Detailed information of TA system TA242670

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /Xre(antitoxin)
• Location: 4394145..4395403
• Replicon: chromosome
• Accession: NZ_CP095920
• Organism: Pseudomonas aeruginosa strain AR19640

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: MX651_RS20195
• Protein ID: WP_003163133.1
• Coordinates: 4394145..4394900 (-)
• Length: 252 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: V6AJU7
• Locus tag: MX651_RS20200
• Protein ID: WP_003086329.1
• Coordinates: 4395035..4395403 (-)
• Length: 123 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MX651_RS20185 (MX651_20185)	4389317..4391860	+	2544	WP_003140632.1	acyl-homoserine-lactone acylase QuiP	-
MX651_RS20190 (MX651_20190)	4392015..4393376	-	1362	WP_079262974.1	DNA recombination protein RmuC	-
MX651_RS20195 (MX651_20195)	4394145..4394900	-	756	WP_003163133.1	RES family NAD+ phosphorylase	Toxin
MX651_RS20200 (MX651_20200)	4395035..4395403	-	369	WP_003086329.1	DUF2384 domain-containing protein	Antitoxin
MX651_RS20205 (MX651_20205)	4395476..4396762	-	1287	WP_003163134.1	FAD-binding oxidoreductase	-
MX651_RS20210 (MX651_20210)	4396818..4398311	-	1494	WP_003086325.1	aldehyde dehydrogenase family protein	-
MX651_RS20215 (MX651_20215)	4398486..4398962	+	477	WP_003112531.1	hypothetical protein	-
MX651_RS20220 (MX651_20220)	4398965..4399240	-	276	WP_169057979.1	zinc ribbon domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (63-207)

Antitoxin

• Cro/C1-type helix-turn-helix domain (23-47)

Sequences

Toxin

Protein

• Length: 252 a.a.
• Molecular weight: 28250.37 Da
• Isoelectric Point: 7.7294

>T242670 WP_003163133.1 NZ_CP095920:c4394900-4394145 [Pseudomonas aeruginosa]
VSEIWRQCKGERHIRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMAVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRAPQELGSAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA

Nucleotide

• Length: 756 bp

>T242670 NZ_OW849195:c3942705-3942295 [Enterobacter cloacae]
GTGGTCCTGTGGCAATCTGATCTTCGCGTCTCGTGGCGCTCGCAGTGGATGTCGTTAATGCTCCACGGCCTGGTTGCGGC
CATCGTGTTACTCATGCCATGGCCCCTGAGCTATACACCGCTGTGGCTGCTATTACTTTCGTTTGTCGTTTTTGACAGCG
TACGCAGCCAGCGTCGCATTAATGCTCGTCAGGGTGAGATCAAGTTACTGATGGATTCCCGCCTGCGCTGGCAGGGAAAA
GAGTGGGATATTCTGGGTATGCCATGGATGCTCAACTCCGGCATGATGTTACGGTTACGCAATGTGGACGGCGGGCGTTG
CCAGCACCTGTGGCTGGCGGCTGACAGTATGGATGCTTCAGAATGGCGAGATCTGCGCCGGATGTTGTTGCAACAGCCGA
CGCAGGAGTAA

Antitoxin

Protein

• Length: 123 a.a.
• Molecular weight: 13367.63 Da
• Isoelectric Point: 9.9874

>AT242670 WP_003086329.1 NZ_CP095920:c4395403-4395035 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Nucleotide

• Length: 369 bp

>AT242670 NZ_OW849195:c3942952-3942686 [Enterobacter cloacae]
ATGGATATTAACAACAAGGCCCGTATTCACTGGGCATGCCGTCGCGGCATGCGTGAACTTGATATTTCCATCATGCCTTT
CTTCGAATATGAGTATGACAGCTTAAGCGATGATGATAAGCGGCTGTTTGTTCGCCTGCTTGAGTCTGACGATCCAGATT
TATTCAACTGGCTGATGAACCACGGCAAACCCGCCGACACCGAGTTGCAACGGATGGTGCAATTAATTCAAACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Structures

Antitoxin

• AlphaFold DB: V6AJU7