242532

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tad-ata/COG5606-COG4679
Location 29066..29759 Replicon plasmid p34Pae8-KPC
Accession NZ_CP095775
Organism Pseudomonas aeruginosa strain 34Pae8

Toxin (Protein)


Gene name tad Uniprot ID N2IHR9
Locus tag MX625_RS32290 Protein ID WP_003151133.1
Coordinates 29382..29759 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name ata Uniprot ID N2IIN5
Locus tag MX625_RS32285 Protein ID WP_001172026.1
Coordinates 29066..29401 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MX625_RS32260 24952..26418 + 1467 WP_229602014.1 MobF family relaxase -
MX625_RS32265 26545..27832 - 1288 Protein_35 HD-GYP domain-containing protein -
MX625_RS32270 27989..28369 - 381 WP_001054412.1 hypothetical protein -
MX625_RS32275 28366..28692 - 327 WP_000091614.1 hypothetical protein -
MX625_RS32280 28716..29051 - 336 WP_000741275.1 hypothetical protein -
MX625_RS32285 29066..29401 - 336 WP_001172026.1 helix-turn-helix transcriptional regulator Antitoxin
MX625_RS32290 29382..29759 - 378 WP_003151133.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MX625_RS32295 29866..29931 + 66 Protein_41 hypothetical protein -
MX625_RS32300 30006..31688 + 1683 WP_171886487.1 DDE-type integrase/transposase/recombinase -
MX625_RS32305 31691..32599 + 909 WP_011494285.1 TniB family NTP-binding protein -
MX625_RS32310 32596..33813 + 1218 WP_009288528.1 TniQ family protein -
MX625_RS32315 33875..34498 + 624 WP_003155741.1 recombinase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid blaKPC-2 / aac(6')-29b / aac(3)-Id - 1..42729 42729


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(16-109)

Antitoxin

Cro/C1-type helix-turn-helix domain

(40-93)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 13705.78 Da        Isoelectric Point: 9.4693

>T242532 WP_003151133.1 NZ_CP095775:c29759-29382 [Pseudomonas aeruginosa]
MTNKEKPLEWIASSHKDLMALPSDVRRRFGYALSLAQIGDQDDAAKVLKGFGGAGVLEVVEDDAGGTYRAVYTVKFAEAV
FVLHCFQKKSKSGIATPKADMDIIRARLKVAEVLAQELRNAKTNH

Download         Length: 378 bp

>T242532 NZ_OW706648:4667158-4667445 [Salmonella enterica subsp. enterica serovar Typhi]
ATGCCGATGGAGTTTGAATGGGATGCGAACAAGGCTAAAAGCAACCTGAGGAAGCACGGTGTCCGCTTTGAGGATGCGGT
ACTGGTGTTTGACGATCCCCGACACCTGTCACGTCAGGAGCGTTATGAGAATGGAGAATATCGTTGGCAGACCCTCGGCC
TTGTTCATGGCATTGTGGTCATTCTGGTTGCTCATAGCGTTCGGTTCGAAAGTGGTTTTGAAGTTATCCGTATCATCAGC
GCTCGTAAGGCAGACAGAAAAGAGAGGAATCGTTATGAGCATGGTTAA

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12201.39 Da        Isoelectric Point: 10.6058

>AT242532 WP_001172026.1 NZ_CP095775:c29401-29066 [Pseudomonas aeruginosa]
MQKRIIEGVEVQRSSGNVFADLGLPDAEKLKIKTGLVVEIRRAMRALGLTQQAAAKRMGIPQPKVSGMMRGDFTNLSERK
LMDCLNRLGYDIEIKVRPAAEPIGHLTLATA

Download         Length: 336 bp

>AT242532 NZ_OW706648:4667432-4667734 [Salmonella enterica subsp. enterica serovar Typhi]
ATGAGCATGGTTAAACATAAACGCGGCAACGCATCCGCGCTGAGTGCTCAGCATGAGGCTGAACTGAAGGCGCTGGCGAA
AAAATCAGATGATGAGATTGATTACAGCGACATTCCCGCTTCGGAGGATGGACAGTGGTCTGAAGCAGTGCGTGGTAAGT
TTTTTCGCCCGTTAAAAACTCAGGCCTCGGTGCGTATTGACGCCGACGTTATGGAATGGCTGAAACGGCCAGGAAAAGGC
TACCAGACGCGGCTGAATGCCATTCTGCGCGAAGCGATGCTGCGCGAGCAAAATAAGAAATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A024ELN5

Antitoxin

Source ID Structure
AlphaFold DB A0A024EKI7

References