Detailed information of TA system TA242624

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-Phd
• Location: 4088532..4089091
• Replicon: chromosome
• Accession: NZ_CP095851
• Organism: Rhodococcus pyridinivorans strain YC-MTN

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: MYP14_RS19295
• Protein ID: WP_080678595.1
• Coordinates: 4088846..4089091 (+)
• Length: 82 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: MYP14_RS19290
• Protein ID: WP_024102980.1
• Coordinates: 4088532..4088816 (+)
• Length: 95 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MYP14_RS19265 (MYP14_19265)	4083735..4084361	+	627	WP_231913210.1	TetR/AcrR family transcriptional regulator	-
MYP14_RS19270 (MYP14_19270)	4084358..4084786	+	429	WP_024102975.1	HIT family protein	-
MYP14_RS19275 (MYP14_19275)	4084791..4086392	+	1602	WP_039585873.1	L-lactate permease	-
MYP14_RS19280 (MYP14_19280)	4086469..4087497	+	1029	WP_033096849.1	Dyp-type peroxidase	-
MYP14_RS19285 (MYP14_19285)	4087494..4088312	+	819	WP_247848529.1	family 1 encapsulin nanocompartment shell protein	-
MYP14_RS19290 (MYP14_19290)	4088532..4088816	+	285	WP_024102980.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
MYP14_RS19295 (MYP14_19295)	4088846..4089091	+	246	WP_080678595.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
MYP14_RS19300 (MYP14_19300)	4089148..4089627	-	480	WP_006551854.1	MarR family transcriptional regulator	-
MYP14_RS19305 (MYP14_19305)	4089686..4090435	-	750	WP_024102983.1	cutinase family protein	-
MYP14_RS19310 (MYP14_19310)	4090585..4091247	-	663	WP_033096847.1	alpha-ketoglutarate-dependent dioxygenase AlkB	-
MYP14_RS19315 (MYP14_19315)	4091368..4092198	+	831	WP_006551851.1	SDR family oxidoreductase	-
MYP14_RS19320 (MYP14_19320)	4092243..4093214	+	972	WP_006551850.1	phosphotriesterase	-
MYP14_RS19325 (MYP14_19325)	4093251..4093970	-	720	WP_247848530.1	2OG-Fe(II) oxygenase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (29-80)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-71)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 8971.32 Da
• Isoelectric Point: 10.3368

>T242624 WP_080678595.1 NZ_CP095851:4088846-4089091 [Rhodococcus pyridinivorans]
MARSAARAMARSLPEKVATAVYEFVTGPLLENPKRVGKPLNPPLAPAYSARRGEYRVLYLIDDANRTVEVTAISHRADAY
R

Nucleotide

• Length: 246 bp

>T242624 NZ_OW849064:3494392-3494703 [Escherichia coli]
ATGCTCTTCATCGAAACGGAAATTTTTACTGAAGATGTTCAAAAACTGCTGAACGACGATGAATTCAGTCGTTTTCAGTT
TTTCCTGGCCTTGAATCCTGACTATGGTGAGGTAATACCTGAAACTGGTGGGTTAAGAAAGGTTCGATGGGTCTCAGGAG
GAAAGGGGAAACGTGCTGGTGTCAGGGTTATTTACTTTCATCAGGTTAAACATTATGAGATCAGATTACTGCTTATTTAT
CGTAAGGGTATTAAAGATGATCTGTCTCCCCAGGAAAAAGCAATGCTCCGGTTGTTAAATACGAGGTGGTAA

Antitoxin

Protein

• Length: 95 a.a.
• Molecular weight: 10494.56 Da
• Isoelectric Point: 4.2336

>AT242624 WP_024102980.1 NZ_CP095851:4088532-4088816 [Rhodococcus pyridinivorans]
MTTLPVADARAQLSRLVDEAERTHERFEITRNGHRAAVLLGADDYDAMQETIAVLSDTDLLRAHVEGRTEVESGDVVDVQ
ELTQLMRDARSSEE

Nucleotide

• Length: 285 bp

>AT242624 NZ_OW849064:3494704-3494994 [Escherichia coli]
ATGGATAAGGCACTTTTTGAGCGGTTGACTCACAGCATGGCCCAGATGAATGAAATTATTGAAGGAACGCGACAGCCTTC
ACGGACTTTTGAAGTTGATGCTATGAAAATCAAAGAAATACGCCGCGCTTCAGGGTTGTCACAATCTAAATTTGCCGATC
TTATTTCCGTAAGCGTAGACACGTTGCGTAACTGGGAGCAGGGGCGACGTTCACCGACCGGGCCTGCAAAGGCTTTGCTG
CGAGCGATTGCCAATGATCCGCAACATGTGCTGCAAGCACTTAACCGTTAG