Detailed information of TA system TA242529

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/-
• Location: 2824272..2825493
• Replicon: chromosome
• Accession: NZ_CP095774
• Organism: Pseudomonas aeruginosa strain 34Pae8

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: V6AG16
• Locus tag: MX625_RS13430
• Protein ID: WP_003088107.1
• Coordinates: 2824272..2824850 (-)
• Length: 193 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: MX625_RS13435
• Protein ID: WP_003088112.1
• Coordinates: 2824939..2825493 (-)
• Length: 185 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MX625_RS13415	2819548..2820825	+	1278	WP_003088104.1	TolC family protein	-
MX625_RS13420	2820815..2822986	+	2172	WP_003088105.1	type I secretion system permease/ATPase	-
MX625_RS13425	2822976..2824163	+	1188	WP_003088106.1	HlyD family efflux transporter periplasmic adaptor subunit	-
MX625_RS13430	2824272..2824850	-	579	WP_003088107.1	HD domain-containing protein	Toxin
MX625_RS13435	2824939..2825493	-	555	WP_003088112.1	helix-turn-helix transcriptional regulator	Antitoxin
MX625_RS13440	2825651..2827846	-	2196	WP_003088114.1	xanthine dehydrogenase family protein molybdopterin-binding subunit	-
MX625_RS13445	2827851..2828312	-	462	WP_003088117.1	(2Fe-2S)-binding protein	-
MX625_RS13450	2828643..2828966	+	324	WP_003102734.1	multidrug efflux SMR transporter	-
MX625_RS13455	2828979..2829377	+	399	WP_003088123.1	NADH-quinone oxidoreductase subunit A	-
MX625_RS13460	2829374..2829925	-	552	WP_023098678.1	XRE family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• 5'-deoxynucleotidase YfbR/HDDC2 (7-187)

Antitoxin

• Cro/C1-type helix-turn-helix domain (14-62)

Sequences

Toxin

Protein

• Length: 193 a.a.
• Molecular weight: 21885.74 Da
• Isoelectric Point: 5.3655

>T242529 WP_003088107.1 NZ_CP095774:c2824850-2824272 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDTPLRDRLLALWDEYERGETAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDAKTRQRLAARRDA

Nucleotide

• Length: 579 bp

>T242529 NZ_OW706648:4326202-4326693 [Salmonella enterica subsp. enterica serovar Typhi]
ATGATCTCCACCCCTGAGCCGCTTCATGCCGGACATATTCTTACTCCGTTTTGCTGCGGTGTGGATTCTATAGATAACTG
GCTGAAACAGCGGGCGATGAAAAATCAGACCACTGGCGCGTCCCGTACCTTTGTGTGTTGTGGCAGCGATTCGAACGTAC
TGGCCTATTACTCGCTGGCGTCCAGCGCGGTCACGACGAATACCTCCCCCGGTCGCTTTCGTCGCAATATGCCTGACCCG
ATTCCGGTTGTGGTATTGGGGCGTCTGGCGGTGGATAAATCGCTTCATGGGCAGGGCGTCGCTCGGGCGCTGGTACGCGA
CGCAGGGCTGCGGGTTATTCAGGTGGCGGAGACTATCGGCATTCGTGGGATGCTGGTTCACGCCCTGTCGGATGAAGCGC
GGGAATTTTATCAGTGGGTGGGGTTTGTACCGTCGCCGATGGATCCGATGATGTTGATGGTGACGTTGGGGGATTTGGTG
GAGAGTGTTTAA

Antitoxin

Protein

• Length: 185 a.a.
• Molecular weight: 20454.63 Da
• Isoelectric Point: 8.1590

>AT242529 WP_003088112.1 NZ_CP095774:c2825493-2824939 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Nucleotide

• Length: 555 bp

>AT242529 NZ_OW706648:4325912-4326205 [Salmonella enterica subsp. enterica serovar Typhi]
ATGCCAGCCGCAAACAGTATGGCGATGAAACGTGAAACTCTGAACCTGCGTATCAAACCCGCCGAGCGCGATCTTATTGA
TCGAGCGGCGAAAGCCAGAGGGAAAAACCGCACAGACTTTGTGTTGGAAGCTGCCCGTGCTGCCGCAGAAGAAGTGCTTA
TCGAACAACGCATCATTATGGCCGATCCAGAGGCTTATCAGGAATTTCTCGTTCGTTTGGATCAAACACCTTCACCTAAT
GCCGCACTGCGTAAAACCATGCAGACCCCTGCGCCGTGGGAGCAGGAAAAATGA

Structures

Toxin

• AlphaFold DB: V6AG16