Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1533626..1534245 Replicon chromosome
Accession NZ_CP095786
Organism Escherichia fergusonii strain EF21JD053

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag MYB88_RS07380 Protein ID WP_001280991.1
Coordinates 1534027..1534245 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID -
Locus tag MYB88_RS07375 Protein ID WP_104917851.1
Coordinates 1533626..1534000 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MYB88_RS07365 (1528758) 1528758..1529951 + 1194 WP_002431407.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
MYB88_RS07370 (1529974) 1529974..1533123 + 3150 WP_223684912.1 efflux RND transporter permease AcrB -
MYB88_RS07375 (1533626) 1533626..1534000 + 375 WP_104917851.1 Hha toxicity modulator TomB Antitoxin
MYB88_RS07380 (1534027) 1534027..1534245 + 219 WP_001280991.1 HHA domain-containing protein Toxin
MYB88_RS07385 (1534742) 1534742..1535212 + 471 WP_002431406.1 YlaC family protein -
MYB88_RS07390 (1535351) 1535351..1536901 + 1551 WP_001260376.1 EAL domain-containing protein -
MYB88_RS07395 (1536943) 1536943..1537296 - 354 WP_000878140.1 DUF1428 domain-containing protein -
MYB88_RS07405 (1537675) 1537675..1537986 + 312 WP_000409907.1 MGMT family protein -
MYB88_RS07410 (1538017) 1538017..1538589 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T242564 WP_001280991.1 NZ_CP095786:1534027-1534245 [Escherichia fergusonii]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T242564 NZ_OW848785:3635238-3635522 [Escherichia coli]
ATGCAATTTACGGTATACCGCAGTCGCGGCAGGAACGCCGCGTTTCCCTTTGTTATTGATGTTACCAGCGACATTATTGG
TGAGATTAATCGCCGTATCGTTATTCCATTAACACCTATTGAACGATTTAGCCGTATTCGCCCACCAGAACGGCTTAACC
CAATCCTTTTACTGATAGACGGCAAAGAATATGTGCTCATGACGCATGAGACTGCAACTGTTCCAGTTAACGCGCTGGGA
ACGAAATTTTGCGATGCCAGCGCGCACCGAACGTTGATTAAATGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14511.31 Da        Isoelectric Point: 4.8989

>AT242564 WP_104917851.1 NZ_CP095786:1533626-1534000 [Escherichia fergusonii]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT242564 NZ_OW848785:3635002-3635235 [Escherichia coli]
ATGACTGCAAAACGTACCACACAAAGTGTGACCGTCACCGTCGACCGTGAGTTAGTCAATCGCGCTCGTGATGCAGGCTT
AAATATGAGCGCCACCCTTACGGTTGCGCTCAATGCTGAACTTAAAAAACATGCAGCAACACGTTGGCGTGAAGAGAACG
CAGAAGCTATCGCTGCGTTAAATCAATTGGCTGATGAAACCGGATGTTTCTCTGATGAGTACCGGAGCTTCTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure

References