Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | PanAT/DUF4065(antitoxin) |
| Location | 3262354..3263398 | Replicon | chromosome |
| Accession | NZ_CP095843 | ||
| Organism | Escherichia fergusonii strain EF21QZZ116 | ||
Toxin (Protein)
| Gene name | panT | Uniprot ID | - |
| Locus tag | MYF53_RS15780 | Protein ID | WP_249895956.1 |
| Coordinates | 3262850..3263398 (+) | Length | 183 a.a. |
Antitoxin (Protein)
| Gene name | panA | Uniprot ID | A0A839B6W4 |
| Locus tag | MYF53_RS15775 | Protein ID | WP_000287252.1 |
| Coordinates | 3262354..3262827 (+) | Length | 158 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MYF53_RS15750 (3258431) | 3258431..3258799 | + | 369 | WP_000002903.1 | diacylglycerol kinase | - |
| MYF53_RS15755 (3258909) | 3258909..3259517 | + | 609 | WP_249895955.1 | transcriptional repressor LexA | - |
| MYF53_RS15760 (3259590) | 3259590..3260915 | + | 1326 | WP_046076452.1 | MATE family efflux transporter DinF | - |
| MYF53_RS15765 (3261047) | 3261047..3261256 | + | 210 | WP_001030605.1 | CsbD family protein | - |
| MYF53_RS15770 (3261307) | 3261307..3261822 | - | 516 | WP_000426182.1 | zinc uptake transcriptional repressor Zur | - |
| MYF53_RS15775 (3262354) | 3262354..3262827 | + | 474 | WP_000287252.1 | DUF4065 domain-containing protein | Antitoxin |
| MYF53_RS15780 (3262850) | 3262850..3263398 | + | 549 | WP_249895956.1 | hypothetical protein | Toxin |
| MYF53_RS15785 (3263432) | 3263432..3263704 | - | 273 | WP_001093911.1 | pyocin activator PrtN family protein | - |
| MYF53_RS15790 (3263741) | 3263741..3264313 | - | 573 | WP_249896298.1 | 3'-5' exonuclease | - |
| MYF53_RS15795 (3264313) | 3264313..3265080 | - | 768 | WP_249895957.1 | hypothetical protein | - |
| MYF53_RS15800 (3265083) | 3265083..3265274 | - | 192 | WP_001014290.1 | hypothetical protein | - |
| MYF53_RS15805 (3265276) | 3265276..3265830 | - | 555 | WP_040092683.1 | ead/Ea22-like family protein | - |
| MYF53_RS15810 (3265827) | 3265827..3266066 | - | 240 | WP_000476212.1 | hypothetical protein | - |
| MYF53_RS15815 (3266059) | 3266059..3266262 | - | 204 | WP_000111288.1 | hypothetical protein | - |
| MYF53_RS15820 (3266259) | 3266259..3266621 | - | 363 | WP_001242718.1 | phage protein | - |
| MYF53_RS15825 (3266612) | 3266612..3267148 | - | 537 | WP_000008248.1 | 5'-deoxynucleotidase | - |
| MYF53_RS15830 (3267277) | 3267277..3268101 | - | 825 | WP_000081287.1 | DUF2303 family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 3258909..3309085 | 50176 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 183 a.a. Molecular weight: 19904.36 Da Isoelectric Point: 4.5732
>T242614 WP_249895956.1 NZ_CP095843:3262850-3263398 [Escherichia fergusonii]
MSHNSDIYKLIGAAAGVENGRSEASLNSTDSQEQAFESAFEPSNHERVDDSSSENKAILEAEEFGSNTGALHEFMQQNRM
DSLQAQLDMLKSQVRDKIADATGKEIDNELRTKMASFTVWFMSCWCLFVAGMFVSFLIAHEGKPPVEAIVALLGTSTISI
VGLVGFVVSGLFKSRKDGDKEK
MSHNSDIYKLIGAAAGVENGRSEASLNSTDSQEQAFESAFEPSNHERVDDSSSENKAILEAEEFGSNTGALHEFMQQNRM
DSLQAQLDMLKSQVRDKIADATGKEIDNELRTKMASFTVWFMSCWCLFVAGMFVSFLIAHEGKPPVEAIVALLGTSTISI
VGLVGFVVSGLFKSRKDGDKEK
Download Length: 549 bp
>T242614 NZ_OW849064:c1325477-1325223 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAGCAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACACCATTTGAAGGTAAGGGGAAACCAGAACCCCTGAAACATAACTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCTTCTGGTATACGCGGTTACTGATGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAGCAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACACCATTTGAAGGTAAGGGGAAACCAGAACCCCTGAAACATAACTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCTTCTGGTATACGCGGTTACTGATGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA
Antitoxin
Download Length: 158 a.a. Molecular weight: 17298.80 Da Isoelectric Point: 8.4143
>AT242614 WP_000287252.1 NZ_CP095843:3262354-3262827 [Escherichia fergusonii]
MYSPVQIANKFITLGNQHHNPLTHMQLQKLTYIAHGYYLALTGKPLLNECVSAWKYGPVIPGMYDAFKDYGNKPVTNVAV
APFGGIVTMDPQAESIIGAVYKFYGSKNGIELSTLTHMPGTPWSQAYNGIGSSIISNDAIKAYYHDLLNNRQQCQGL
MYSPVQIANKFITLGNQHHNPLTHMQLQKLTYIAHGYYLALTGKPLLNECVSAWKYGPVIPGMYDAFKDYGNKPVTNVAV
APFGGIVTMDPQAESIIGAVYKFYGSKNGIELSTLTHMPGTPWSQAYNGIGSSIISNDAIKAYYHDLLNNRQQCQGL
Download Length: 474 bp
>AT242614 NZ_OW849064:c1325725-1325474 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGACAAAGGAACGGAAAAGGAC
ATTATTGAGTGA
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGACAAAGGAACGGAAAAGGAC
ATTATTGAGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|