Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /SpoIISA(toxin)
Location 2354826..2355801 Replicon chromosome
Accession NZ_CP095874
Organism Bacillus sp. PGP15

Toxin (Protein)


Gene name spoIISA Uniprot ID A0A1J9UQ45
Locus tag MU858_RS12265 Protein ID WP_071756939.1
Coordinates 2354826..2355563 (+) Length 246 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A1S9U9H9
Locus tag MU858_RS12270 Protein ID WP_048529988.1
Coordinates 2355676..2355801 (+) Length 42 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MU858_RS12235 (MU858_12235) 2349992..2350075 + 84 Protein_2329 ABC transporter ATP-binding protein -
MU858_RS12240 (MU858_12240) 2350174..2350884 + 711 WP_247998946.1 class I SAM-dependent methyltransferase -
MU858_RS12245 (MU858_12245) 2351006..2351413 + 408 WP_071756918.1 VOC family protein -
MU858_RS12250 (MU858_12250) 2351458..2353143 - 1686 Protein_2332 alpha-keto acid decarboxylase family protein -
MU858_RS12255 (MU858_12255) 2353251..2353733 + 483 WP_048529992.1 MarR family winged helix-turn-helix transcriptional regulator -
MU858_RS12260 (MU858_12260) 2353900..2354637 + 738 WP_071756916.1 2,3-diphosphoglycerate-dependent phosphoglycerate mutase -
MU858_RS12265 (MU858_12265) 2354826..2355563 + 738 WP_071756939.1 type II toxin-antitoxin system SpoIISA family toxin Toxin
MU858_RS12270 (MU858_12270) 2355676..2355801 + 126 WP_048529988.1 hypothetical protein Antitoxin
MU858_RS12275 (MU858_12275) 2355877..2356053 + 177 WP_000852620.1 stage II sporulation protein SB -
MU858_RS12280 (MU858_12280) 2356072..2356460 - 389 Protein_2338 YxeA family protein -
MU858_RS12285 (MU858_12285) 2356677..2358146 + 1470 WP_071756914.1 beta-Ala-His dipeptidase -
MU858_RS12290 (MU858_12290) 2358732..2359202 - 471 WP_048529981.1 DUF5065 family protein -
MU858_RS12295 (MU858_12295) 2359656..2360315 + 660 WP_071756913.1 CatB-related O-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(9-243)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 246 a.a.        Molecular weight: 28369.00 Da        Isoelectric Point: 8.3034

>T242666 WP_071756939.1 NZ_CP095874:2354826-2355563 [Bacillus sp. PGP15]
VISNIRIGLFILAIVFLVLVFFYWRNEELYEEKKQRIRKTWYGLFIVSVTVYFMIKGIDLTLWKNLLMFTAMVIFVDIAF
ILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTTIIQNVNPAVFGTMEWHTEEDYTKSLNAFLDSYGEKIGAKI
VVFESAKELNTNFRGIRSQFSTIVPFEHIEQLNEQKAVQVENVGIIPVKIVSDVFIVIDGKKNNLQDRDFENVYNLTIHH
SYFSK

Download         Length: 738 bp

>T242666 NZ_OW849195:c1111154-1110936 [Enterobacter cloacae]
ATGTCTGAAAAACCACTCACAAAGGTCGATTATTTGATGCGCTTACGTCGTTGTCAGTCAATTGACACCCTCGAACGCGT
CATTGAAAAGAATAAATACGAGCTTTCTGATAATGAACTGGCGGTATTTTATTCAGCTGCTGACCATCGCCTCGCTGAGC
TAACGATGAATAAGTTATATGACAAAATCCCCACATCCGTGTGGAAATTTGTTCGTTGA

Antitoxin


Download         Length: 42 a.a.        Molecular weight: 4908.32 Da        Isoelectric Point: 3.9150

>AT242666 WP_048529988.1 NZ_CP095874:2355676-2355801 [Bacillus sp. PGP15]
VIKDYDNDFFKEDNEDATDFSLIKGDTLQQVEELEEELKRK

Download         Length: 126 bp

>AT242666 NZ_OW849195:c1111556-1111182 [Enterobacter cloacae]
ATGGACGAGTACTCGCCAAAACGGCATGATATCGCGCAGTTGAAATTTCTCTGCGAATCCTTGTACCATGACTGCCTTGC
CAATCTTGATGAAAGTAACCATGGCTGGGTAAACGATCCAACGTCTGCCATCAATTTACAGTTGAACGAGCTTATCGAGC
ATATCGCTACCTTCGCACTTAATTATAAAATTAAGTACAATGAAGATAATAAGCTCATTGAGCAAATTGATGAATACCTG
GACGACACCTTTATGTTGTTCAGTAGTTACGGCATTAACGCTCAGGATTTGCAAAAATGGCGCAAATCGGGAAACCGACT
ATTCCGCTGTTTCGTCAACGTGAGCAGAGCTAACCCCGTTAGCCTTTCCTGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1J9UQ45

Antitoxin

Source ID Structure
AlphaFold DB A0A1S9U9H9

References