Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-MazE
Location 2924892..2925493 Replicon chromosome
Accession NZ_CP096017
Organism Alkalimarinus coralli strain SCSIO 12638

Toxin (Protein)


Gene name chpB Uniprot ID -
Locus tag MY524_RS13335 Protein ID WP_250656371.1
Coordinates 2924892..2925242 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID -
Locus tag MY524_RS13340 Protein ID WP_250656372.1
Coordinates 2925236..2925493 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MY524_RS13300 2919892..2920914 - 1023 WP_250656364.1 amino acid ABC transporter substrate-binding protein -
MY524_RS13305 2921158..2921775 + 618 WP_250656365.1 GNAT family N-acetyltransferase -
MY524_RS13310 2921768..2922451 + 684 WP_250656366.1 DTW domain-containing protein -
MY524_RS13315 2922438..2923394 + 957 WP_250656367.1 NADP-dependent oxidoreductase -
MY524_RS13320 2923436..2923846 + 411 WP_250656368.1 CBS domain-containing protein -
MY524_RS13325 2924036..2924509 + 474 WP_250656369.1 YbaK/EbsC family protein -
MY524_RS13330 2924567..2924890 + 324 WP_250656370.1 hypothetical protein -
MY524_RS13335 2924892..2925242 - 351 WP_250656371.1 type II toxin-antitoxin system ChpB family toxin Toxin
MY524_RS13340 2925236..2925493 - 258 WP_250656372.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
MY524_RS13345 2925909..2926583 - 675 WP_250656373.1 hypothetical protein -
MY524_RS13350 2926738..2928570 - 1833 WP_256470507.1 sodium:proton antiporter -
MY524_RS13355 2928682..2929461 - 780 WP_250656375.1 tRNA cyclic N6-threonylcarbamoyladenosine(37) synthase TcdA -
MY524_RS13360 2929696..2930274 + 579 WP_250656376.1 CoA pyrophosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(9-114)

Antitoxin

SpoVT-AbrB domain

(6-50)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12531.71 Da        Isoelectric Point: 10.1838

>T242707 WP_250656371.1 NZ_CP096017:c2925242-2924892 [Alkalimarinus coralli]
MVRRKQFDRGDIVKVSLNPVVGREMQGNFRPCMVLSPAAFNRLGTALVAPITQGGDFARVKGFAVPLIGSGTETQGVMLV
NAVRMLDLEGRQAKKVEVAPQEIVDDVLARLAAIIE

Download         Length: 351 bp

>T242707 NZ_OW849527:c366591-366274 [Citrobacter freundii]
ATGTTCACATTTATTGAGCTACAAGGATTTAGTAAACGCCGTCCGTTACTTTTGCCTGACGATGAGTTTCGCGCTTTTCA
AGAGGCGCTTATAGAGAACCCTGAGGCTGGAGATACTATCGCTGGTACAGGTGGATTCAGAAAAATTCGCTGGAGTCGCT
CTGGTATGGGCAAACGCAGCGGTATTAGGGTTATCTATTACAACGTGACGCGCAAAGGTCGAATCTATCTCGCTTTGCTC
TATCCTAAAAATGAACAGGATGATTTAACCGAAGAGCAAAAAAGAGTTTTAATGCACTTATCCAATATGCTGATTTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9579.04 Da        Isoelectric Point: 4.8779

>AT242707 WP_250656372.1 NZ_CP096017:c2925493-2925236 [Alkalimarinus coralli]
MRTTIRKIGNSAGAILPATVLKKLNLSEGDVIEVSEDGKRIVIEPRNEKPKYSLTELMAQCDEKAPLPKELEEWNDMQPT
GKEVW

Download         Length: 258 bp

>AT242707 NZ_OW849527:c366221-365925 [Citrobacter freundii]
ATGAAAGACGAATTATTTGCCGATTTGCTGGCCAGTGCAGAAGAAATGGTGCGTATAGAGAAAGGTGAAGAAACACCTAA
GCCTGAACATGTACATACCTTTAGCGAAATTGATGTTAAAGCCATCCGCGAAGCAACAGGGTTACGCCAACAGGATTTTG
CCATAGCTGTTGGCGTGAGTTATGACCTGGTTAAAAGCTGGGAAACGAAACGACGCCAGCCGACTGGTGCACCAAGAAAA
CTGCTTTTATTAATTCAAAAAAATCCATTTATAATTAATCAATTAAAAGCAATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References