Detailed information of TA system TA242603

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 1766358..1767192
• Replicon: chromosome
• Accession: NZ_CP095843
• Organism: Escherichia fergusonii strain EF21QZZ116

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: -
• Locus tag: MYF53_RS08730
• Protein ID: WP_249896240.1
• Coordinates: 1766358..1766735 (-)
• Length: 126 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: A0A2X5LBZ2
• Locus tag: MYF53_RS08735
• Protein ID: WP_039025882.1
• Coordinates: 1766824..1767192 (-)
• Length: 123 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MYF53_RS08695 (1761420)	1761420..1761590	-	171	WP_000224914.1	NinE family protein	-
MYF53_RS08700 (1761590)	1761590..1761823	-	234	Protein_1710	DNA base-flipping protein YbcN	-
MYF53_RS08705 (1761913)	1761913..1763073	+	1161	WP_002432357.1	site-specific integrase	-
MYF53_RS08710 (1763299)	1763299..1764618	+	1320	WP_105284452.1	site-specific integrase	-
MYF53_RS08715 (1764711)	1764711..1765559	-	849	WP_039025884.1	DUF4942 domain-containing protein	-
MYF53_RS08720 (1765656)	1765656..1765853	-	198	WP_000772024.1	DUF957 domain-containing protein	-
MYF53_RS08725 (1765873)	1765873..1766361	-	489	Protein_1715	DUF5983 family protein	-
MYF53_RS08730 (1766358)	1766358..1766735	-	378	WP_249896240.1	type IV toxin-antitoxin system cytoskeleton-binding toxin CbtA	Toxin
MYF53_RS08735 (1766824)	1766824..1767192	-	369	WP_039025882.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
MYF53_RS08740 (1767242)	1767242..1767886	-	645	WP_039025881.1	hypothetical protein	-
MYF53_RS08745 (1767901)	1767901..1768122	-	222	WP_000692312.1	DUF987 domain-containing protein	-
MYF53_RS08750 (1768191)	1768191..1768667	-	477	WP_001186745.1	RadC family protein	-
MYF53_RS08755 (1768682)	1768682..1769167	-	486	WP_000214316.1	antirestriction protein	-
MYF53_RS08760 (1769258)	1769258..1770076	-	819	WP_001234702.1	DUF932 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-112)

Antitoxin

• Antitoxin CbeA (18-117)

Sequences

Toxin

Protein

• Length: 126 a.a.
• Molecular weight: 14234.26 Da
• Isoelectric Point: 7.1337

>T242603 WP_249896240.1 NZ_CP095843:c1766735-1766358 [Escherichia fergusonii]
MKTLPVLPGQAASSRPSPVEIWQTLLTRLLDQHYDLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQLEF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYQEAKR

Nucleotide

• Length: 378 bp

>T242603 NZ_OW848980:c4366473-4366300 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin

Protein

• Length: 123 a.a.
• Molecular weight: 13792.52 Da
• Isoelectric Point: 5.9582

>AT242603 WP_039025882.1 NZ_CP095843:c1767192-1766824 [Escherichia fergusonii]
VSDTFHETNYPDNNNDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPEMKN

Nucleotide

• Length: 369 bp

>AT242603 NZ_OW848980:c4366797-4366501 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTAATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTTAAATGCTTAGACTTACCGGATATT
GACTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Structures

Antitoxin

• AlphaFold DB: A0A2X5LBZ2