Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4265629..4266286 Replicon chromosome
Accession NZ_CP095776
Organism Klebsiella pneumoniae strain bo714

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag MX575_RS20990 Protein ID WP_002916310.1
Coordinates 4265629..4266039 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag MX575_RS20995 Protein ID WP_002916312.1
Coordinates 4266020..4266286 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MX575_RS20970 (MX575_20970) 4261629..4263362 - 1734 WP_004151783.1 single-stranded-DNA-specific exonuclease RecJ -
MX575_RS20975 (MX575_20975) 4263368..4264081 - 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
MX575_RS20980 (MX575_20980) 4264104..4265000 - 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
MX575_RS20985 (MX575_20985) 4265101..4265622 + 522 WP_002916308.1 flavodoxin FldB -
MX575_RS20990 (MX575_20990) 4265629..4266039 - 411 WP_002916310.1 protein YgfX Toxin
MX575_RS20995 (MX575_20995) 4266020..4266286 - 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
MX575_RS21000 (MX575_21000) 4266532..4267515 + 984 WP_002916313.1 tRNA-modifying protein YgfZ -
MX575_RS21005 (MX575_21005) 4267666..4268325 - 660 WP_002916317.1 hemolysin III family protein -
MX575_RS21010 (MX575_21010) 4268489..4268800 - 312 WP_002916319.1 N(4)-acetylcytidine aminohydrolase -
MX575_RS21015 (MX575_21015) 4268850..4269578 + 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
MX575_RS21020 (MX575_21020) 4269697..4271130 + 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T242545 WP_002916310.1 NZ_CP095776:c4266039-4265629 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T242545 NZ_OW724079:c1076874-1076620 [Streptococcus sp. Marseille-Q3533]
ATGCTACTCAAGTTTACAGAAGATGCCTGGGCAGATTATTGCTATTGGCAAAACCAAGATAAGAAAACATTAAAAAGAAT
CAACAAACTAATCAAGGATATTCAACGTGATCCATTTACAGGAATTGGTAAACCAGAACCACTCAAATATGATTACCAAG
GAGCGTGGTCACGTCGTATTGATGCAGAGAATCGCATCATCTATATGATGGATGGTGATAGCGTCGCTTTCTTATCCTTT
AAGGATCATTACTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT242545 WP_002916312.1 NZ_CP095776:c4266286-4266020 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT242545 NZ_OW724079:c1077132-1076878 [Streptococcus sp. Marseille-Q3533]
ATGGAAGCAGTTCTTTACTCAACATTCCGAAATCATTTAAAAGACTACATGAAGAAGGTAAACGATGAATTTGAACCTTT
GACAGTTGTCAACAAAAATCCAGACGAGGACATTGTAGTCCTTTCAAAGAGCGAGTGGAATAGTATTCAAGAAACCTTGA
GAATTGCTCAGAACAAGGAGCTTTCTGACAAGGTATTGCGAGGAATATCCCAAGTTCGTGCGGGACACACTCAGGTGCAT
GTGATTGAGGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References