Detailed information of TA system TA242664

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): phd-doc/HTH_IclR(antitoxin)
• Location: 3761879..3763592
• Replicon: chromosome
• Accession: NZ_CP095873
• Organism: Alcaligenes faecalis strain D334

Toxin (Protein)

• Gene name: doc
• Uniprot ID: -
• Locus tag: MXF72_RS17180
• Protein ID: WP_247966080.1
• Coordinates: 3762672..3763592 (-)
• Length: 307 a.a.

Antitoxin (Protein)

• Gene name: phd
• Uniprot ID: -
• Locus tag: MXF72_RS17175
• Protein ID: WP_083054297.1
• Coordinates: 3761879..3762682 (-)
• Length: 268 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MXF72_RS17155 (MXF72_17155)	3756954..3758441	-	1488	WP_247966076.1	aldehyde dehydrogenase	-
MXF72_RS17160 (MXF72_17160)	3758467..3759267	-	801	WP_247966077.1	aspartate dehydrogenase	-
MXF72_RS17165 (MXF72_17165)	3759279..3760988	-	1710	WP_247966078.1	thiamine pyrophosphate-binding protein	-
MXF72_RS17170 (MXF72_17170)	3760981..3761814	-	834	WP_247966079.1	SDR family oxidoreductase	-
MXF72_RS17175 (MXF72_17175)	3761879..3762682	-	804	WP_083054297.1	IclR family transcriptional regulator	Antitoxin
MXF72_RS17180 (MXF72_17180)	3762672..3763592	-	921	WP_247966080.1	alpha/beta hydrolase	Toxin
MXF72_RS17185 (MXF72_17185)	3763618..3764151	-	534	WP_026484076.1	cupin domain-containing protein	-
MXF72_RS17190 (MXF72_17190)	3764176..3764988	-	813	WP_247966081.1	SDR family oxidoreductase	-
MXF72_RS17195 (MXF72_17195)	3765253..3766788	-	1536	WP_009462680.1	3-hydroxyacyl-CoA dehydrogenase	-
MXF72_RS17200 (MXF72_17200)	3766820..3768052	-	1233	WP_137430802.1	CaiB/BaiF CoA-transferase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Alpha/beta hydrolase fold-1 (48-280)

Antitoxin

• Transcription regulator IclR, N-terminal (19-69)

Sequences

Toxin

Protein

• Length: 307 a.a.
• Molecular weight: 33195.16 Da
• Isoelectric Point: 6.5748

>T242664 WP_247966080.1 NZ_CP095873:c3763592-3762672 [Alcaligenes faecalis]
MNPLPGTLPLLSARETRYLQACLPLSTVDIGRGRQVAVRCAGDGEQWVVCLHGIGSGSASWLRVAQQLPPGLRLLAWDAP
GYGLSTPLEMDKPTALDYARRLQELLHVLEVKDFVLVGHSLGALMAGAYARHLDQGEMQALFLMSPAIGYGRPGLEQRRQ
AVWDQRMAQVASGDMGLMARQRHQRLLSEQATSENRELVLWIMASLHLAGYQQAVQMLCQEDLLTYLPLSSSVPVAVSCG
EVDVVTTPEACAGVARACSQHLQLVPQAGHASYVEQPGAMLEALQSLLGQTQALRSVATTRSSHEQ

Nucleotide

• Length: 921 bp

>T242664 NZ_OW849195:33039-33353 [Enterobacter cloacae]
ATGCATTTAATCTCAATGAAGGCAATTTTGGATGCGGTGATCCAGTTTCCGCAACACAGAGAGGAGCTTCTTTTTCTGGG
GCGAACCATCGAAAAGAGCCATTGCACGACGCCTGTTGCGCTAAGAAAAATCTTTCCAACGCTAGATAATTTGAAGTATC
TCGATAAGCATTATGTTATTGATATTGCTAACAACAACCTCAGAGTAGTGGCTCTCATATTCTTTGAAAGCCAAAAGTTT
TATGTGCGCCATGTTTTTACTCATAAGGAATATGACCGTTTTACGGAGAAACATCGCACTAAGGGGAAGAAATGA

Antitoxin

Protein

• Length: 268 a.a.
• Molecular weight: 29253.46 Da
• Isoelectric Point: 5.7053

>AT242664 WP_083054297.1 NZ_CP095873:c3762682-3761879 [Alcaligenes faecalis]
MSSELNKSDASADRYTVPALERGLLILTQFSRDQRTLGAPELARRLDLPRSTVFRLLSTLEGMGFVERTENGRDYRLSVG
VLRLGFEYVASLDVTELGRPVMERLCEQVRLPCNLVVRDLRSIVYVSRIAAPTPFASSVTVGTRLPAHATVLGHVLLSQL
SLTELKELYPEPELERFTSHTPADVPQLYEFCQAIREQGYALSEGYFESTISTIAAPVFNGAGKVAAALGVTAMAASFEG
ERLAEMIAQVKAAAAELSELVRHSPHS

Nucleotide

• Length: 804 bp

>AT242664 NZ_OW849195:33350-33769 [Enterobacter cloacae]
ATGATGATCGTAGCTGATGCAATGAAAGCAACGCATGCCCTTGTCGCGGCGGTTCCTTTATTGGGTGAACATCCAAACGA
GAAAGATTACCAGGACGCACTTGAGCTGGTTGAGTATTTACTGATGAACGAACCTGGCAGCCCTTTGCTGGATATCGTAT
GTGCAAGAATTCGTCGTTACGAAGCCAATCGACCCGAAATTGTCGCCTTACGCCAGGAGATGGAATCTGTCCCAGTGGGC
ATTGCCGTTTTAAGAACCCTTATGGATCAATACAAACTGACTATTTCGGATTTTCAGGATGAAATTGGCAGTAAATCAAT
GGTTTCAAGGGTGTTGAACGGTCAACGTCAGCTGACGTTGAACCATATAAAAAAACTGGCTGCTCGCTTTGGGGTATCGC
CTGCGCTGTTCATTGAATGA