Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-Axe/YoeB-RelB
Location 4468761..4469205 Replicon chromosome
Accession NC_013216
Organism Desulfotomaculum acetoxidans DSM 771

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag DTOX_RS20745 Protein ID WP_015759637.1
Coordinates 4468761..4468958 (-) Length 66 a.a.

Antitoxin (Protein)


Gene name Axe Uniprot ID C8W000
Locus tag DTOX_RS20750 Protein ID WP_015759638.1
Coordinates 4468951..4469205 (-) Length 85 a.a.

Genomic Context

DTOX_RS20720DTOX_RS20725DTOX_RS20730DTOX_RS20735DTOX_RS20755DTOX_RS20765DTOX_RS20745DTOX_RS20750DTOX_RS23335DTOX_RS22610DTOX_RS20770
Location: 4464220..4464651 (432 bp)
Type: Others
Protein ID: WP_015759633.1
Location: 4464840..4465355 (516 bp)
Type: Others
Protein ID: WP_015759634.1
Location: 4465443..4466759 (1317 bp)
Type: Others
Protein ID: WP_042317561.1
Location: 4466962..4468251 (1290 bp)
Type: Others
Protein ID: WP_015759636.1
Location: 4469824..4470264 (441 bp)
Type: Others
Protein ID: WP_052292986.1
Location: 4471227..4471790 (564 bp)
Type: Others
Protein ID: WP_015759640.1
Location: 4468761..4468958 (198 bp)
Type: Toxin
Protein ID: WP_015759637.1
Location: 4468951..4469205 (255 bp)
Type: Antitoxin
Protein ID: WP_015759638.1
Location: 4469576..4469716 (141 bp)
Type: Others
Protein ID: WP_157863032.1
Location: 4470421..4470888 (468 bp)
Type: Others
Protein ID: WP_083773548.1
Location: 4471783..4472757 (975 bp)
Type: Others
Protein ID: WP_015759641.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
DTOX_RS207204464220..4464651+432WP_015759633.1C-GCAxxG-C-C family protein-
DTOX_RS207254464840..4465355+516WP_015759634.1GNAT family N-acetyltransferase-
DTOX_RS207304465443..4466759+1317WP_042317561.1glucosaminidase domain-containing protein-
DTOX_RS207354466962..4468251+1290WP_015759636.1serpin family protein-
DTOX_RS207454468761..4468958-198WP_015759637.1type II toxin-antitoxin system YoeB family toxinToxin
DTOX_RS207504468951..4469205-255WP_015759638.1type II toxin-antitoxin system prevent-host-death family antitoxinAntitoxin
DTOX_RS233354469576..4469716-141WP_157863032.1hypothetical protein-
DTOX_RS207554469824..4470264+441WP_052292986.1tyrosine-type recombinase/integrase-
DTOX_RS226104470421..4470888-468WP_083773548.1tRNA adenosine(34) deaminase TadA-
DTOX_RS207654471227..4471790+564WP_015759640.1metal-dependent hydrolase-
DTOX_RS207704471783..4472757-975WP_015759641.1UDP-glucose 4-epimerase GalE-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-flankIS/Tn--4463625..4464029404


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-39)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-70)


Sequences

Toxin        


Download         Length: 66 a.a.        Molecular weight: 7734.85 Da        Isoelectric Point: 6.2529

>T24258 WP_015759637.1 NC_013216:c4468958-4468761 [Desulfofarcimen acetoxidans DSM 771]
MNKIWSDKSWDDYLSWQIQDKQILKRINELIKDIERNGLSKGILFDLTFQVNKIKGYSETTVTLD

Download         Length: 198 bp

>T24258 NC_013216:c4468958-4468761 [Desulfofarcimen acetoxidans DSM 771]
ATGAATAAAATATGGTCAGACAAATCCTGGGATGATTATTTGTCGTGGCAGATTCAAGACAAACAGATACTCAAACGTAT
CAATGAGCTTATAAAAGATATTGAAAGAAATGGCTTGTCAAAAGGCATCCTTTTTGACCTAACTTTCCAGGTTAATAAAA
TCAAGGGTTACAGTGAAACTACTGTAACCCTTGATTGA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9669.00 Da        Isoelectric Point: 4.5592

>AT24258 WP_015759638.1 NC_013216:c4469205-4468951 [Desulfofarcimen acetoxidans DSM 771]
MLAVNYSTIRNKLKEYCDRVTDERETVIVTRKDEKNVVIISLEEYNSMMKAAKNAEYLAMIDRSIEQLASGKGTVHELIE
VDDE

Download         Length: 255 bp

>AT24258 NC_013216:c4469205-4468951 [Desulfofarcimen acetoxidans DSM 771]
ATGTTGGCAGTTAACTATTCGACAATACGTAATAAATTAAAAGAATATTGTGATCGTGTTACCGATGAGCGGGAAACAGT
AATTGTTACCCGGAAAGATGAGAAGAATGTCGTAATTATAAGCCTTGAGGAATATAATTCGATGATGAAGGCCGCAAAAA
ATGCAGAATACCTTGCAATGATTGATAGATCAATAGAACAGCTTGCATCAGGAAAAGGTACTGTGCATGAGCTCATTGAG
GTTGACGATGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
AlphaFold DBC8W000

References