Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tad-ata/COG5606-COG4679
Location 183447..184140 Replicon plasmid unnamed
Accession NZ_CP095924
Organism Pseudomonas aeruginosa strain AR19438

Toxin (Protein)


Gene name tad Uniprot ID N2IHR9
Locus tag MX621_RS31935 Protein ID WP_003151133.1
Coordinates 183447..183824 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name ata Uniprot ID N2IIN5
Locus tag MX621_RS31940 Protein ID WP_001172026.1
Coordinates 183805..184140 (+) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MX621_RS31925 (MX621_31925) 179640..182669 - 3030 WP_010799689.1 Tn3 family transposase -
MX621_RS31930 (MX621_31930) 182653..183255 - 603 WP_010465829.1 recombinase family protein -
MX621_RS31935 (MX621_31935) 183447..183824 + 378 WP_003151133.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MX621_RS31940 (MX621_31940) 183805..184140 + 336 WP_001172026.1 helix-turn-helix transcriptional regulator Antitoxin
MX621_RS31945 (MX621_31945) 184155..184490 + 336 WP_000741275.1 hypothetical protein -
MX621_RS31950 (MX621_31950) 184514..184840 + 327 WP_000091614.1 hypothetical protein -
MX621_RS31955 (MX621_31955) 184856..185197 + 342 WP_025999701.1 hypothetical protein -
MX621_RS31960 (MX621_31960) 185359..185766 + 408 WP_023383755.1 hypothetical protein -
MX621_RS31965 (MX621_31965) 185763..186278 + 516 WP_023383756.1 hypothetical protein -
MX621_RS31970 (MX621_31970) 186337..186627 + 291 WP_023383757.1 hypothetical protein -
MX621_RS31975 (MX621_31975) 186787..187446 + 660 WP_023383758.1 hypothetical protein -
MX621_RS31980 (MX621_31980) 187542..188399 - 858 WP_004574800.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid qnrVC6 / qacE / sul1 / blaNDM-14 - 1..275369 275369


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(16-109)

Antitoxin

Cro/C1-type helix-turn-helix domain

(40-93)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 13705.78 Da        Isoelectric Point: 9.4693

>T242686 WP_003151133.1 NZ_CP095924:183447-183824 [Pseudomonas aeruginosa]
MTNKEKPLEWIASSHKDLMALPSDVRRRFGYALSLAQIGDQDDAAKVLKGFGGAGVLEVVEDDAGGTYRAVYTVKFAEAV
FVLHCFQKKSKSGIATPKADMDIIRARLKVAEVLAQELRNAKTNH

Download         Length: 378 bp

>T242686 NZ_OW849377:2679583-2679690 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGGATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12201.39 Da        Isoelectric Point: 10.6058

>AT242686 WP_001172026.1 NZ_CP095924:183805-184140 [Pseudomonas aeruginosa]
MQKRIIEGVEVQRSSGNVFADLGLPDAEKLKIKTGLVVEIRRAMRALGLTQQAAAKRMGIPQPKVSGMMRGDFTNLSERK
LMDCLNRLGYDIEIKVRPAAEPIGHLTLATA

Download         Length: 336 bp

>AT242686 NZ_OW849377:c2679527-2679471 [Escherichia coli]
TCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A024ELN5

Antitoxin

Source ID Structure
AlphaFold DB A0A024EKI7

References