Detailed information of TA system TA242678

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RHH(antitoxin)
• Location: 157305..157810
• Replicon: chromosome
• Accession: NZ_CP095923
• Organism: Pseudomonas aeruginosa strain AR19438

Toxin (Protein)

• Gene name: parE
• Uniprot ID: V6A7K8
• Locus tag: MX621_RS00710
• Protein ID: WP_003083773.1
• Coordinates: 157305..157586 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: A0A1C7BDS9
• Locus tag: MX621_RS00715
• Protein ID: WP_003083775.1
• Coordinates: 157583..157810 (-)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MX621_RS00685 (MX621_00685)	152556..153905	+	1350	WP_003137006.1	C4-dicarboxylate transporter DctA	-
MX621_RS00690 (MX621_00690)	153954..154640	+	687	WP_003083762.1	FadR/GntR family transcriptional regulator	-
MX621_RS00695 (MX621_00695)	154741..155475	+	735	WP_003110658.1	GntR family transcriptional regulator	-
MX621_RS00700 (MX621_00700)	155655..156065	+	411	WP_003110659.1	aegerolysin family protein	-
MX621_RS00705 (MX621_00705)	156097..157005	-	909	WP_003083769.1	LysR family transcriptional regulator	-
MX621_RS00710 (MX621_00710)	157305..157586	-	282	WP_003083773.1	type II toxin-antitoxin system toxin ParE	Toxin
MX621_RS00715 (MX621_00715)	157583..157810	-	228	WP_003083775.1	CopG family ribbon-helix-helix protein	Antitoxin
MX621_RS00720 (MX621_00720)	157986..158606	-	621	WP_003101226.1	hypothetical protein	-
MX621_RS00725 (MX621_00725)	158707..159207	+	501	WP_003101228.1	LEA type 2 family protein	-
MX621_RS00730 (MX621_00730)	159280..159621	+	342	WP_003101229.1	zinc ribbon domain-containing protein YjdM	-
MX621_RS00735 (MX621_00735)	159703..161130	-	1428	WP_003083784.1	GABA permease	-
MX621_RS00740 (MX621_00740)	161299..162792	-	1494	WP_003101230.1	CoA-acylating methylmalonate-semialdehyde dehydrogenase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-87)

Antitoxin

• Ribbon-helix-helix protein, CopG (5-42)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10462.19 Da
• Isoelectric Point: 10.0435

>T242678 WP_003083773.1 NZ_CP095923:c157586-157305 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Nucleotide

• Length: 282 bp

>T242678 NZ_OW849377:c781642-781265 [Escherichia coli]
ATGAACACATTACCCGACACACACGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTACGGCCTCACGCTGAATGACACACCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGCTGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCCGGGCAACAGGCCTGATGACCCGCGA
CAATTACAGAATGGTAAATAACATTACCCAGGGTAAGCATCCGGAGGCGCAACAATGA

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8556.58 Da
• Isoelectric Point: 5.5740

>AT242678 WP_003083775.1 NZ_CP095923:c157810-157583 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Nucleotide

• Length: 228 bp

>AT242678 NZ_OW849377:c782100-781732 [Escherichia coli]
GTGTCAGACACACTGCCCGGGACAACGCATCCCGACGACAATCACGACCGCCTCTGGTGGGGACTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGAAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGATGCAGATGCATACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGTGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAACGAAAACGTAA

Structures

Toxin

• PDB: 6XRW

Antitoxin

• AlphaFold DB: A0A1C7BDS9