Detailed information of TA system TA242590

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 910913..912486
• Replicon: chromosome
• Accession: NZ_CP095841
• Organism: Aeromonas veronii strain AV040

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: MYF86_RS04365
• Protein ID: WP_247823714.1
• Coordinates: 911167..912486 (+)
• Length: 440 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: A0A3Q8DTG9
• Locus tag: MYF86_RS04360
• Protein ID: WP_042047685.1
• Coordinates: 910913..911167 (+)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MYF86_RS04335 (MYF86_04335)	906589..907404	+	816	WP_247823713.1	hypothetical protein	-
MYF86_RS04340 (MYF86_04340)	907450..907910	-	461	Protein_826	integrase core domain-containing protein	-
MYF86_RS04345 (MYF86_04345)	908804..909427	-	624	WP_042878565.1	recombinase family protein	-
MYF86_RS04350 (MYF86_04350)	909873..910322	+	450	WP_160836704.1	nucleotidyltransferase domain-containing protein	-
MYF86_RS04355 (MYF86_04355)	910315..910743	+	429	WP_042013332.1	DUF86 domain-containing protein	-
MYF86_RS04360 (MYF86_04360)	910913..911167	+	255	WP_042047685.1	helix-turn-helix domain-containing protein	Antitoxin
MYF86_RS04365 (MYF86_04365)	911167..912486	+	1320	WP_247823714.1	type II toxin-antitoxin system HipA family toxin	Toxin
MYF86_RS04370 (MYF86_04370)	912908..914890	-	1983	WP_247823715.1	Fe(3+)-hydroxamate ABC transporter permease FhuB	-
MYF86_RS04375 (MYF86_04375)	914887..915780	-	894	WP_247824158.1	ABC transporter substrate-binding protein	-
MYF86_RS04380 (MYF86_04380)	915811..916575	-	765	WP_247823716.1	ATP-binding cassette domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	895225..912486	17261

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (150-402)

Antitoxin

• Cro/C1-type helix-turn-helix domain (13-65)

Sequences

Toxin

Protein

• Length: 440 a.a.
• Molecular weight: 49429.44 Da
• Isoelectric Point: 7.2342

>T242590 WP_247823714.1 NZ_CP095841:911167-912486 [Aeromonas veronii]
MANLAVYMNGYRVGTFTKTTSGAHQFQYHESWLAQSGSRPISLSMPLRHQAYRGDEAYNFFDNLLPDNTEVRNRVVARYQ
AASTQPFDLLSCIGQDSVGALQLVTEGHDVPDVRRIDYKALSDDELEQILTSYKSGIPLGMVREQEEFRISIAGAQEKTA
LLYLDGRWYLPLNATPTTHIIKLPIGKIESHSYSIDLSQSVENEYLCTLIAKEFGLPVPHCFMMQVGQVKALAVERFDRR
YAADRSWIMRLPQEDFCQVLNVPSARKYESHGGPGITDIMKTLLGSATPEQDRYLFMKSQVLFWLLAATDGHAKNFSVFI
EPEGRFRLTPFYDILSVYPVFGGRGLNRRDAKLAMGLASSKGKKYAIEQIFPRHFFQTAKAVGFERSAMEEILTELANSV
DDVIERVTQQLPAGFPDAISSTILKGLKARSARLIKGWD

Nucleotide

• Length: 1320 bp

>T242590 NZ_OW848980:898831-899238 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9293.62 Da
• Isoelectric Point: 7.9834

>AT242590 WP_042047685.1 NZ_CP095841:910913-911167 [Aeromonas veronii]
MKVTSAKQLSACIKDARLSQKLSQGKVAEKVGIRQDTVSSFELNPESTKLETLFKILAALELSLDIKPRNESSDSPASGW
KEEW

Nucleotide

• Length: 255 bp

>AT242590 NZ_OW848980:898584-898850 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Structures

Antitoxin

• AlphaFold DB: A0A3Q8DTG9