Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 540930..541568 Replicon chromosome
Accession NZ_CP095856
Organism Escherichia coli strain EC6563

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag MYG04_RS02725 Protein ID WP_000813794.1
Coordinates 540930..541106 (+) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag MYG04_RS02730 Protein ID WP_001270286.1
Coordinates 541152..541568 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MYG04_RS02705 (536549) 536549..537724 - 1176 WP_001236265.1 BenE family transporter YdcO -
MYG04_RS02710 (537816) 537816..538352 + 537 WP_000429155.1 DNA-binding transcriptional regulator SutR -
MYG04_RS02715 (538425) 538425..540386 + 1962 WP_001301045.1 23S rRNA 5-hydroxycytidine C2501 synthase -
MYG04_RS02720 (540478) 540478..540708 - 231 WP_000494244.1 YncJ family protein -
MYG04_RS02725 (540930) 540930..541106 + 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
MYG04_RS02730 (541152) 541152..541568 + 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
MYG04_RS02735 (541647) 541647..543053 + 1407 WP_000760626.1 PLP-dependent aminotransferase family protein -
MYG04_RS02740 (543298) 543298..544443 + 1146 WP_000047424.1 ABC transporter substrate-binding protein -
MYG04_RS02745 (544461) 544461..545474 + 1014 WP_000220396.1 ABC transporter ATP-binding protein -
MYG04_RS02750 (545475) 545475..546416 + 942 WP_247777698.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T242629 WP_000813794.1 NZ_CP095856:540930-541106 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

>T242629 NZ_OW849064:c4205067-4204915 [Escherichia coli]
ATGAAGCAGCATAAGGCGATGATTGTCGCCCTGATCGTCATCTGTATCACCGCCGTAGTGGCGGCGCTGGTAACGAGAAA
AGACCTCTGTGAGGTTCACATCCGAACTGGCCAGACGGAGGTTGCTGTTTTCACGGCTTACGAATCCGAGTAA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT242629 WP_001270286.1 NZ_CP095856:541152-541568 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp

>AT242629 NZ_OW849064:4205116-4205173 [Escherichia coli]
GTTCTGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References