242544

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2974541..2976129 Replicon chromosome
Accession NZ_CP095776
Organism Klebsiella pneumoniae strain bo714

Toxin (Protein)


Gene name hipA Uniprot ID W8UI36
Locus tag MX575_RS14620 Protein ID WP_002904792.1
Coordinates 2974541..2975863 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0H3GXD8
Locus tag MX575_RS14625 Protein ID WP_002904790.1
Coordinates 2975863..2976129 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MX575_RS14605 (MX575_14605) 2969597..2972098 + 2502 WP_004151634.1 fimbria/pilus outer membrane usher protein -
MX575_RS14610 (MX575_14610) 2972086..2973090 + 1005 WP_002904798.1 fimbrial protein -
MX575_RS14615 (MX575_14615) 2973232..2974524 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
MX575_RS14620 (MX575_14620) 2974541..2975863 - 1323 WP_002904792.1 type II toxin-antitoxin system HipA family toxin Toxin
MX575_RS14625 (MX575_14625) 2975863..2976129 - 267 WP_002904790.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
MX575_RS14630 (MX575_14630) 2976395..2976721 - 327 WP_002904788.1 hydroxyisourate hydrolase -
MX575_RS14635 (MX575_14635) 2976718..2977218 - 501 WP_002904787.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
MX575_RS14640 (MX575_14640) 2977196..2978575 - 1380 WP_002904785.1 nucleobase:cation symporter-2 family protein -
MX575_RS14645 (MX575_14645) 2978921..2980075 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
MX575_RS14650 (MX575_14650) 2980056..2980979 - 924 WP_002904781.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49171.46 Da        Isoelectric Point: 7.5357

>T242544 WP_002904792.1 NZ_CP095776:c2975863-2974541 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

>T242544 NZ_OW707734:c3765742-3765640 [Salmonella enterica subsp. enterica serovar Typhi]
GCAAGGCGATTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9906.27 Da        Isoelectric Point: 8.5912

>AT242544 WP_002904790.1 NZ_CP095776:c2976129-2975863 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp

>AT242544 NZ_OW707734:3765638-3765781 [Salmonella enterica subsp. enterica serovar Typhi]
ATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTAATGCAGGCTAAATCGCCTTGCTCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E1CEC8

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GXD8

References