Detailed information of TA system TA242621

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RHH(antitoxin)
• Location: 968991..969550
• Replicon: chromosome
• Accession: NZ_CP095845
• Organism: Sphingopyxis sp. GC21

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: MU856_RS04595
• Protein ID: WP_263588468.1
• Coordinates: 968991..969284 (-)
• Length: 98 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: MU856_RS04600
• Protein ID: WP_263588469.1
• Coordinates: 969281..969550 (-)
• Length: 90 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MU856_RS04575	963999..965186	-	1188	WP_263588466.1	acetyl-CoA C-acyltransferase	-
MU856_RS04580	965353..966807	+	1455	WP_263588467.1	coniferyl aldehyde dehydrogenase	-
MU856_RS04590	967535..968608	-	1074	Protein_907	recombinase family protein	-
MU856_RS04595	968991..969284	-	294	WP_263588468.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
MU856_RS04600	969281..969550	-	270	WP_263588469.1	ribbon-helix-helix domain-containing protein	Antitoxin
MU856_RS04605	970231..972306	+	2076	WP_263588470.1	ParB/RepB/Spo0J family partition protein	-
MU856_RS04610	972401..973366	-	966	WP_263588471.1	CDF family Co(II)/Ni(II) efflux transporter DmeF	-
MU856_RS04615	973378..973653	-	276	WP_263588472.1	metal/formaldehyde-sensitive transcriptional repressor	-
MU856_RS04620	974032..974331	+	300	WP_263588473.1	DUF736 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-90)

Antitoxin

• Ribbon-helix-helix protein, CopG (8-45)

Sequences

Toxin

Protein

• Length: 98 a.a.
• Molecular weight: 11399.08 Da
• Isoelectric Point: 8.9473

>T242621 WP_263588468.1 NZ_CP095845:c969284-968991 [Sphingopyxis sp. GC21]
MRIKWTGKASSDLVRLHEHLRPVAPEAAARVVQQLARAPDRLLDYPRIGEKLDAYAPREVRRIIVGNYELRYEIADATIF
ILRLWHCRENRSFESDE

Nucleotide

• Length: 294 bp

>T242621 NZ_OW849064:c2926179-2925652 [Escherichia coli]
ATGGATGATCTGACGATAGAGATTCTGACCGATGATGCAGATTATGATCTACAGCGATTCGACTGCGGCGAGGAAGCATT
AAATCTCTTTCTGACGACACATCTGGTTCGTCAACATCGCAATAAAATTCTGCGAGCGTATATCCTGTGTCGCAACACTC
CAGAACGTCAGGTGCTGGGATATTACACATTATCCGGCAGTTGTTTTGAACGAGCCGCACTGCCCTCGAAATCGAAACAG
AAAAAAATTCCCTACAAAAATATTCCCAGCGTAACTCTTGGGCGTCTGGCAATTGATCGTTCATTACAGGGGCAGGGATG
GGGAGCAACACTGGTTGCTCATGCCATGAAAGTTGTCTGGTCAGCCTCTTTAGCGGTAGGTATTCACGGTCTTTTTGTCG
AGGCGCTGAATGAAAAAGCCCATACGTTTTATCAGTCGCTGGGCTTTATCCCATTGGTCGGAGAAAACGAAAATGCGTTA
TTTTTCCCGACCAAATCTATAGAGCTACTTTTTACACCAGACGATTAA

Antitoxin

Protein

• Length: 90 a.a.
• Molecular weight: 9853.29 Da
• Isoelectric Point: 4.8259

>AT242621 WP_263588469.1 NZ_CP095845:c969550-969281 [Sphingopyxis sp. GC21]
MATDTKVLTAHVPIALVEKVEAMAARLERSRGWVMKQALAAWVDQEEERHRMTLEALEDVDAGRVIDHQAIQAWADSLGT
DKPLPPPVA

Nucleotide

• Length: 270 bp

>AT242621 NZ_OW849064:c2926452-2926186 [Escherichia coli]
ATGTCTGCTGTTAAAAAGCAGCGTATTGATCTGCGTTTAACTGACGATGACAAAAGTATGATTGAGGAAGCGGCAGCGAT
ATCTAATCAGTCCGTCAGCCAATTTATGTTGAACAGCGCTTCGCAGCGAGCTGCGGAAGTGATTGAACAGCATCGGCGGA
TGATTCTCACTGAGGAATCCTGGACGCGGGTGATGGATGCGCTGAGTAATCCACCGTCACCAGGTGAAAAGCTAAAACGT
GCGGCAAAACGTCTTCAGGGAATGTAA