Detailed information of TA system TA242669

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/-
• Location: 3472558..3473779
• Replicon: chromosome
• Accession: NZ_CP095920
• Organism: Pseudomonas aeruginosa strain AR19640

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: A0A0C7CS07
• Locus tag: MX651_RS15875
• Protein ID: WP_003102740.1
• Coordinates: 3473201..3473779 (+)
• Length: 193 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: MX651_RS15870
• Protein ID: WP_003088112.1
• Coordinates: 3472558..3473112 (+)
• Length: 185 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MX651_RS15845 (MX651_15845)	3468126..3468677	+	552	WP_003132721.1	XRE family transcriptional regulator	-
MX651_RS15850 (MX651_15850)	3468674..3469072	-	399	WP_003088123.1	NADH-quinone oxidoreductase subunit A	-
MX651_RS15855 (MX651_15855)	3469085..3469408	-	324	WP_003102734.1	multidrug efflux SMR transporter	-
MX651_RS15860 (MX651_15860)	3469739..3470200	+	462	WP_003102736.1	(2Fe-2S)-binding protein	-
MX651_RS15865 (MX651_15865)	3470205..3472400	+	2196	WP_014603034.1	xanthine dehydrogenase family protein molybdopterin-binding subunit	-
MX651_RS15870 (MX651_15870)	3472558..3473112	+	555	WP_003088112.1	helix-turn-helix transcriptional regulator	Antitoxin
MX651_RS15875 (MX651_15875)	3473201..3473779	+	579	WP_003102740.1	HD domain-containing protein	Toxin
MX651_RS15880 (MX651_15880)	3473887..3475074	-	1188	WP_003102741.1	HlyD family efflux transporter periplasmic adaptor subunit	-
MX651_RS15885 (MX651_15885)	3475064..3477235	-	2172	WP_014603035.1	type I secretion system permease/ATPase	-
MX651_RS15890 (MX651_15890)	3477225..3478502	-	1278	WP_003102743.1	TolC family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HD domain (16-170)

Antitoxin

• Cro/C1-type helix-turn-helix domain (14-62)

Sequences

Toxin

Protein

• Length: 193 a.a.
• Molecular weight: 21869.70 Da
• Isoelectric Point: 5.3655

>T242669 WP_003102740.1 NZ_CP095920:3473201-3473779 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAARRDA

Nucleotide

• Length: 579 bp

>T242669 NZ_OW849195:c2916605-2916502 [Enterobacter cloacae]
GGCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin

Protein

• Length: 185 a.a.
• Molecular weight: 20454.63 Da
• Isoelectric Point: 8.1590

>AT242669 WP_003088112.1 NZ_CP095920:3472558-3473112 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Nucleotide

• Length: 555 bp

>AT242669 NZ_OW849195:2916486-2916640 [Enterobacter cloacae]
TGTCTTTCATACAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTG
CGCTAAAAGTTGGCATTAATGCAGGCTAAGTCGCCTTGCCTTTTAAGAATAGATGACGACGCCAGGTTTTCCAGT

Structures

Toxin

• AlphaFold DB: A0A0C7CS07