Detailed information of TA system TA242688

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): ccdAB/CcdA(antitoxin)
• Location: 1593250..1593812
• Replicon: chromosome
• Accession: NZ_CP096016
• Organism: Alkalimarinus coralli strain SCSIO 12582

Toxin (Protein)

• Gene name: ccdB
• Uniprot ID: -
• Locus tag: MY523_RS07060
• Protein ID: WP_250658083.1
• Coordinates: 1593250..1593567 (-)
• Length: 106 a.a.

Antitoxin (Protein)

• Gene name: ccdA
• Uniprot ID: -
• Locus tag: MY523_RS07065
• Protein ID: WP_250658084.1
• Coordinates: 1593567..1593812 (-)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MY523_RS07030	1588458..1588952	+	495	WP_250658081.1	GIY-YIG nuclease family protein	-
MY523_RS07035	1588953..1590527	-	1575	WP_250655122.1	IS66 family transposase	-
MY523_RS07040	1590552..1590911	-	360	WP_250655121.1	IS66 family insertion sequence element accessory protein TnpB	-
MY523_RS07045	1590908..1591222	-	315	WP_250655120.1	hypothetical protein	-
MY523_RS07050	1591701..1591907	-	207	Protein_1392	group II intron reverse transcriptase/maturase	-
MY523_RS07055	1592139..1593125	-	987	WP_250658082.1	transposase	-
MY523_RS07060	1593250..1593567	-	318	WP_250658083.1	CcdB family protein	Toxin
MY523_RS07065	1593567..1593812	-	246	WP_250658084.1	type II toxin-antitoxin system CcdA family antitoxin	Antitoxin
MY523_RS07070	1594665..1594895	+	231	WP_250658085.1	hypothetical protein	-
MY523_RS07075	1594895..1595287	+	393	WP_250658086.1	type II toxin-antitoxin system VapC family toxin	-
MY523_RS07080	1595577..1596125	+	549	WP_250658087.1	hypothetical protein	-
MY523_RS07090	1597490..1597909	+	420	WP_250658089.1	hypothetical protein	-
MY523_RS07095	1598249..1598731	+	483	WP_250658090.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1587902..1596125	8223
	-	flank	IS/Tn	-	-	1590552..1590911	359

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin CcdB (3-104)

Antitoxin

• Post-segregation antitoxin CcdA (11-81)

Sequences

Toxin

Protein

• Length: 106 a.a.
• Molecular weight: 11871.72 Da
• Isoelectric Point: 6.9744

>T242688 WP_250658083.1 NZ_CP096016:c1593567-1593250 [Alkalimarinus coralli]
MTQFTLYKNEDRSSRKTYPYFVNVQSDLLKDLNSRLVIPLSPGSAVNNTNAKKLCPIINLDEGSFILLAHQMTSVPRSIL
KAEVTSLESYRYEIMDAIDMLITGI

Nucleotide

• Length: 318 bp

>T242688 NZ_OW849377:3550834-3551376 [Escherichia coli]
ATGGTCGACAAGCATGAAGAGATTACTCTGCCCATAGTCCTCTCCTGTAATTATCAGTCTGATATTACTTATCCTGGGCA
AAAACAGTTTGATTGCGGTAACCCTGTTATCGATAAATTTGTACGCGCATCGCTAAAGAAAAGTGTGCGTAATAGCGACT
GTGCGGCTAAAGCACTTATTGACAGACAAAGTGGTGAACTGATCGGCATCTGTACTTTTACGGCATATTCGCTGGAAAAA
CAACGCGTTTCTGGCGTCCTTCAGGGTTCACAACCTTCAGAAATTGGTGTTGTCAGATTAGTCATGTTGGGGGTAGCACG
GAAGTATCAAAAGCGGGGCTTTGGTCAGGACCTACTATGTGATTTTTTTGAACATGTAAAAATAATTCACCAGGCATTAC
CAATTAAAGGGGTTTATCTTGATGCTGACCCTGCCGCCATTAATTTTTATGCTCGTCTCGGCTTTGTTCAGCTTTCAGCG
ACACCAAATGCTTTTGGTGCTGTACCTATGTTTTTGGCGATTCAGCATATTCTCGCGGCTTAG

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 9149.26 Da
• Isoelectric Point: 4.7558

>AT242688 WP_250658084.1 NZ_CP096016:c1593812-1593567 [Alkalimarinus coralli]
MQQAFNENAPKKATNLSINSDLLNKARGLKINLSATLEQALTIQVRNAERELWVEENKEAIQALNELADKNGLFSDSFRD
F

Nucleotide

• Length: 246 bp

>AT242688 NZ_OW849377:3550539-3550850 [Escherichia coli]
ATGCCTGGAAAAACAGCCACTCTACCCGATGTCGATAAAACGCTGAAAAATGCGCGGGTCGAACTCAAAACTAGTCCCGA
TGCCAAAAACAAACTTCGTGAAGCTGCGCAAGCCGTTGGGGTAGATTTAAGCGCTTTTATTTTGAGCGCTGCTATGGAAC
GCGCCGAAAGTGTGCTTGATAACCAACGTCGCCGTGAGCTTTCGAATCAAAGCTGGGAACTGATGAACCAACTCATCGCT
GAACCTGCTCAACCGACGCTCGCCCTCAAGGCGTTAATGAAAAGGAAAAACAGCGATGGTCGACAAGCATGA