Detailed information of TA system TA242668

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /Acetyltransf_4(toxin)
• Location: 1824179..1825687
• Replicon: chromosome
• Accession: NZ_CP095920
• Organism: Pseudomonas aeruginosa strain AR19640

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: MX651_RS08495
• Protein ID: WP_012613851.1
• Coordinates: 1824179..1824766 (+)
• Length: 196 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: Q9HYX2
• Locus tag: MX651_RS08500
• Protein ID: WP_003115566.1
• Coordinates: 1824833..1825687 (+)
• Length: 285 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MX651_RS08490 (MX651_08490)	1820434..1823913	-	3480	WP_003117605.1	PAS domain-containing hybrid sensor histidine kinase/response regulator	-
MX651_RS08495 (MX651_08495)	1824179..1824766	+	588	WP_012613851.1	GNAT family protein	Toxin
MX651_RS08500 (MX651_08500)	1824833..1825687	+	855	WP_003115566.1	AraC family transcriptional regulator	Antitoxin
MX651_RS08505 (MX651_08505)	1825784..1827949	+	2166	WP_003115567.1	TonB-dependent receptor family protein	-
MX651_RS08510 (MX651_08510)	1828124..1829998	+	1875	WP_014602678.1	MFS transporter	-
MX651_RS08515 (MX651_08515)	1830059..1830268	-	210	WP_003115568.1	cold-shock protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (20-152)

Antitoxin

• AraC-type arabinose-binding/dimerisation domain (19-151)

Sequences

Toxin

Protein

• Length: 196 a.a.
• Molecular weight: 21929.29 Da
• Isoelectric Point: 9.8676

>T242668 WP_012613851.1 NZ_CP095920:1824179-1824766 [Pseudomonas aeruginosa]
MSRRAPMFKPLPITLQRGALRLEPLVEADIPELVSLAEANREALQYMDGPTRPDWYRQSLAEQREGRALPLAVRLGVQLV
GTTRFAEFLPALPACEIGWTWLDQAQHGSGLNRMIKYLMLKHAFDNLRMVRVQLSTAASNLRAQGAIDKLGAQREGVLRN
HRRLAGGRLDDTFVYSITDHEWPQVKAVLEASFTG

Nucleotide

• Length: 588 bp

>T242668 NZ_OW849195:1844018-1844542 [Enterobacter cloacae]
ATCGTGGCAAATCTCACGATCGAAATGTTTTCAGAGGGAAGTGATTACGATTTCAGGGGCTTCGATTGTGGTGAACCCTC
GCTCAATGCCTTCCTGACGGAACATCTGGTGCGTCAGCACAAGGGACGGATATTGCGAGGCTACCTGCTTAAAGATCGTG
ACCATCCGCGTGTGCTGGGCTATTACACGTTGTCCGGAAGTTGCTTTGAAAAAGCGATGCTTCCTTCTAAGACCCAGCAG
CGTCGGATCCCCTATGTCAACGTACCCAGTGTGACGCTGGGGCGTCTGGCTGTGCATAAAGATCTACAGGGAAAGGAGTG
GGGAACAACGCTCGTCGCACATGCTATGCGCGTTGTGTATCTGGCATCGCAGGCGGTAGGGGTACACGGAATCTTTGTTG
ATGCTCTCAATGAACAGGCAAAACGATTCTATCTGAAGCAGGGTTTTATTCCGCTGACAGGTGAAAACAGCCATTCTCTT
TTCTTCCCCACAAAATCTATCGAACAACTCTTTGAGCAGGCGTGA

Antitoxin

Protein

• Length: 285 a.a.
• Molecular weight: 31933.23 Da
• Isoelectric Point: 7.3276

>AT242668 WP_003115566.1 NZ_CP095920:1824833-1825687 [Pseudomonas aeruginosa]
VPDETSGEHTHFWRAAELGGVELLHARYVEQRFAPHVHSSFALVIIEQGAQRFRHRGGEHLAPLGSMVLINPDEVHTGSK
AHDAGWLYRGYYPEMEQIDGILDELEIHHGGVPRFADSVIHDQPLARAFVHLHRLLAEHADSLETQTRWRETVLALFRRH
ARLPEAPKAGQEPLAVARARELLAARLLDPPSLEELAAAVNLSPFHFARVFRRATGMPPHAWLRQRRLEQARALLKSGRA
PLEVALELGFADQSHLGRQFKQAYGVAPGEYRSACARSSLTIYE

Nucleotide

• Length: 855 bp

>AT242668 NZ_OW849195:1843745-1844014 [Enterobacter cloacae]
ATGCCAGCACTTAAAAAACAGCGTATCGATCTTCGCTTAACGGACGAAGACAAAACAATGATTGAAGAAGCGGCGGCGAT
GACGAACCAGACAATCACCCAGTTTATGGTGAACAGTGCGTCAGAACGCGCTGCTGAAGTCATCGAACAACATCGGCGTC
TCGTATTAAACGAGTCATCATGGAATGCGGTGATGGACGCCATCGACAATCCGCCAGAGCCAAATGAACGCCTGAAGCGA
GCGGCAAAACGTCTTCGAAACATGGAGTGA

Structures

Antitoxin

• AlphaFold DB: Q9HYX2