Detailed information of TA system TA242713

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /BrnT(toxin)
• Location: 1201119..1201623
• Replicon: chromosome
• Accession: NZ_CP096018
• Organism: Alkalimarinus coralli strain SCSIO 12817

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: MY525_RS05320
• Protein ID: WP_250654860.1
• Coordinates: 1201360..1201623 (-)
• Length: 88 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: MY525_RS05315
• Protein ID: WP_250654859.1
• Coordinates: 1201119..1201370 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MY525_RS05285	1196221..1197240	+	1020	WP_250654853.1	PhoH family protein	-
MY525_RS05290	1197237..1197719	+	483	WP_250654854.1	rRNA maturation RNase YbeY	-
MY525_RS05295	1197716..1198558	+	843	WP_250654855.1	transporter associated domain-containing protein	-
MY525_RS05300	1198657..1200285	+	1629	WP_250654856.1	apolipoprotein N-acyltransferase	-
MY525_RS05305	1200481..1200792	-	312	WP_250654857.1	type II toxin-antitoxin system RelE/ParE family toxin	-
MY525_RS05310	1200780..1201037	-	258	WP_250654858.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
MY525_RS05315	1201119..1201370	-	252	WP_250654859.1	CopG family transcriptional regulator	Antitoxin
MY525_RS05320	1201360..1201623	-	264	WP_250654860.1	BrnT family toxin	Toxin
MY525_RS05325	1202169..1202405	+	237	WP_250654861.1	addiction module protein	-
MY525_RS05330	1202410..1202721	+	312	WP_250654862.1	type II toxin-antitoxin system RelE/ParE family toxin	-
MY525_RS05335	1202982..1203284	-	303	WP_250654863.1	hypothetical protein	-
MY525_RS05340	1203281..1203559	-	279	WP_250654864.1	BrnT family toxin	-
MY525_RS05345	1204150..1204620	-	471	WP_250654865.1	GNAT family N-acetyltransferase	-
MY525_RS05350	1204718..1206049	-	1332	WP_250654866.1	group II intron reverse transcriptase/maturase	-
MY525_RS05355	1206085..1206249	-	165	WP_250654867.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integron	-	-	1198657..1203284	4627

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Ribonuclease toxin, BrnT, of type II toxin-antitoxin system (6-81)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 88 a.a.
• Molecular weight: 10120.37 Da
• Isoelectric Point: 6.7196

>T242713 WP_250654860.1 NZ_CP096018:c1201623-1201360 [Alkalimarinus coralli]
MYNFEFDHKKSNSNLDKHGIDFNEAQSLWGDPDLIEIQAKSEDEPRSLVIGRIGEKHWSAVITCRKESIRIISVRRSRKT
EVALYES

Nucleotide

• Length: 264 bp

>T242713 NZ_OW849527:c4783632-4783273 [Citrobacter freundii]
ATGACGAAACCACTTTACTGGGTTGGGCAGGCCAGAAAAGACCTGATTGCAATGCCAGAACACGTTCGGGATACGTTTGG
GTTTGCTCTTTGGCTTGCGCAACAGGGTAAACAGCATTCACAGACTAAACCATTAAAAGGATTTGGTGGAGCGGGGGTTC
TGGAAGTCGTTGAGGATTATCACGGCAACGCCTGGCGGGCGGTTTACACCATCCAGTTGAAAAATGCGGTTTATGTTCTC
CATGTTTTTCAGAAGAAGTCCGTTTCCGGGAAAGCAACCCCGAAACCTGAAATTGACCTGATTTATCAGCGGCTCAAGGC
TGCACAGCGCCATGCGCAGGAGAGTGGATATGTCACATGA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9698.01 Da
• Isoelectric Point: 8.6572

>AT242713 WP_250654859.1 NZ_CP096018:c1201370-1201119 [Alkalimarinus coralli]
MKAKDFDKKFDNNEDIIDDLDLSSIKRPNQAQKRVNVDFPTWMIDSLDKEANRVGVTRQSIIKVWLAEKLEEQAANKALH
RTR

Nucleotide

• Length: 252 bp

>AT242713 NZ_OW849527:c4783283-4782966 [Citrobacter freundii]
ATGTCACATGATGTCGAAACCAGTAGCGGTAATGTTTACGCCGATTTAGGTGCGTATGACGCAGAACAGATGCAGTTGAA
AGCGCAGCTGGCAATGGTGATTGGTGAGATTTTGCAACGCAAAGGGTTAACGCAGCAGCAGGCCGCGCAGTTACTGGGAA
TGACACAGCCTAAACTTTCCAATCTGCTACGCGGCCAGTTTCGCGGTATCAGTGAAGCAAAGATGCTCGAATGCCTGGTG
AGGCTGGGCCGTGATGTAGAGATTGTTGTCGGGAAAGAGGGCAATATGTCAGGAAAGCTGAAAGTGAAATTTGGCTGA