Detailed information of TA system TA242663

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 417563..418199
• Replicon: chromosome
• Accession: NZ_CP095872
• Organism: Acinetobacter schindleri strain H4-3-C1

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: MYA84_RS02060
• Protein ID: WP_048881826.1
• Coordinates: 417813..418199 (+)
• Length: 129 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: I4ZVX5
• Locus tag: MYA84_RS02055
• Protein ID: WP_008302635.1
• Coordinates: 417563..417820 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MYA84_RS02035 (MYA84_02030)	413034..414041	+	1008	WP_004809777.1	DNA-directed RNA polymerase subunit alpha	-
MYA84_RS02040 (MYA84_02035)	414060..414425	+	366	WP_004786886.1	50S ribosomal protein L17	-
MYA84_RS02045 (MYA84_02040)	414645..416150	+	1506	WP_048881824.1	NAD(P)/FAD-dependent oxidoreductase	-
MYA84_RS02050 (MYA84_02045)	416214..417386	-	1173	WP_048881825.1	acyl-CoA dehydrogenase family protein	-
MYA84_RS02055 (MYA84_02050)	417563..417820	+	258	WP_008302635.1	succinate dehydrogenase assembly factor 2	Antitoxin
MYA84_RS02060 (MYA84_02055)	417813..418199	+	387	WP_048881826.1	hypothetical protein	Toxin
MYA84_RS02065 (MYA84_02060)	418747..419787	+	1041	WP_004809769.1	hypothetical protein	-
MYA84_RS02070 (MYA84_02065)	419853..420425	+	573	WP_026056805.1	rhombosortase	-
MYA84_RS02075 (MYA84_02070)	420602..422797	+	2196	WP_048881827.1	TRAP transporter large permease subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Flavinator of succinate dehydrogenase (10-82)

Sequences

Toxin

Protein

• Length: 129 a.a.
• Molecular weight: 15522.54 Da
• Isoelectric Point: 9.6431

>T242663 WP_048881826.1 NZ_CP095872:417813-418199 [Acinetobacter schindleri]
MDNRCYQLKRSLLALAFQFFIFIVLMFVMYQLLPLWLWGICLVAGLIIYHLFYRKRPQIAQFEYLDGREWTITHHDQRIQ
RAQISHVIDHQAYLVVYFQHAKVPPLLIWCDQLPTQQWKSLKVLTKMI

Nucleotide

• Length: 387 bp

>T242663 NZ_OW849099:c4684789-4684415 [Citrobacter freundii]
ATGGTCAAAGGATCCGCGCTTTTTGATACCAACATCCTCATCGATCTGTTTAGTGGGAGAAATGAAGCAAAACTAGCGAT
AGAAACATGGCCGCCGCAGAATGCAATCAGCCTCATTACATGGATGGAGGTGATGGTGGGTGCAAAAAAATACCATCAGG
AAGCCCGTACTCGTGTTGCGCTAGGTGCTTTTAACGTGATCGGCGTTTCACAGGATATTGCTGAACGAAGCGTGAGTATC
AGACAGGAATATGGGATGAAATTGCCGGATGCCATTATTTTGGCAACAGCACAGATTCATCGTCTTACGCTGGTTACGCG
AAATACTAAGGATTTTGCAGGCCTATCCGGTGTGGTCACACCGTATACATTATAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 10254.70 Da
• Isoelectric Point: 4.4898

>AT242663 WP_008302635.1 NZ_CP095872:417563-417820 [Acinetobacter schindleri]
MTEDISLEERKVIYRARRGLKELDVYFDPYVKNCYLTADPFEKEMFAELVAQEDPDLLDWFMEVSEPPRPELREFINKLK
HYVHG

Nucleotide

• Length: 258 bp

>AT242663 NZ_OW849099:c4685031-4684789 [Citrobacter freundii]
ATGATGACTGGGATGGATATGGGCAGAATTTTACTCGATTTATCAGATGAAGTGATTAAACGTCTTGATGATCTCAAGGT
GCAGCGCAACCTGCCGCGAGCAGAACTTTTACGGGAGGCCGTTGAACAGTATCTTGAGAGGCAGGATCAGGCTGAAACCA
CAATTTCACGTGCTCTTGGGCTGTGGCAAGGCTGTGAGGAAGATGGTGTTGAATACCAGCGTAAACTCCGTGAGGAATGG
TAA

Structures

Antitoxin

• AlphaFold DB: A0A1P8PMS5