242672

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) slvAT/RES(toxin)
Location 398955..399871 Replicon plasmid unnamed
Accession NZ_CP095921
Organism Pseudomonas aeruginosa strain AR19640

Toxin (Protein)


Gene name slvT Uniprot ID A0A2L1KI32
Locus tag MX651_RS31795 Protein ID WP_019437783.1
Coordinates 398955..399479 (-) Length 175 a.a.

Antitoxin (Protein)


Gene name slvA Uniprot ID A0A2L1KH13
Locus tag MX651_RS31800 Protein ID WP_019437782.1
Coordinates 399476..399871 (-) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MX651_RS31775 (MX651_31775) 394276..395421 + 1146 WP_021263240.1 glycerate kinase -
MX651_RS31780 (MX651_31780) 395841..396032 - 192 WP_019437785.1 hypothetical protein -
MX651_RS31785 (MX651_31785) 396407..397462 + 1056 WP_139139567.1 prepilin-type N-terminal cleavage/methylation domain-containing protein -
MX651_RS31790 (MX651_31790) 397659..398909 + 1251 WP_019437784.1 TerD family protein -
MX651_RS31795 (MX651_31795) 398955..399479 - 525 WP_019437783.1 RES family NAD+ phosphorylase Toxin
MX651_RS31800 (MX651_31800) 399476..399871 - 396 WP_019437782.1 hypothetical protein Antitoxin
MX651_RS31805 (MX651_31805) 400455..402338 - 1884 WP_223819158.1 helicase -
MX651_RS31810 (MX651_31810) 402538..402792 + 255 WP_021263738.1 hypothetical protein -
MX651_RS31815 (MX651_31815) 403686..404210 + 525 WP_010794447.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid mph(E) / sul1 / qacE / aadA1 / cmlA1 / ant(2'')-Ia / aac(6')-Il / blaNDM-14 / dfrA27 / ARR-3 / blaOXA-246 / aac(6')-IIa / qnrVC1 / dfrA22 - 1..495621 495621


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(10-167)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 175 a.a.        Molecular weight: 19052.57 Da        Isoelectric Point: 4.5535

>T242672 WP_019437783.1 NZ_CP095921:c399479-398955 [Pseudomonas aeruginosa]
MKIIGVQDLPCYRMHTPKWSVAPTSGAGAATQGGRVNRKGLEALYLSLESATAIAEFQQASAFLPPGLLISYSLSLDRVI
DFTGGYNDTWAPIWQDFFCDWRKIRFNDGVEPPSWIIGDLAIEADCAGILFESVANPGGRNLVLFTDQLPVHGNIVVNDP
RGDLPTDQSSWTRP

Download         Length: 525 bp

>T242672 NZ_OW849377:193258-193365 [Escherichia coli]
ATGACGCTCGCAGAACTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGTATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14753.87 Da        Isoelectric Point: 7.2048

>AT242672 WP_019437782.1 NZ_CP095921:c399871-399476 [Pseudomonas aeruginosa]
MASKAVLELRPTNFAGLMDALKEVNRVMFSPERFLKVFSMDQQTLALRAHVHRNTVRNAPESEKVQAYIRDSVKVLRAVT
DMGTDVTNAIFWFKNEPLSTFGYKTAEEVVSEGKTEQLIAFLQSWEAGAQG

Download         Length: 396 bp

>AT242672 NZ_OW849377:c193200-193146 [Escherichia coli]
CAAGAATGGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2L1KI32

Antitoxin

Source ID Structure
AlphaFold DB A0A2L1KH13

References