Detailed information of TA system TA242703

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/ParE-RHH
• Location: 1579016..1579578
• Replicon: chromosome
• Accession: NZ_CP096017
• Organism: Alkalimarinus coralli strain SCSIO 12638

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: MY524_RS07160
• Protein ID: WP_250655205.1
• Coordinates: 1579264..1579578 (+)
• Length: 105 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: -
• Locus tag: MY524_RS07155
• Protein ID: WP_250655204.1
• Coordinates: 1579016..1579264 (+)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MY524_RS07125	1576604..1576819	-	216	WP_045857757.1	helix-turn-helix domain-containing protein	-
MY524_RS07130	1577079..1577327	-	249	WP_250655199.1	helix-turn-helix domain-containing protein	-
MY524_RS07135	1577408..1577710	+	303	WP_250655200.1	type II toxin-antitoxin system HigB family toxin	-
MY524_RS07140	1577803..1578171	+	369	WP_250655201.1	transcriptional regulator	-
MY524_RS07145	1578164..1578496	+	333	WP_250655202.1	hypothetical protein	-
MY524_RS07150	1578556..1578870	+	315	WP_250655203.1	hypothetical protein	-
MY524_RS07155	1579016..1579264	+	249	WP_250655204.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
MY524_RS07160	1579264..1579578	+	315	WP_250655205.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
MY524_RS07165	1579775..1579957	-	183	WP_250655206.1	hypothetical protein	-
MY524_RS07170	1579957..1580232	-	276	WP_250655207.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
MY524_RS07175	1580433..1580897	-	465	WP_250655208.1	M15 family metallopeptidase	-
MY524_RS07180	1581289..1581996	+	708	WP_250655209.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (9-96)

Antitoxin

• Antitoxin ParD (1-79)

Sequences

Toxin

Protein

• Length: 105 a.a.
• Molecular weight: 12339.05 Da
• Isoelectric Point: 9.6406

>T242703 WP_250655205.1 NZ_CP096017:1579264-1579578 [Alkalimarinus coralli]
VKQKINSKVRVTPRARDDLKNIGRYTEQTWGKTQRNRYLKSIDARFHWLAENPQLGKHRTDICEEYYSFPEGQHVVFYLI
GRNSIDIIGIPHKEMDIISYFLEG

Nucleotide

• Length: 315 bp

>T242703 NZ_OW849471:165097-165588 [Klebsiella oxytoca]
GTGGGCAAAGTAACGGCTCCGGTCCCACTCGGTACGTCACACATCCTCGCTGAGTTTCACTGTGGTGAGCCTGTACTGGA
CGAATGGATAAAGCACCGGGGACTAAAAAATCAGTCCCTGGGGGCGGCCAGAACGTTTGTGGTGTGCCGGGGAAATGCTT
CACAGGTGCTTGCCTACTACTCTCTCGCGACCGGCAGCGTCACTCATGCCATTGCGCCGGGAAGCCTGCGAAGGAATATG
CCCGATCCTGTACCTGTCATCATCCTGGCCCGTCTTGCTGTCGATACGAGTTATCACGGCCAGGGACTGGGGGCTGATTT
ACTGCATGATGCCGTATTACGTTGCTGTCGGGTGGCTGAGAACATTGGCGTGCGGGCCGTTATGGTTCATGCACTCTCTG
ACAGTGCCAGACAGTTCTACATACATCACGGATTTATCCCTTCACAAACGCAGGATAGAACCCTTTTTTTACGGTTGCCT
CTCATTACTTAG

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 9007.90 Da
• Isoelectric Point: 4.3431

>AT242703 WP_250655204.1 NZ_CP096017:1579016-1579264 [Alkalimarinus coralli]
MATTSLSLGEHWEVFIKNEISSGRYGSASEVVRDALRAMEERKSKLEALRSHLAEGATQASNGDFVDNFSMDSLINDLDA
ET

Nucleotide

• Length: 249 bp

>AT242703 NZ_OW849471:164843-165109 [Klebsiella oxytoca]
ATGAAATCTGATGTTCAGCTCAACATCCGGGCGAAAGAAGCCCAGCGGGCTCTGATTGATACTGCCGCTGAGATTCTCCA
CAAATCACGCACTGATTTTATACTGGAGATGGCCTGTCAGGCGGCGGAAAACGTCATTCTTGACCGCCGTATGTTCAATC
TCAATGATGAACAGTACGCCGAGTTTATCGACATGCTGGATGCGCCGGTCACCGCTAACCCGGCGATGGAGAAACTCCTG
GCGAGAAAACCGCAGTGGGCAAAGTAA