Detailed information of TA system TA242701

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/Phd(antitoxin)
• Location: 1200181..1200737
• Replicon: chromosome
• Accession: NZ_CP096017
• Organism: Alkalimarinus coralli strain SCSIO 12638

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: MY524_RS05295
• Protein ID: WP_250654857.1
• Coordinates: 1200181..1200492 (-)
• Length: 104 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: MY524_RS05300
• Protein ID: WP_250654858.1
• Coordinates: 1200480..1200737 (-)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MY524_RS05275	1195921..1196940	+	1020	WP_250654853.1	PhoH family protein	-
MY524_RS05280	1196937..1197419	+	483	WP_250654854.1	rRNA maturation RNase YbeY	-
MY524_RS05285	1197416..1198258	+	843	WP_250654855.1	transporter associated domain-containing protein	-
MY524_RS05290	1198357..1199985	+	1629	WP_250654856.1	apolipoprotein N-acyltransferase	-
MY524_RS05295	1200181..1200492	-	312	WP_250654857.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
MY524_RS05300	1200480..1200737	-	258	WP_250654858.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
MY524_RS05305	1200819..1201070	-	252	WP_250654859.1	CopG family transcriptional regulator	-
MY524_RS05310	1201060..1201323	-	264	WP_250654860.1	BrnT family toxin	-
MY524_RS05315	1201869..1202105	+	237	WP_250654861.1	addiction module protein	-
MY524_RS05320	1202110..1202421	+	312	WP_250654862.1	type II toxin-antitoxin system RelE/ParE family toxin	-
MY524_RS05325	1202682..1202984	-	303	WP_250654863.1	hypothetical protein	-
MY524_RS05330	1202981..1203259	-	279	WP_250654864.1	BrnT family toxin	-
MY524_RS05335	1203850..1204320	-	471	WP_250654865.1	GNAT family N-acetyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integron	-	-	1198357..1202984	4627

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-91)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-70)

Sequences

Toxin

Protein

• Length: 104 a.a.
• Molecular weight: 11937.56 Da
• Isoelectric Point: 4.5858

>T242701 WP_250654857.1 NZ_CP096017:c1200492-1200181 [Alkalimarinus coralli]
MAQIIWTEPALNDLNDIAEYIAVSNPYAAKQLVENVFSNVQRLEQFPDSGRVPDEISNLNYREVVVNPCRVFYKIDMDSV
YILHVMRQERDLRKFLLSTTNGS

Nucleotide

• Length: 312 bp

>T242701 NZ_OW849470:c4607733-4607476 [Klebsiella oxytoca]
ATGAATCTATCCCGTCAGGAACAACGTACCTTACACGTTCTCGCTAAAGGTGGCCGGATCGCGCATATTCGCGATGCATC
AGGCCGCGTAATCTCTGTTGAATGCTACAGCCGCGAAGGGCTCCTGCTCAGCGACTGCACGCTCGCCGTTTTCAAAAAAC
TCAAAACCAAAAAACTCATTAAGTCCGTCAACGGGCAGCCCTACCGTATCAATACCACCGGGCTGAACAACGTTCGCGCT
CAGCTGGACAACCGCTAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9713.35 Da
• Isoelectric Point: 8.5371

>AT242701 WP_250654858.1 NZ_CP096017:c1200737-1200480 [Alkalimarinus coralli]
MRTEVVTTLKRQATKLLADLHESKEPILITEHGQPSAYLLDVADYELMVNRMKILEGIAKGEQAIRDGRTMDMGQAKDKM
NKWLK

Nucleotide

• Length: 258 bp

>AT242701 NZ_OW849470:c4607465-4606914 [Klebsiella oxytoca]
ATGACAAACCATAACTTCACCTTTCACATCACCTCAGAGCGTGATGCTGATGATATTCGCGAAGTTGAAACCCGGGCCTT
CGGCTTTAGCAAAGAGGCCGATCTGGTTGCCGATTTGCTCAACGATGAAAGTGCTCACCCGAGCTTATCTCTGCTGGCCA
AACATAATGGAAAAGCAGTTGGGCATATTTTGTTCACCCTGGCGACGTTCAAAGGGGAGTCTGACTCTCCGATGATGCAT
ATCCTTGCCCCCCTGGCGGTGGTGCCGGAATACCAGGGCGTGGGCGTAGGCGGATTGCTTATCCAGCGCGGTATTGAGCA
TCTGAAAGCCGCAGGAAGCGAGGCGGTATTTGTTCTGGGACATGCCGCTTATTACCCGCGGCATGGCTTTGAACCCTGTG
CCGGAGATAAAGGCTATCCGGCGCCTTATCCCATTCCCGAGGAGCATAAAGCCTGCTGGATGCTGCAGCGGCTTTCGTCC
CGGCCGCTGGGGAGAATCGGTCAGATACAGTGCGCCCGGGCGTTAATGAAACCCGAGCACTGGCGCGAGTAA