Detailed information of TA system TA242667

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RHH(antitoxin)
• Location: 141505..142010
• Replicon: chromosome
• Accession: NZ_CP095920
• Organism: Pseudomonas aeruginosa strain AR19640

Toxin (Protein)

• Gene name: parE
• Uniprot ID: V6A7K8
• Locus tag: MX651_RS00645
• Protein ID: WP_003083773.1
• Coordinates: 141505..141786 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: A0A1C7BDS9
• Locus tag: MX651_RS00650
• Protein ID: WP_003083775.1
• Coordinates: 141783..142010 (-)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MX651_RS00620 (MX651_00620)	136756..138105	+	1350	WP_003119513.1	C4-dicarboxylate transporter DctA	-
MX651_RS00625 (MX651_00625)	138154..138840	+	687	WP_003083762.1	FadR/GntR family transcriptional regulator	-
MX651_RS00630 (MX651_00630)	138941..139675	+	735	WP_003117208.1	GntR family transcriptional regulator	-
MX651_RS00635 (MX651_00635)	139855..140265	+	411	WP_003101225.1	aegerolysin family protein	-
MX651_RS00640 (MX651_00640)	140297..141205	-	909	WP_003083769.1	LysR family transcriptional regulator	-
MX651_RS00645 (MX651_00645)	141505..141786	-	282	WP_003083773.1	type II toxin-antitoxin system toxin ParE	Toxin
MX651_RS00650 (MX651_00650)	141783..142010	-	228	WP_003083775.1	CopG family ribbon-helix-helix protein	Antitoxin
MX651_RS00655 (MX651_00655)	142186..142806	-	621	WP_003101226.1	hypothetical protein	-
MX651_RS00660 (MX651_00660)	142907..143407	+	501	WP_003112629.1	LEA type 2 family protein	-
MX651_RS00665 (MX651_00665)	143480..143821	+	342	WP_003101229.1	zinc ribbon domain-containing protein YjdM	-
MX651_RS00670 (MX651_00670)	143903..145330	-	1428	WP_003083784.1	GABA permease	-
MX651_RS00675 (MX651_00675)	145499..146992	-	1494	WP_003101230.1	CoA-acylating methylmalonate-semialdehyde dehydrogenase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-87)

Antitoxin

• Ribbon-helix-helix protein, CopG (5-42)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10462.19 Da
• Isoelectric Point: 10.0435

>T242667 WP_003083773.1 NZ_CP095920:c141786-141505 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Nucleotide

• Length: 282 bp

>T242667 NZ_OW849195:c1250272-1249910 [Enterobacter cloacae]
ATGTGGAATGTCGAGACAACGGACAGATTTGATCAATGGTACTTCGAACAAACAACAGCATTAAAAGAAGATGTGCTAGC
GATGATGCATATTCTTGCTGAGTTTGGCCCAACGCTTGGGCGGCCATACGTAGATACCGTGAAGGCTTCAGCCTATGCGA
ACATGAAGGAATTACGGATTCAACATGCGGGAAATCCCATCAGAGCTTTTTTTGCTTTTGATCCTGACCGTAAGGCAATT
GTGCTCTGTGCTGGAGACAAAACCGGTTGCAATCAAAAACGGTTTTATAACGAAATGATTACGCTGGCTGACGTTGAGTA
CAGCAGACATCTGGCGGATAAGGAGGCCATATGGCAACGCTAA

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8556.58 Da
• Isoelectric Point: 5.5740

>AT242667 WP_003083775.1 NZ_CP095920:c142010-141783 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Nucleotide

• Length: 228 bp

>AT242667 NZ_OW849195:c1249922-1249623 [Enterobacter cloacae]
ATGGCAACGCTAAAAGAACTCATGGCACAACAGAGCGCGGAAAGTCAGGAGCGTATTGCGGCTAAAGTTGATGTAATACG
AAGAATTGTTGCCCTGAACCAACTGCGGGAAGAGCTCAATATTTCGCAGACAGAACTGGCCGCGGCAATGGGGGTAAAAC
AACCCACTGTGGCAAAAATCGAACAGCCGGGAAACGATCCCCGGCTTTCAACACTCAAACGCTATGTCAGTGCGCTCGGC
GGTGAAATGAGCATTGATGTGACGTTACCGAATGGGAAACGAATAGCGTTTCAGATTTGA

Structures

Toxin

• PDB: 6XRW

Antitoxin

• AlphaFold DB: A0A1C7BDS9