Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/COG3657-dnstrm_HI1420
Location 5288539..5289125 Replicon chromosome
Accession NZ_CP095923
Organism Pseudomonas aeruginosa strain AR19438

Toxin (Protein)


Gene name PumA Uniprot ID G8CP73
Locus tag MX621_RS24900 Protein ID WP_003120987.1
Coordinates 5288826..5289125 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag MX621_RS24895 Protein ID WP_003448662.1
Coordinates 5288539..5288829 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MX621_RS24880 (MX621_24880) 5284123..5286012 + 1890 WP_023101908.1 hypothetical protein -
MX621_RS24885 (MX621_24885) 5286009..5287985 + 1977 WP_031691363.1 DEAD/DEAH box helicase -
MX621_RS24890 (MX621_24890) 5288124..5288468 + 345 WP_023082045.1 hypothetical protein -
MX621_RS24895 (MX621_24895) 5288539..5288829 - 291 WP_003448662.1 putative addiction module antidote protein Antitoxin
MX621_RS24900 (MX621_24900) 5288826..5289125 - 300 WP_003120987.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MX621_RS24905 (MX621_24905) 5289327..5290451 + 1125 WP_023082046.1 TcpQ domain-containing protein -
MX621_RS24910 (MX621_24910) 5290451..5292160 + 1710 WP_010792227.1 PilN family type IVB pilus formation outer membrane protein -
MX621_RS24915 (MX621_24915) 5292164..5293489 + 1326 WP_003120992.1 type 4b pilus protein PilO2 -
MX621_RS24920 (MX621_24920) 5293479..5294012 + 534 WP_003120993.1 type IV pilus biogenesis protein PilP -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 5258085..5344688 86603


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(3-96)

Antitoxin

Cro/C1-type helix-turn-helix domain

(47-90)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11133.88 Da        Isoelectric Point: 10.4495

>T242684 WP_003120987.1 NZ_CP095923:c5289125-5288826 [Pseudomonas aeruginosa]
MVEVKQTATFMAWESKLKDRRAKAVIAARIFRLANGLPGDVSPVGQGVSELRIHYGPGYRVYFQQRGTEIVILLCGGDKS
SQARDIEMAKRLANEWRPQ

Download         Length: 300 bp

>T242684 NZ_OW849377:2007684-2007787 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10394.91 Da        Isoelectric Point: 4.7527

>AT242684 WP_003448662.1 NZ_CP095923:c5288829-5288539 [Pseudomonas aeruginosa]
MTEQIYDYDPAQALDSPEAMALFIADALDTGDTAYIAKAMGVVARAKGMTELAKETGLAREQLYKSFSERGNPTLKTMLA
VMRALGVDLTARPHAQ

Download         Length: 291 bp

>AT242684 NZ_OW849377:c2007825-2007554 [Escherichia coli]
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGTAAAATGGTCAATAAAAAGCGCGGTGGTCATCAGCTTAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G8CP73

Antitoxin

Source ID Structure

References