Detailed information of TA system TA242716

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 2766678..2767203
• Replicon: chromosome
• Accession: NZ_CP096018
• Organism: Alkalimarinus coralli strain SCSIO 12817

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: MY525_RS12490
• Protein ID: WP_250656208.1
• Coordinates: 2766919..2767203 (+)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: MY525_RS12485
• Protein ID: WP_250656207.1
• Coordinates: 2766678..2766929 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MY525_RS12455	2762204..2763112	-	909	WP_250656201.1	LysR family transcriptional regulator	-
MY525_RS12460	2763281..2764000	+	720	WP_250656202.1	glutathione S-transferase family protein	-
MY525_RS12465	2764220..2764885	+	666	WP_250656203.1	SDR family oxidoreductase	-
MY525_RS12470	2764977..2765231	+	255	WP_250656204.1	hypothetical protein	-
MY525_RS12475	2765265..2765918	-	654	WP_250656205.1	CBS domain-containing protein	-
MY525_RS12480	2766085..2766450	-	366	WP_250656206.1	YbaN family protein	-
MY525_RS12485	2766678..2766929	+	252	WP_250656207.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
MY525_RS12490	2766919..2767203	+	285	WP_250656208.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
MY525_RS12495	2767291..2768823	-	1533	WP_250656209.1	methyl-accepting chemotaxis protein	-
MY525_RS12500	2769019..2769513	+	495	WP_250656210.1	peptidylprolyl isomerase	-
MY525_RS12505	2769729..2770136	+	408	WP_250656211.1	GFA family protein	-
MY525_RS12510	2770222..2771250	+	1029	WP_250656212.1	DUF2157 domain-containing protein	-
MY525_RS12515	2771325..2771987	+	663	WP_250656213.1	YoaK family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-82)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (11-77)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 10847.91 Da
• Isoelectric Point: 10.7024

>T242716 WP_250656208.1 NZ_CP096018:2766919-2767203 [Alkalimarinus coralli]
MTYKLKFLPAALKEWKKLASPIQSQFKKKLSERLENPRVPSAKLSGFDSVYKIKLRTAGYRLAYEVVDDEVVVYVLVVGK
RDKGKVYQKLKGRI

Nucleotide

• Length: 285 bp

>T242716 NZ_OW849528:c168788-168330 [Citrobacter freundii]
GTGATCCTTTACCGACTGACCAAGACCCGTTATCTGATGACTGCGTGGTCTGGTCTGGGTGCGAAAGAAGCGGGGGGCCG
CTGGAACAGCGTAGGCACTGCAATGGTCTACCTGTCTGAAACGGCCAGCCTTACCATGCTTGAAACGCTGGTACACATTC
ACGCGCCGCAGTTACTGGACGACTTTACACTGCTGAGTCTTGATGTACCGGATGATCAGATCCAGACCTTCGACATGAGC
CGTCTCCCTGATAACTGGGCGAGTGAGGATGCTCCTGCTGAGCTGGCGCTCTACGGTGATAACTGGGCTGAAAGCGGTTC
TTCTATCGCGCTGCGTATTCCAAGTGCGTTGTCTCCGGTTGAATTTAACTACTTGCTGAATCCGGCACACCCTGAACTCT
TTGACCTGATGGCTACGGTTAAGAAAATTCCGTTCCGGTTTGATTCCCGCCTGAAATAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9152.48 Da
• Isoelectric Point: 4.2813

>AT242716 WP_250656207.1 NZ_CP096018:2766678-2766929 [Alkalimarinus coralli]
MRQVLADCSASISELKKNPTALLNESAGAPIAILNHNKPAAYLVPAETYEWLMDMLDDQELAKLVEQRVAKKDQAVEVSL
DDL

Nucleotide

• Length: 252 bp

>AT242716 NZ_OW849528:c169231-168785 [Citrobacter freundii]
ATGACGATGAAAGTTTTTTCTCCAGACGTTACCAAAACGAATCAGCACTGCTTATGGCAGGTTGCTGGGCTGGATAATGA
CGGTATCGCGCTGATGGATAAAATCAATCACGGTCTCGATGGCACAGTAGCTAAGCACATTTCTGAATGGGCTAACATCA
CGCCGTCTGAGCTGCGCAAAATGTCGGGTATACCTAATACGACGTTTAATCGTAGCATCAAAGACCGTTTCACTGCCGAT
CAGAGCGAACGTCTGGTGCGCATTATCCGCGTAATTGAACGCGCTGTAGAGCTGTTTGAAGGTGACAAAGAAGCGGCGCA
CAAATGGCTGAACGAAGCGAACCGTGGTCTGAGCTGGAAATCACCGGCAGAGCTTGTTTCTTCTGAGACAGGTGCGCTTG
AAGTGATGCGCCTGATTACGCGTATTGAGCACGGGGTATACTCGTGA