Detailed information of TA system TA242659

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/-
• Location: 2954870..2955523
• Replicon: chromosome
• Accession: NZ_CP095867
• Organism: Acinetobacter nosocomialis strain 11J360

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: A0A7S8XRH8
• Locus tag: MW889_RS13950
• Protein ID: WP_025466887.1
• Coordinates: 2954870..2955259 (-)
• Length: 130 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: N8SCE2
• Locus tag: MW889_RS13955
• Protein ID: WP_002049719.1
• Coordinates: 2955266..2955523 (-)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MW889_RS13935 (MW889_13945)	2949984..2952179	-	2196	WP_033854463.1	TRAP transporter large permease subunit	-
MW889_RS13940 (MW889_13950)	2952367..2952933	-	567	WP_004711824.1	rhombosortase	-
MW889_RS13945 (MW889_13955)	2953017..2954102	-	1086	WP_002049690.1	hypothetical protein	-
MW889_RS13950 (MW889_13960)	2954870..2955259	-	390	WP_025466887.1	hypothetical protein	Toxin
MW889_RS13955 (MW889_13965)	2955266..2955523	-	258	WP_002049719.1	succinate dehydrogenase assembly factor 2	Antitoxin
MW889_RS13960 (MW889_13970)	2955713..2956885	+	1173	WP_002049748.1	acyl-CoA dehydrogenase family protein	-
MW889_RS13965 (MW889_13975)	2956934..2958424	-	1491	WP_006582603.1	NAD(P)/FAD-dependent oxidoreductase	-
MW889_RS13970 (MW889_13980)	2958606..2958983	-	378	WP_002049717.1	50S ribosomal protein L17	-
MW889_RS13975 (MW889_13985)	2959002..2960009	-	1008	WP_002049752.1	DNA-directed RNA polymerase subunit alpha	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Flavinator of succinate dehydrogenase (10-82)

Sequences

Toxin

Protein

• Length: 130 a.a.
• Molecular weight: 15624.70 Da
• Isoelectric Point: 10.0990

>T242659 WP_025466887.1 NZ_CP095867:c2955259-2954870 [Acinetobacter nosocomialis]
MVNHLNFKLKYSRFAIIFQFFIGLSLVVLFYQLLPILWWLVTVSLLFISFIFFLKRPQLAQIAHLDQKLWSLSFHSEQTI
SRVEILKIIDYQIFIVVYFEGHKTLTSVIWFDQMPLSQWKQLKTLEKFY

Nucleotide

• Length: 390 bp

>T242659 NZ_OW849099:2374731-2374907 [Citrobacter freundii]
GTGAAGCAAAGTGAGTTTAGACGCTGGCTTGAATCTCAGGGAGTTGCTGTTACAAACGGCTCAAATCATCTGAAACTGAG
ATATCAGGGAAGGCGTAGCGTTATGCCCAGACATCCAGGTGATGAAATAAAAGAAGCCTTGCGAAAAGCGATTATTAAGC
AGCTTGACTTACAGTAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 10278.71 Da
• Isoelectric Point: 4.7620

>AT242659 WP_002049719.1 NZ_CP095867:c2955523-2955266 [Acinetobacter nosocomialis]
MSEEMTLEERKVVYRARRGLKEIDVYFDPYVKNYYLKADPAEKALFAELVEQEDPDLLDWFMEVSEPPRTELRDFIHKLK
HYVHG

Nucleotide

• Length: 258 bp

>AT242659 NZ_OW849099:2374954-2375370 [Citrobacter freundii]
ATGCGTTATCCTGTTACTCTAACACCGGCAGTGGAAGGTGGGTTTGTGGTTTCTTTCCCGGATATTCCGGAAGCATTAAC
TCAGGGAAATACTCGCCATGACGCTTTGCAGGCCGCGCAGGCGGCATTGATTACCGCTTTTGAATTCTATTTCGACGACA
ACGAGGCGATTCCACTCCCTTCAGCGGTTAGCGCTGAAGATGACTACGTAGAAATACCGCTGAGCGTTGCGTCTAAGGTT
CTTCTGCTGAATGCCTTCCTTGAATCAAAAATCACCCAGCAGGAGCTGGCGAACAGGATCGGCAGACCTAAGCAGGAGAT
CACCCGTTTATTTGATTTAAAGCACACGACAAAAATTGATGCCGTGCAGATTGCTGCGCGCGCCTTAGGCAAAGAGCTGG
CGTTAACGATGTTGTAA

Structures

Antitoxin

• AlphaFold DB: A0A0Q1QI86