Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 176886..177448 Replicon chromosome
Accession NZ_CP096018
Organism Alkalimarinus coralli strain SCSIO 12817

Toxin (Protein)


Gene name ccdB Uniprot ID -
Locus tag MY525_RS00800 Protein ID WP_250658083.1
Coordinates 176886..177203 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID -
Locus tag MY525_RS00805 Protein ID WP_250658084.1
Coordinates 177203..177448 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MY525_RS00770 172094..172588 + 495 WP_250658081.1 GIY-YIG nuclease family protein -
MY525_RS00775 172589..174163 - 1575 WP_250655122.1 IS66 family transposase -
MY525_RS00780 174188..174547 - 360 WP_250655121.1 IS66 family insertion sequence element accessory protein TnpB -
MY525_RS00785 174544..174858 - 315 WP_250655120.1 hypothetical protein -
MY525_RS00790 175337..175543 - 207 Protein_154 group II intron reverse transcriptase/maturase -
MY525_RS00795 175775..176761 - 987 WP_250658082.1 transposase -
MY525_RS00800 176886..177203 - 318 WP_250658083.1 CcdB family protein Toxin
MY525_RS00805 177203..177448 - 246 WP_250658084.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
MY525_RS00810 178301..178531 + 231 WP_250658085.1 hypothetical protein -
MY525_RS00815 178531..178923 + 393 WP_250658086.1 type II toxin-antitoxin system VapC family toxin -
MY525_RS00820 179213..179761 + 549 WP_250658087.1 hypothetical protein -
MY525_RS00830 181126..181545 + 420 WP_250658089.1 hypothetical protein -
MY525_RS00835 181885..182367 + 483 WP_250658090.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 174188..174547 359


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(3-104)

Antitoxin

Post-segregation antitoxin CcdA

(11-81)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 11871.72 Da        Isoelectric Point: 6.9744

>T242709 WP_250658083.1 NZ_CP096018:c177203-176886 [Alkalimarinus coralli]
MTQFTLYKNEDRSSRKTYPYFVNVQSDLLKDLNSRLVIPLSPGSAVNNTNAKKLCPIINLDEGSFILLAHQMTSVPRSIL
KAEVTSLESYRYEIMDAIDMLITGI

Download         Length: 318 bp

>T242709 NZ_OW849527:2155921-2156024 [Citrobacter freundii]
GGCAGGGTAACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9149.26 Da        Isoelectric Point: 4.7558

>AT242709 WP_250658084.1 NZ_CP096018:c177448-177203 [Alkalimarinus coralli]
MQQAFNENAPKKATNLSINSDLLNKARGLKINLSATLEQALTIQVRNAERELWVEENKEAIQALNELADKNGLFSDSFRD
F

Download         Length: 246 bp

>AT242709 NZ_OW849527:c2156029-2155886 [Citrobacter freundii]
CACATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTT
GGCATTAATGCAGGCTAAGTTACCCTGCCATTTAAGAATAGATGACAGCGCCAGGTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References