Detailed information of TA system TA242718

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): chpSB/PRK09812-MazE
• Location: 2925190..2925791
• Replicon: chromosome
• Accession: NZ_CP096018
• Organism: Alkalimarinus coralli strain SCSIO 12817

Toxin (Protein)

• Gene name: chpB
• Uniprot ID: -
• Locus tag: MY525_RS13340
• Protein ID: WP_250656371.1
• Coordinates: 2925190..2925540 (-)
• Length: 117 a.a.

Antitoxin (Protein)

• Gene name: chpS
• Uniprot ID: -
• Locus tag: MY525_RS13345
• Protein ID: WP_250656372.1
• Coordinates: 2925534..2925791 (-)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MY525_RS13305	2920190..2921212	-	1023	WP_250656364.1	amino acid ABC transporter substrate-binding protein	-
MY525_RS13310	2921456..2922073	+	618	WP_250656365.1	GNAT family N-acetyltransferase	-
MY525_RS13315	2922066..2922749	+	684	WP_250656366.1	DTW domain-containing protein	-
MY525_RS13320	2922736..2923692	+	957	WP_250656367.1	NADP-dependent oxidoreductase	-
MY525_RS13325	2923734..2924144	+	411	WP_250656368.1	CBS domain-containing protein	-
MY525_RS13330	2924334..2924807	+	474	WP_250656369.1	YbaK/EbsC family protein	-
MY525_RS13335	2924865..2925188	+	324	WP_250656370.1	hypothetical protein	-
MY525_RS13340	2925190..2925540	-	351	WP_250656371.1	type II toxin-antitoxin system ChpB family toxin	Toxin
MY525_RS13345	2925534..2925791	-	258	WP_250656372.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
MY525_RS13350	2926207..2926881	-	675	WP_250656373.1	hypothetical protein	-
MY525_RS13355	2927036..2928793	-	1758	WP_250656374.1	sodium:proton antiporter	-
MY525_RS13360	2928980..2929759	-	780	WP_250656375.1	tRNA cyclic N6-threonylcarbamoyladenosine(37) synthase TcdA	-
MY525_RS13365	2929994..2930572	+	579	WP_250656376.1	CoA pyrophosphatase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (9-114)

Antitoxin

• SpoVT-AbrB domain (6-50)

Sequences

Toxin

Protein

• Length: 117 a.a.
• Molecular weight: 12531.71 Da
• Isoelectric Point: 10.1838

>T242718 WP_250656371.1 NZ_CP096018:c2925540-2925190 [Alkalimarinus coralli]
MVRRKQFDRGDIVKVSLNPVVGREMQGNFRPCMVLSPAAFNRLGTALVAPITQGGDFARVKGFAVPLIGSGTETQGVMLV
NAVRMLDLEGRQAKKVEVAPQEIVDDVLARLAAIIE

Nucleotide

• Length: 351 bp

>T242718 NZ_OW849529:79818-80348 [Citrobacter freundii]
ATGGAGGGTTTAAGGATTGAGATTTTTTCAGAGGAAGTTGAATATGAATTAAGCAACTTCGATTGTGGAGAAGAGTATCT
GAATACTTTTCTTACTGACCATCTGAAACGGCAGCATAACAGTAAGATCTTACGTGGTTATGTTCTCGTGACGAGAGAGA
ATAAACCGCGTGTGATGGGGTACTACACGCTATCAGGAAGTTGCTTTGAGAAAATACTTCTACCCAGCAAAACACAACAA
AAGCGTGTACCCTACAAGAATGTGCCGAGCGTGACTTTGGGCCGTCTGGCAATTGATAAAAGCATTCACCACCAGGGATA
TGGAGAAACACTTGTTACCCATGCGATGAAAGTCGTGTATCAGGCCTCGCAGGCTGTGGGTATACACGGAATGTTCGTGG
AAGCGCTGAACGACAACGCCAAAAAATTCTACCTTCGACTGGGTTTCATTCAGTTAAAGGAAGAAAACTGTAACTCGCTC
TTTTACCCGACAAAATCTATTGAAGAATTGTTCGAAGTAAATGATGAATAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9579.04 Da
• Isoelectric Point: 4.8779

>AT242718 WP_250656372.1 NZ_CP096018:c2925791-2925534 [Alkalimarinus coralli]
MRTTIRKIGNSAGAILPATVLKKLNLSEGDVIEVSEDGKRIVIEPRNEKPKYSLTELMAQCDEKAPLPKELEEWNDMQPT
GKEVW

Nucleotide

• Length: 258 bp

>AT242718 NZ_OW849529:79545-79814 [Citrobacter freundii]
ATGTCAGCACTGAAAAAGCAGCGCATTGACCTGAGATTAAATGAAGACGACAAACACATGATCGAAGAAGCTGCAGCAAT
GACTAACCAGTCAATTTCGCAGTTCATGGTCAGTACCGCCTCAGAACGCGCTGCAGAAGTTATTGACCAGCACCGTCGTC
TGCTCCTCAATGAGGAGTCTTGGAACCTGGTTATGGATGCAATCATTAATCCGCCAGCACCGAATGACCGGCTGAAACGC
GCCGCTAACCGTCTCCGGGAACTGGAGTAA