Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-MazE
Location 4344058..4344659 Replicon chromosome
Accession NZ_CP096016
Organism Alkalimarinus coralli strain SCSIO 12582

Toxin (Protein)


Gene name chpB Uniprot ID -
Locus tag MY523_RS19625 Protein ID WP_250656371.1
Coordinates 4344058..4344408 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID -
Locus tag MY523_RS19630 Protein ID WP_250656372.1
Coordinates 4344402..4344659 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MY523_RS19590 4339058..4340080 - 1023 WP_250656364.1 amino acid ABC transporter substrate-binding protein -
MY523_RS19595 4340324..4340941 + 618 WP_250656365.1 GNAT family N-acetyltransferase -
MY523_RS19600 4340934..4341617 + 684 WP_250656366.1 DTW domain-containing protein -
MY523_RS19605 4341604..4342560 + 957 WP_250656367.1 NADP-dependent oxidoreductase -
MY523_RS19610 4342602..4343012 + 411 WP_250656368.1 CBS domain-containing protein -
MY523_RS19615 4343202..4343675 + 474 WP_250656369.1 YbaK/EbsC family protein -
MY523_RS19620 4343733..4344056 + 324 WP_250656370.1 hypothetical protein -
MY523_RS19625 4344058..4344408 - 351 WP_250656371.1 type II toxin-antitoxin system ChpB family toxin Toxin
MY523_RS19630 4344402..4344659 - 258 WP_250656372.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
MY523_RS19635 4345075..4345749 - 675 WP_250656373.1 hypothetical protein -
MY523_RS19640 4345904..4347736 - 1833 WP_256470507.1 sodium:proton antiporter -
MY523_RS19645 4347848..4348627 - 780 WP_250656375.1 tRNA cyclic N6-threonylcarbamoyladenosine(37) synthase TcdA -
MY523_RS19650 4348862..4349440 + 579 WP_250656376.1 CoA pyrophosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(9-114)

Antitoxin

SpoVT-AbrB domain

(6-50)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12531.71 Da        Isoelectric Point: 10.1838

>T242697 WP_250656371.1 NZ_CP096016:c4344408-4344058 [Alkalimarinus coralli]
MVRRKQFDRGDIVKVSLNPVVGREMQGNFRPCMVLSPAAFNRLGTALVAPITQGGDFARVKGFAVPLIGSGTETQGVMLV
NAVRMLDLEGRQAKKVEVAPQEIVDDVLARLAAIIE

Download         Length: 351 bp

>T242697 NZ_OW849470:670096-670470 [Klebsiella oxytoca]
ATGAAATGGGTGAGCGCAAGCGAAGTCATTGCCTTTCATGATCGCATTTTACAACATCTCCCCGGCGTTAAAGGTATGTC
CGATCCTGGTCGGGCGGAAGCCATAATTTATCGTGTACAGAACCGCTTTCACTGTGAAGGGGTGAACGACATTTTTGAAC
TGGCTGCAACCTATTGGGTCGCTATCGCGCGTGGGCACATTTTTAATGATGGTAATAAGAGGACTGCTTTTTTTATCACC
ATGACGTTCCTGGCCCGCAATGGGTATCTTATCGCTGATGAAGATACCCGGTTGGAAGAACTCACTGTGCTGGCTGCGAC
AGGCGAAGCTACGGTAGTAGTTCTTGCTGATGCGTTACGGCAATTGGCGCTCTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9579.04 Da        Isoelectric Point: 4.8779

>AT242697 WP_250656372.1 NZ_CP096016:c4344659-4344402 [Alkalimarinus coralli]
MRTTIRKIGNSAGAILPATVLKKLNLSEGDVIEVSEDGKRIVIEPRNEKPKYSLTELMAQCDEKAPLPKELEEWNDMQPT
GKEVW

Download         Length: 258 bp

>AT242697 NZ_OW849470:669878-670099 [Klebsiella oxytoca]
ATGCGCTCTTATAGTACATCTGAAGCCAGACAGAATATTGCGGCCGTCATGGACGCCGCTGCCAGCGGAGAACCGATTGA
AATTACGCGGCGTGATGGAACGTCTAATGTTTTGATCAGTAAGGCTGAATATGAAACGTTTATGAATGCCAAACTTGATG
CGGAGTTTGATTTTATTATGCAGCGACACGGCCGCACAGTTAAGGCGTTGACCGATCGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References