (MY490_01275) 241468..241749 + 282 WP_069033898.1 antitoxin endoai Antitoxin
MY490_RS01280 (MY490_01280) 241754..242104 + 351 WP_056476047.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
MY490_RS01285 (MY490_01285) 242222..244420 + 2199 WP_248267668.1 Tex family protein -
MY490_RS01290 (MY490_01290) 244410..244520 - 111 WP_248269293.1 cortex morphogenetic protein CmpA -
MY490_RS01295 (MY490_01295) 244823..245275 + 453 WP_248267669.1 SprT family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-111)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12963.95 Da        Isoelectric Point: 4.6805

>T242723 WP_056476047.1 NZ_CP096034:241754-242104 [Gottfriedia acidiceleris]
MIVKRGDVYFADLSPVVGSEQGGVRPVLIIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAKKYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMDQVDEALQISLGLVDF

Download         Length: 351 bp

>T242723 NZ_OW967003:1202254-1202748 [Escherichia coli]
ATGATTCAGGCCCCCGAGCCACTCATGGCAAGGCATCAATTCACCTCTTTTTGCTCGGGAGTAGAAACGATGGATAACTG
GCTAAAGCAGAGAGCCCTAAAAAATCAGCTTGCCGGCGCATCACGTACATTTGTTAGCTGTGATACGTATAGCAACGTTT
TGGCATATTATTCGCTTGCTTCCAGCGCCGTTGAAACGTATGTCGCGACAGGACGATTTCGCCGAAATATGCCAGAACCG
ATCCCTGTTGTAGTACTTGGTCGTCTGGCAATAGATAAATCATTACAGGGTCAGGGCATCGGTCGTGCGATGGTCAGAGA
TGCCGGTCTACGAGTACTACAGGCGGCTGAAGTCATTGGTATTCGCGGAATGTTGGTCCATGCGTTATCAGACCAGGCCC
GTGAGTTTTATCTGCGAGTGGGGTTTGAACCATCGCCTGTCGATTCTATGATACTGATGGCAACATTGGCTGATTTGCAG
GAATGTCTTAAATAG

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10788.26 Da        Isoelectric Point: 9.4370

>AT242723 WP_069033898.1 NZ_CP096034:241468-241749 [Gottfriedia acidiceleris]
MSELNATTEITVRLPKHVVSELDGLVKQENGNRNEYIYQATKMFLKDRKRRQSREQMRRGYMEMAKINLLISSESFYAES
EADSKVERLVSGG

Download         Length: 282 bp

>AT242723 NZ_OW967003:1201964-1202257 [Escherichia coli]
ATGGCAGCAGCCAATAACATTCCAGCCAGGCGCGAATCTTTAAACTTGCGCATAAAACCCGCAGAACGCGATCTTATAGA
CCGGGCCGCTAAAGCCCGAGGAAAAAATCGCTCCGAATTTGTCCTTGAGGCCGCCAGAGCCGCAGCTGAAGAGGCGCTCA
TTGAGCAGAGAATTTTCAGGATCGATTCTGATGATTACCAGCTATTTTTGAATCGTCTGGATCAGCCCCCCGCGCCCAAT
GCTGCATTACGCAAAACCATGCAAACACCCGCGCCGTGGGAGCAAAAAAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References