Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 1388425..1388998 Replicon chromosome
Accession NZ_CP095774
Organism Pseudomonas aeruginosa strain 34Pae8

Toxin (Protein)


Gene name relE Uniprot ID W5IUR0
Locus tag MX625_RS06510 Protein ID WP_009618209.1
Coordinates 1388711..1388998 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID W5ISI7
Locus tag MX625_RS06505 Protein ID WP_009618210.1
Coordinates 1388425..1388724 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MX625_RS06475 1383527..1383745 + 219 WP_011829925.1 AlpA family transcriptional regulator -
MX625_RS06480 1383786..1384652 + 867 WP_018076212.1 ParA family protein -
MX625_RS06485 1384636..1384872 + 237 WP_013982111.1 type II toxin-antitoxin system HicA family toxin -
MX625_RS06490 1384865..1386523 + 1659 WP_018076213.1 ParB family protein -
MX625_RS06495 1386541..1387101 + 561 WP_018076214.1 DUF2857 domain-containing protein -
MX625_RS06500 1387104..1388297 + 1194 WP_017244810.1 STY4528 family pathogenicity island replication protein -
MX625_RS06505 1388425..1388724 + 300 WP_009618210.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
MX625_RS06510 1388711..1388998 + 288 WP_009618209.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MX625_RS06515 1389027..1389218 + 192 WP_011805449.1 hypothetical protein -
MX625_RS06520 1389342..1390121 + 780 WP_017244811.1 TIGR03761 family integrating conjugative element protein -
MX625_RS06525 1390118..1390666 + 549 WP_017244812.1 DUF3158 family protein -
MX625_RS06530 1390663..1391046 + 384 WP_016852001.1 single-stranded DNA-binding protein -
MX625_RS06535 1391341..1393356 + 2016 WP_043221507.1 DNA topoisomerase III -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 1379136..1467524 88388


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-90)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-58)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10854.46 Da        Isoelectric Point: 8.4628

>T242527 WP_009618209.1 NZ_CP095774:1388711-1388998 [Pseudomonas aeruginosa]
VRVLEWREAARADLLAIVDYISDDNPDAAQRLKDDIEAKAAKLPERPKLYRPGRVAGTREMVVRANYVVVYMEDTRAVSI
LRVLHAAQQWPPARE

Download         Length: 288 bp

>T242527 NZ_OW706648:3624827-3625138 [Salmonella enterica subsp. enterica serovar Typhi]
GTGCATGTTATCAGCCGAAAACTGTTCAATGAAGCGATGCTCATGTATCCAAACCATGAGCTTGCTCTCACTGAGTTGCT
GAATGTTCTGGAGAAAAAAACATTCACTCAGCCTGAAGAGATGAAGCGGTATATTCCTTCGCTGGATAATTTTAAGTACA
GAGATAAATGGTGGGTGATTGATGTTTCTGGTAACAGCCTGAGACTCATTTCCTACATAGATTTCAGGTTACATAAGATA
TTTGTGAAACATATCGTTTCCCATGCCGAATATGACAAACTGACCGCATATTATCGGGGTAATGAAGAATGA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10816.46 Da        Isoelectric Point: 8.6579

>AT242527 WP_009618210.1 NZ_CP095774:1388425-1388724 [Pseudomonas aeruginosa]
MAAQTSMLHIRVDDKLKADAAEKLAGVGLTVSDAVRILLTRVVKEGALPAGLTADPEAYDAWFRAKVQEALADTRPPVPH
QQVMDEAQALIDRKRRART

Download         Length: 300 bp

>AT242527 NZ_OW706648:3625135-3625581 [Salmonella enterica subsp. enterica serovar Typhi]
ATGAGAACTCATCGTCAGATGGATGCAACCAGCGCAAAAAAGATCGTTGATACCTTCAGCGATGCGGTAAAAAGCGTCCC
ACTGATGGGGGAAGACCGAAATGACAATGAGTATCGCAGGGCACTAGCGCTAGTGGAGTTTCTGGTCGACCACGACGATC
TTGAAAACCCACTATTTGAATTGCTCTGTGCCCGAATCAGTGAATACGAAAAACATGCGCCGGAATTCAAAGCACTCAAC
CAACACCTGGAGAAAACGCCCCCTGGCGTTTCAGTATTGCGAACGCTCATGGATCAATACGGTCTCAAAGCAGCAGATCT
TGCCAACGAACTTGGTTCTAAATCGAACGTCAGCAACATCTTAAATGGCCGCAGAGCACTAACGGTTAATCATATTAAAG
CGCTTACACAACGCTTTAAACTACCAGCGGATGCCTTCATCGAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5R9QF16

Antitoxin

Source ID Structure
AlphaFold DB A0A5R9QE11

References