Detailed information of TA system TA242657

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/ParE-RHH
• Location: 3218373..3218917
• Replicon: chromosome
• Accession: NZ_CP095864
• Organism: Gordonia sp. PP30

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: MYK68_RS14845
• Protein ID: WP_247864457.1
• Coordinates: 3218618..3218917 (+)
• Length: 100 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: -
• Locus tag: MYK68_RS14840
• Protein ID: WP_247864456.1
• Coordinates: 3218373..3218621 (+)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MYK68_RS14825 (MYK68_14825)	3213511..3214539	+	1029	WP_247864451.1	ABC transporter substrate-binding protein	-
MYK68_RS14830 (MYK68_14830)	3214543..3217479	+	2937	WP_247864453.1	DEAD/DEAH box helicase	-
MYK68_RS14835 (MYK68_14835)	3217479..3218306	+	828	WP_247864455.1	hypothetical protein	-
MYK68_RS14840 (MYK68_14840)	3218373..3218621	+	249	WP_247864456.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
MYK68_RS14845 (MYK68_14845)	3218618..3218917	+	300	WP_247864457.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
MYK68_RS14850 (MYK68_14850)	3219088..3220017	+	930	WP_247864459.1	diiron oxygenase	-
MYK68_RS14855 (MYK68_14855)	3220014..3220700	+	687	WP_247864461.1	DUF4873 domain-containing protein	-
MYK68_RS14860 (MYK68_14860)	3220811..3221812	+	1002	WP_247864463.1	IS481 family transposase	-
MYK68_RS14865 (MYK68_14865)	3221885..3223126	-	1242	WP_247864465.1	3,4-dihydroxy-2-butanone-4-phosphate synthase	-
MYK68_RS14870 (MYK68_14870)	3223123..3223620	-	498	WP_247864466.1	flavin reductase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	3220811..3221812	1001

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-90)

Antitoxin

• Antitoxin ParD (1-78)

Sequences

Toxin

Protein

• Length: 100 a.a.
• Molecular weight: 11274.65 Da
• Isoelectric Point: 5.5481

>T242657 WP_247864457.1 NZ_CP095864:3218618-3218917 [Gordonia sp. PP30]
MKRVLFTALARRDIESIWDFTAATWDADQADYYTDSIEECCMRVAAGTVAGKPTTNPPGYRKAFAGSHLVFYRETEDIVT
IVRILHQRQDVEHHLSDSP

Nucleotide

• Length: 300 bp

>T242657 NZ_OW849099:809472-809879 [Citrobacter freundii]
GTGGTCCAGTGGCAATCTGATTTACGCGTATCATGGCGCGCGCAGTGGCTTTCACTGCTAATTCATGGGCTGGTCGCGGT
GTTTATTTTATTGATGCCCTGGCCATTGAGCTACACCCCATTATGGCTGGTTTTGCTCTCTCTGGTGGTATTCGATAGCG
TTCGCAGTCAGCGTCGAATCAACGCTTGTCAGGGTGAGATTCGGCTGTTGATGGATGGTCGTCTGCGCTGGCAAGGGCAA
GAGTGGTCTATCGTTAGCGCCCCCTGGATGGTTAAAACAGGCATGATGCTGCGTTTGCGCTCTGATGCCGGAAAACGTCA
ACATTTGTGGCTGGCGGCAGACAGTATGGATGATGCAGAGTGGCGGGATTTACGGCGGTTGATGCTGCAAAAGGCGAAGC
AGAAGTAG

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 9154.04 Da
• Isoelectric Point: 5.1358

>AT242657 WP_247864456.1 NZ_CP095864:3218373-3218621 [Gordonia sp. PP30]
MARNTSVILGDHFADFVGAQVESGRYGSASDVIRAALRLLEEHETQVQNLRDALRAGEESGDAQPFDFEAFKSRKRAERR
DS

Nucleotide

• Length: 249 bp

>AT242657 NZ_OW849099:809225-809491 [Citrobacter freundii]
ATGGATATTAACAACAAAGCACGTATTCATTGGGCATGCCGCCGCGGTATGCGCGAGCTGGACATCTCGATCATGCCGTT
TTTCGAACATGAATATGACAGCTTAAGTGACGAAGAAAAACGTATCTTTATCCGTCTGCTAGAATGTGATGATCCAGATT
TATTTAACTGGTTGATGAATCATGGGAAACCAGCTGATGCTGAGCTGGAGCAGATGGTGCGACTTATCCAGACACGGAAT
CGGGAACGTGGTCCAGTGGCAATCTGA