Detailed information of TA system TA242717

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relE-yefM/YoeB-YefM
• Location: 2914730..2915235
• Replicon: chromosome
• Accession: NZ_CP096018
• Organism: Alkalimarinus coralli strain SCSIO 12817

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: MY525_RS13260
• Protein ID: WP_250656356.1
• Coordinates: 2914730..2914987 (-)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: MY525_RS13265
• Protein ID: WP_250656357.1
• Coordinates: 2914984..2915235 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MY525_RS13235	2910202..2911179	+	978	WP_250656351.1	putative DNA binding domain-containing protein	-
MY525_RS13240	2911268..2913331	-	2064	WP_250656352.1	MFS transporter	-
MY525_RS13245	2913551..2913916	-	366	WP_250656353.1	type II toxin-antitoxin system RelE/ParE family toxin	-
MY525_RS13250	2913921..2914187	-	267	WP_250656354.1	hypothetical protein	-
MY525_RS13255	2914321..2914503	+	183	WP_250656355.1	hypothetical protein	-
MY525_RS13260	2914730..2914987	-	258	WP_250656356.1	Txe/YoeB family addiction module toxin	Toxin
MY525_RS13265	2914984..2915235	-	252	WP_250656357.1	YoeB-YefM toxin-antitoxin system antitoxin YefM	Antitoxin
MY525_RS13270	2915721..2915987	+	267	WP_250656358.1	ribbon-helix-helix protein, CopG family	-
MY525_RS13275	2915984..2916271	+	288	WP_250656359.1	type II toxin-antitoxin system RelE/ParE family toxin	-
MY525_RS13280	2916349..2916606	+	258	WP_250656360.1	hypothetical protein	-
MY525_RS13285	2916671..2916811	+	141	WP_250656361.1	hypothetical protein	-
MY525_RS13290	2916997..2917725	-	729	WP_250658854.1	amino acid ABC transporter ATP-binding protein	-
MY525_RS13295	2917780..2918886	-	1107	WP_250656362.1	amino acid ABC transporter permease	-
MY525_RS13300	2918897..2920108	-	1212	WP_250656363.1	ABC transporter permease subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-74)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 10246.82 Da
• Isoelectric Point: 10.0297

>T242717 WP_250656356.1 NZ_CP096018:c2914987-2914730 [Alkalimarinus coralli]
MKVTFSSAAWDQYLYWQTTDKKILKRINQLIKDIKREPYEGIGKPEPLKHGLAGYWSRRINDEHRIVYKYTEGTILIAQL
RYHYT

Nucleotide

• Length: 258 bp

>T242717 NZ_OW849529:c73911-73429 [Citrobacter freundii]
GTGGGACGTATAACCACGCCCGAGCCGTTATCCAGCTCTCATCAGCTGGCTGAGTTCGTCAGTGGAGAGACAGTCCTCGA
TGAATGGCTAAAACAGAGAGGTTTAAAAAATCAAGCTCTTGGCGCTGCCCGAACGTTCGTTGTTTGCAAGACGGGTACGA
AGCAAGTAGCTGGTTTTTACTCTTTGGCCACCGGTAGCGTTAACCATACGGAAGCGACAGGTAGTCTTCGGCGTAACATG
CCAGATCCTATACCGGTGATTATACTCGCTCGCCTGGCGGTAGATGTCTCATTGCACGGAAAAGGGGTTGGCGCCGATTT
ACTCCACGATGCAGTGCTACGGTGTTATCGCGTAGCTGAGAACATTGGGGTTCGTGCGATAATGGTTCATGCGCTTACTG
AAGAAGCCAAAGGTTTCTATGCTCACCATGGATTTAAGGCATCACAAACTCATGAGAGGACTCTGTTTCTAAAGCTTCCA
TGA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9316.54 Da
• Isoelectric Point: 4.4737

>AT242717 WP_250656357.1 NZ_CP096018:c2915235-2914984 [Alkalimarinus coralli]
MDAISYTHARANLSSTMEKVCNDHAPIIITRKSESPVVMMSLEDYQAMEETTYLLRSPANARQLLESIAELESGKGTERE
LLE

Nucleotide

• Length: 252 bp

>AT242717 NZ_OW849529:c74165-73899 [Citrobacter freundii]
ATGAAATCAGATGTTCAACTCAACCTAAGAGCTAAAGAGTCTCAGAGAGCACTCATCGATGCTGCTGCAGAGATCCTTCA
TAAATCGCGAACCGACTTTATCCTGGAGATGGCCTGCAAGGCTGCGGAGAATGTGATCCTTGATCGCCGTGTTTTCAATT
TTAACGACGAACAGTATGCAGAGTTCATCGATATGCTCGATGCACCAGTCGAGGATGAGCCCGCCATTAATAAACTACTG
GCAAGGAAACCTCAGTGGGACGTATAA