Detailed information of TA system TA024258

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relE-Axe/YoeB-RelB
• Location: 4468761..4469205
• Replicon: chromosome
• Accession: NC_013216
• Organism: Desulfotomaculum acetoxidans DSM 771

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: DTOX_RS20745
• Protein ID: WP_015759637.1
• Coordinates: 4468761..4468958 (-)
• Length: 66 a.a.

Antitoxin (Protein)

• Gene name: Axe
• Uniprot ID: C8W000
• Locus tag: DTOX_RS20750
• Protein ID: WP_015759638.1
• Coordinates: 4468951..4469205 (-)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DTOX_RS20720	4464220..4464651	+	432	WP_015759633.1	C-GCAxxG-C-C family protein	-
DTOX_RS20725	4464840..4465355	+	516	WP_015759634.1	GNAT family N-acetyltransferase	-
DTOX_RS20730	4465443..4466759	+	1317	WP_042317561.1	glucosaminidase domain-containing protein	-
DTOX_RS20735	4466962..4468251	+	1290	WP_015759636.1	serpin family protein	-
DTOX_RS20745	4468761..4468958	-	198	WP_015759637.1	type II toxin-antitoxin system YoeB family toxin	Toxin
DTOX_RS20750	4468951..4469205	-	255	WP_015759638.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
DTOX_RS23335	4469576..4469716	-	141	WP_157863032.1	hypothetical protein	-
DTOX_RS20755	4469824..4470264	+	441	WP_052292986.1	tyrosine-type recombinase/integrase	-
DTOX_RS22610	4470421..4470888	-	468	WP_083773548.1	tRNA adenosine(34) deaminase TadA	-
DTOX_RS20765	4471227..4471790	+	564	WP_015759640.1	metal-dependent hydrolase	-
DTOX_RS20770	4471783..4472757	-	975	WP_015759641.1	UDP-glucose 4-epimerase GalE	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	4463625..4464029	404

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-39)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-70)

Sequences

Toxin

Protein

• Length: 66 a.a.
• Molecular weight: 7734.85 Da
• Isoelectric Point: 6.2529

>T24258 WP_015759637.1 NC_013216:c4468958-4468761 [Desulfofarcimen acetoxidans DSM 771]
MNKIWSDKSWDDYLSWQIQDKQILKRINELIKDIERNGLSKGILFDLTFQVNKIKGYSETTVTLD

Nucleotide

• Length: 198 bp

>T24258 NC_013216:c4468958-4468761 [Desulfofarcimen acetoxidans DSM 771]
ATGAATAAAATATGGTCAGACAAATCCTGGGATGATTATTTGTCGTGGCAGATTCAAGACAAACAGATACTCAAACGTAT
CAATGAGCTTATAAAAGATATTGAAAGAAATGGCTTGTCAAAAGGCATCCTTTTTGACCTAACTTTCCAGGTTAATAAAA
TCAAGGGTTACAGTGAAACTACTGTAACCCTTGATTGA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9669.00 Da
• Isoelectric Point: 4.5592

>AT24258 WP_015759638.1 NC_013216:c4469205-4468951 [Desulfofarcimen acetoxidans DSM 771]
MLAVNYSTIRNKLKEYCDRVTDERETVIVTRKDEKNVVIISLEEYNSMMKAAKNAEYLAMIDRSIEQLASGKGTVHELIE
VDDE

Nucleotide

• Length: 255 bp

>AT24258 NC_013216:c4469205-4468951 [Desulfofarcimen acetoxidans DSM 771]
ATGTTGGCAGTTAACTATTCGACAATACGTAATAAATTAAAAGAATATTGTGATCGTGTTACCGATGAGCGGGAAACAGT
AATTGTTACCCGGAAAGATGAGAAGAATGTCGTAATTATAAGCCTTGAGGAATATAATTCGATGATGAAGGCCGCAAAAA
ATGCAGAATACCTTGCAATGATTGATAGATCAATAGAACAGCTTGCATCAGGAAAAGGTACTGTGCATGAGCTCATTGAG
GTTGACGATGAATAA

Structures

Antitoxin

• AlphaFold DB: C8W000