Detailed information of TA system TA242658

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-couple_hipB
• Location: 1575132..1576768
• Replicon: chromosome
• Accession: NZ_CP095867
• Organism: Acinetobacter nosocomialis strain 11J360

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: A0A2T7FM76
• Locus tag: MW889_RS07440
• Protein ID: WP_004887176.1
• Coordinates: 1575437..1576768 (-)
• Length: 444 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: MW889_RS07435
• Protein ID: WP_004887177.1
• Coordinates: 1575132..1575440 (-)
• Length: 103 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MW889_RS07420 (MW889_07440)	1571141..1571659	-	519	WP_004887184.1	GNAT family N-acetyltransferase	-
MW889_RS07425 (MW889_07445)	1571846..1573786	+	1941	WP_004887182.1	ATP-binding protein	-
MW889_RS07430 (MW889_07450)	1573856..1574404	-	549	WP_004887179.1	TetR/AcrR family transcriptional regulator	-
MW889_RS07435 (MW889_07455)	1575132..1575440	-	309	WP_004887177.1	helix-turn-helix domain-containing protein	Antitoxin
MW889_RS07440 (MW889_07460)	1575437..1576768	-	1332	WP_004887176.1	HipA domain-containing protein	Toxin
MW889_RS07445 (MW889_07465)	1577064..1577504	+	441	WP_004887174.1	HD domain-containing protein	-
MW889_RS07450 (MW889_07470)	1577540..1578184	-	645	WP_004887171.1	hypothetical protein	-
MW889_RS07455 (MW889_07475)	1578196..1579167	-	972	WP_079377104.1	5'/3'-nucleotidase SurE	-
MW889_RS07460 (MW889_07480)	1579400..1580563	-	1164	WP_004887169.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (167-359)

Antitoxin

• Cro/C1-type helix-turn-helix domain (36-83)

Sequences

Toxin

Protein

• Length: 444 a.a.
• Molecular weight: 51202.34 Da
• Isoelectric Point: 4.9790

>T242658 WP_004887176.1 NZ_CP095867:c1576768-1575437 [Acinetobacter nosocomialis]
MKKLTIQALLNKNWIDIAELKLLKPKLGSASASELEYELDYAIQYLDRRDEHACSLSLPVQILIKHESDTWFGFLDDIVP
SGAARRYWVNYLDLQRLTYAEQESILLEKGGMAPVGNLRIKEALPPLNPESTLHLRYFSKEDVAERNIDFLEYAQQMGAI
SGGATGAGGEAPKLLIRVSPEQKVWIDTYQEKFDQPDQHYLVKFPRNKRSEIDCDILRAEYYYYQILNELGFNTIETTQM
QLIEGTKYPSLWLPRFDTEWCDQYWHRYGLESVYSVLNKSSGSHLNHFEVIEDLCRLLTSIDSDFDVPQFICEWLQRDLL
NIIFGNSDNHGRNTSFLKKSGKIYLSPIYDFAPMKADPEVVTRSTTWGSPYEEGGEYRWAQITQKLAPWCDPDLSLATLR
TLANNLLGLKQRLVDKGVPKQIIEMPALSFDYIEAKLKRWELL

Nucleotide

• Length: 1332 bp

>T242658 NZ_OW849099:2032449-2032552 [Citrobacter freundii]
GGCAGGGTAACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin

Protein

• Length: 103 a.a.
• Molecular weight: 11630.58 Da
• Isoelectric Point: 10.1265

>AT242658 WP_004887177.1 NZ_CP095867:c1575440-1575132 [Acinetobacter nosocomialis]
MNVKNQTKDRQQILIDLYKQYLLSEITLGQLLSYLRKNVLGLSQEQYANLVGISRRTLTDIEQDKGKLTQSVLDKVFKPL
GLKAGLVPTHEHIVSKIIKPNE

Nucleotide

• Length: 309 bp

>AT242658 NZ_OW849099:c2032555-2032414 [Citrobacter freundii]
GATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGG
CATTAATGCAGGCTAAGTTACCCTGCCATTTAAGAATAGATGACAGCGCCAGGTTTTCCAGT

Structures

Toxin

• AlphaFold DB: A0A2T7FM76