Detailed information of TA system TA024256

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-DinJ
• Location: 1807527..1808073
• Replicon: chromosome
• Accession: NC_013216
• Organism: Desulfotomaculum acetoxidans DSM 771

Toxin (Protein)

• Gene name: relE
• Uniprot ID: C8VWZ4
• Locus tag: DTOX_RS08380
• Protein ID: WP_015757281.1
• Coordinates: 1807527..1807802 (-)
• Length: 92 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: C8VWZ5
• Locus tag: DTOX_RS08385
• Protein ID: WP_015757282.1
• Coordinates: 1807792..1808073 (-)
• Length: 94 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DTOX_RS08360	1802536..1805139	+	2604	WP_015757277.1	bifunctional acetaldehyde-CoA/alcohol dehydrogenase	-
DTOX_RS08365	1805163..1805555	+	393	WP_015757278.1	hypothetical protein	-
DTOX_RS08370	1805891..1807129	+	1239	WP_015757279.1	hypothetical protein	-
DTOX_RS08375	1807189..1807428	+	240	WP_157862881.1	hypothetical protein	-
DTOX_RS08380	1807527..1807802	-	276	WP_015757281.1	type II toxin-antitoxin system YafQ family toxin	Toxin
DTOX_RS08385	1807792..1808073	-	282	WP_015757282.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
DTOX_RS08390	1808330..1808620	-	291	WP_015757283.1	hypothetical protein	-
DTOX_RS08395	1809700..1811856	+	2157	WP_015757284.1	DUF3160 domain-containing protein	-
DTOX_RS21400	1811867..1812763	+	897	WP_052292919.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (3-91)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (7-69)

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 10534.30 Da
• Isoelectric Point: 8.9008

>T24256 WP_015757281.1 NC_013216:c1807802-1807527 [Desulfofarcimen acetoxidans DSM 771]
MKYEILSTGRFKKDLKTIMKRGYNIQLLQDVVSLLAAGIPLPEKNKDHMLTGYWTGHRECHITSDWLLIYKIDNDVLVLT
LTRTGTHSDLF

Nucleotide

• Length: 276 bp

>T24256 NC_013216:c1807802-1807527 [Desulfofarcimen acetoxidans DSM 771]
ATGAAGTATGAGATTTTATCGACAGGTAGATTCAAAAAAGACTTAAAGACAATTATGAAGCGAGGGTATAATATCCAATT
GCTGCAAGATGTTGTTTCTCTGTTGGCGGCTGGAATCCCCTTGCCGGAGAAAAACAAAGACCATATGTTAACAGGTTATT
GGACCGGACATAGAGAATGCCATATTACTTCCGACTGGCTTTTGATTTACAAGATTGACAACGATGTTTTAGTTTTGACA
CTTACCAGAACAGGCACACACAGCGACTTATTTTGA

Antitoxin

Protein

• Length: 94 a.a.
• Molecular weight: 10622.06 Da
• Isoelectric Point: 4.6662

>AT24256 WP_015757282.1 NC_013216:c1808073-1807792 [Desulfofarcimen acetoxidans DSM 771]
MSETTNLTIRINKELKEQAEQLFSELGMNMTTAFTVFVRQAVRQGKIPFEISLNIPNAETIAAMEEANRISRDPNAKRYS
SFEELIAEVRNEV

Nucleotide

• Length: 282 bp

>AT24256 NC_013216:c1808073-1807792 [Desulfofarcimen acetoxidans DSM 771]
ATGTCTGAAACAACAAATTTAACCATTCGCATTAATAAAGAACTCAAAGAACAGGCAGAACAACTTTTCTCTGAATTGGG
TATGAATATGACGACAGCATTCACTGTTTTCGTCCGACAGGCTGTTCGGCAGGGAAAAATACCCTTTGAAATTTCTTTAA
ATATTCCGAATGCTGAAACAATAGCGGCTATGGAAGAAGCCAATAGAATAAGCCGTGACCCAAATGCAAAACGCTATTCA
AGTTTTGAAGAACTGATAGCGGAGGTCCGGAATGAAGTATGA

Structures

Toxin

• AlphaFold DB: C8VWZ4

Antitoxin

• AlphaFold DB: C8VWZ5