Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1796622..1797424 Replicon chromosome
Accession NZ_CP095845
Organism Sphingopyxis sp. GC21

Toxin (Protein)


Gene name TacT3 Uniprot ID -
Locus tag MU856_RS08670 Protein ID WP_263588885.1
Coordinates 1796622..1797149 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID -
Locus tag MU856_RS08675 Protein ID WP_263588886.1
Coordinates 1797146..1797424 (-) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MU856_RS08645 1793806..1794333 + 528 WP_263588881.1 helix-turn-helix transcriptional regulator -
MU856_RS08650 1794397..1794723 + 327 WP_263588882.1 hypothetical protein -
MU856_RS08655 1794765..1795238 + 474 WP_263588883.1 hypothetical protein -
MU856_RS08660 1795235..1795381 - 147 WP_263588884.1 hypothetical protein -
MU856_RS08665 1795403..1796194 + 792 WP_263588973.1 JAB domain-containing protein -
MU856_RS08670 1796622..1797149 - 528 WP_263588885.1 GNAT family N-acetyltransferase Toxin
MU856_RS08675 1797146..1797424 - 279 WP_263588886.1 DUF1778 domain-containing protein Antitoxin
MU856_RS08680 1797480..1797725 - 246 WP_263588887.1 hypothetical protein -
MU856_RS08685 1797915..1798160 + 246 WP_263588888.1 helix-turn-helix transcriptional regulator -
MU856_RS08690 1798494..1799021 + 528 WP_263588889.1 MbcA/ParS/Xre antitoxin family protein -
MU856_RS08695 1799018..1799689 + 672 WP_263588890.1 RES family NAD+ phosphorylase -
MU856_RS08700 1799741..1799884 + 144 WP_263588891.1 hypothetical protein -
MU856_RS08705 1800005..1800226 - 222 WP_263588892.1 response regulator -
MU856_RS08710 1800253..1800438 + 186 WP_263588893.1 hypothetical protein -
MU856_RS08715 1800826..1801083 - 258 WP_263588974.1 DUF6429 family protein -
MU856_RS08720 1801210..1801611 - 402 WP_263588894.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 1724898..1878952 154054


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(11-87)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19122.96 Da        Isoelectric Point: 7.3249

>T242622 WP_263588885.1 NZ_CP095845:c1797149-1796622 [Sphingopyxis sp. GC21]
MTLPDWREEAIAKAHDCHTFDCGDMAMNDFLRRYARQSHEQNASKTFCAIDASAPNRVLGFYTITPSAVAHEDVPTRMTK
GLAQHEIAGFRLARIATDIAVAGQGLGGQLLVSAALRCLRIAEQAGGRLLIIDAKNERAAEWYASYGAEPLQDKPLTLVM
PLQLFAGGLQARKLI

Download         Length: 528 bp

>T242622 NZ_OW849064:c3029156-3029049 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10024.67 Da        Isoelectric Point: 10.6525

>AT242622 WP_263588886.1 NZ_CP095845:c1797424-1797146 [Sphingopyxis sp. GC21]
MPRAAIDDNKRMNLRVSAEAKAKLVRAAALRNTDLTNFVMQTALREAEAVIEAAEAVRVSARDYARVLDLLENPPKPNAR
LKAAMAALPANL

Download         Length: 279 bp

>AT242622 NZ_OW849064:3029205-3029270 [Escherichia coli]
GTCTAGATGCAAGAATGGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References