Detailed information of TA system TA242720

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 975369..976042
• Replicon: chromosome
• Accession: NZ_CP096032
• Organism: Synechococcus sp. A10-1-5-1

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: MY494_RS05270
• Protein ID: WP_247911676.1
• Coordinates: 975608..976042 (+)
• Length: 145 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: MY494_RS05265
• Protein ID: WP_247911675.1
• Coordinates: 975369..975608 (+)
• Length: 80 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MY494_RS05245 (MY494_05245)	970817..972907	+	2091	WP_247911672.1	PBP1A family penicillin-binding protein	-
MY494_RS05250 (MY494_05250)	972904..974229	-	1326	WP_247911673.1	16S rRNA (cytosine(967)-C(5))-methyltransferase	-
MY494_RS05255 (MY494_05255)	974226..974558	-	333	WP_247911674.1	MGMT family protein	-
MY494_RS05260 (MY494_05260)	974609..975304	+	696	WP_247911968.1	tRNA (guanosine(18)-2'-O)-methyltransferase TrmH	-
MY494_RS05265 (MY494_05265)	975369..975608	+	240	WP_247911675.1	CopG family transcriptional regulator	Antitoxin
MY494_RS05270 (MY494_05270)	975608..976042	+	435	WP_247911676.1	PIN domain-containing protein	Toxin
MY494_RS05275 (MY494_05275)	976046..976945	-	900	WP_247911677.1	ABC transporter permease	-
MY494_RS05280 (MY494_05280)	976966..977679	+	714	WP_247911678.1	response regulator transcription factor	-
MY494_RS05285 (MY494_05285)	977676..978029	+	354	WP_247911679.1	response regulator	-
MY494_RS05290 (MY494_05290)	978016..979476	-	1461	WP_247911680.1	HAMP domain-containing sensor histidine kinase	-
MY494_RS13200	979673..979813	+	141	Protein_1044	type II secretion system GspH family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (7-131)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 145 a.a.
• Molecular weight: 15700.96 Da
• Isoelectric Point: 7.0233

>T242720 WP_247911676.1 NZ_CP096032:975608-976042 [Synechococcus sp. A10-1-5-1]
MAKATALLDVNVLIALLDPQHVHHELCHGWFASRGDAPWASCAITQNAVLRILGNPRYPNSPGPPASVAPHLDSLVGHPN
HQFWESNPSLLGQPFIERSALVDHAQITDLYLLALAKHHGGTLATLDQRIQVKKGEQGLELIRP

Nucleotide

• Length: 435 bp

>T242720 NZ_OW967003:715323-715499 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTAAAACTGAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin

Protein

• Length: 80 a.a.
• Molecular weight: 8660.86 Da
• Isoelectric Point: 10.7279

>AT242720 WP_247911675.1 NZ_CP096032:975369-975608 [Synechococcus sp. A10-1-5-1]
MRTTLSLDDDVLAAAKVLARQRKQPIGSVISDLAREGLAQANRKNQETPKARRNGLALLPRRADGSPVDLELVNSLRED

Nucleotide

• Length: 240 bp

>AT242720 NZ_OW967003:715545-715961 [Escherichia coli]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
CCAGGGCGAAACAGTTGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCGTTACCTTCGCCATTAAACAGTCACGATCACTTTATTGAAGTGCCTTTGAGCGTCGCCTCTAAAGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAGGAGAT
TACTCGCCTATTTAATTTGCACCATGCGACAAAAATCGACGCCGTCCAGCTCGCGGCTAAGGCGCTTGGCAAAGAGTTAT
CACTGGTGATGGTTTAA