Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/Phd(antitoxin)
Location 2614994..2615550 Replicon chromosome
Accession NZ_CP096016
Organism Alkalimarinus coralli strain SCSIO 12582

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag MY523_RS11565 Protein ID WP_250654857.1
Coordinates 2614994..2615305 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag MY523_RS11570 Protein ID WP_250654858.1
Coordinates 2615293..2615550 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MY523_RS11545 2610734..2611753 + 1020 WP_250654853.1 PhoH family protein -
MY523_RS11550 2611750..2612232 + 483 WP_250654854.1 rRNA maturation RNase YbeY -
MY523_RS11555 2612229..2613071 + 843 WP_250654855.1 transporter associated domain-containing protein -
MY523_RS11560 2613170..2614798 + 1629 WP_250654856.1 apolipoprotein N-acyltransferase -
MY523_RS11565 2614994..2615305 - 312 WP_250654857.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MY523_RS11570 2615293..2615550 - 258 WP_250654858.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
MY523_RS11575 2615632..2615883 - 252 WP_250654859.1 CopG family transcriptional regulator -
MY523_RS11580 2615873..2616136 - 264 WP_250654860.1 BrnT family toxin -
MY523_RS11585 2616682..2616918 + 237 WP_250654861.1 addiction module protein -
MY523_RS11590 2616923..2617234 + 312 WP_250654862.1 type II toxin-antitoxin system RelE/ParE family toxin -
MY523_RS11595 2617495..2617797 - 303 WP_250654863.1 hypothetical protein -
MY523_RS11600 2617794..2618072 - 279 WP_250654864.1 BrnT family toxin -
MY523_RS11605 2618663..2619133 - 471 WP_250654865.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integron - - 2613170..2617797 4627


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-70)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 11937.56 Da        Isoelectric Point: 4.5858

>T242691 WP_250654857.1 NZ_CP096016:c2615305-2614994 [Alkalimarinus coralli]
MAQIIWTEPALNDLNDIAEYIAVSNPYAAKQLVENVFSNVQRLEQFPDSGRVPDEISNLNYREVVVNPCRVFYKIDMDSV
YILHVMRQERDLRKFLLSTTNGS

Download         Length: 312 bp

>T242691 NZ_OW849377:c4191302-4190952 [Escherichia coli]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTG
AATCAGGTGCGGATGATGGATCTACGCGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGATGAGGTGGTGGAAGAGGC
GTTATTACGCTTGCAGGCGGTGGTGGAATAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9713.35 Da        Isoelectric Point: 8.5371

>AT242691 WP_250654858.1 NZ_CP096016:c2615550-2615293 [Alkalimarinus coralli]
MRTEVVTTLKRQATKLLADLHESKEPILITEHGQPSAYLLDVADYELMVNRMKILEGIAKGEQAIRDGRTMDMGQAKDKM
NKWLK

Download         Length: 258 bp

>AT242691 NZ_OW849377:c4191547-4191296 [Escherichia coli]
ATGCGTATTACCATAAAAAGATGGGGGAACAGTGCAGGTATGGTCATTCCCAATATCTTAATGAAAGAACTTAACTTACA
GCCGGGGCAGAGCGTGGAAGCGCAGGTGAGCAACAACCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCGCGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References