Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/RelE-RelB |
| Location | 1388425..1388998 | Replicon | chromosome |
| Accession | NZ_CP095774 | ||
| Organism | Pseudomonas aeruginosa strain 34Pae8 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | W5IUR0 |
| Locus tag | MX625_RS06510 | Protein ID | WP_009618209.1 |
| Coordinates | 1388711..1388998 (+) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | W5ISI7 |
| Locus tag | MX625_RS06505 | Protein ID | WP_009618210.1 |
| Coordinates | 1388425..1388724 (+) | Length | 100 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MX625_RS06475 | 1383527..1383745 | + | 219 | WP_011829925.1 | AlpA family transcriptional regulator | - |
| MX625_RS06480 | 1383786..1384652 | + | 867 | WP_018076212.1 | ParA family protein | - |
| MX625_RS06485 | 1384636..1384872 | + | 237 | WP_013982111.1 | type II toxin-antitoxin system HicA family toxin | - |
| MX625_RS06490 | 1384865..1386523 | + | 1659 | WP_018076213.1 | ParB family protein | - |
| MX625_RS06495 | 1386541..1387101 | + | 561 | WP_018076214.1 | DUF2857 domain-containing protein | - |
| MX625_RS06500 | 1387104..1388297 | + | 1194 | WP_017244810.1 | STY4528 family pathogenicity island replication protein | - |
| MX625_RS06505 | 1388425..1388724 | + | 300 | WP_009618210.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | Antitoxin |
| MX625_RS06510 | 1388711..1388998 | + | 288 | WP_009618209.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| MX625_RS06515 | 1389027..1389218 | + | 192 | WP_011805449.1 | hypothetical protein | - |
| MX625_RS06520 | 1389342..1390121 | + | 780 | WP_017244811.1 | TIGR03761 family integrating conjugative element protein | - |
| MX625_RS06525 | 1390118..1390666 | + | 549 | WP_017244812.1 | DUF3158 family protein | - |
| MX625_RS06530 | 1390663..1391046 | + | 384 | WP_016852001.1 | single-stranded DNA-binding protein | - |
| MX625_RS06535 | 1391341..1393356 | + | 2016 | WP_043221507.1 | DNA topoisomerase III | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integrative and Conjugative Element | - | - | 1379136..1467524 | 88388 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 10854.46 Da Isoelectric Point: 8.4628
>T242527 WP_009618209.1 NZ_CP095774:1388711-1388998 [Pseudomonas aeruginosa]
VRVLEWREAARADLLAIVDYISDDNPDAAQRLKDDIEAKAAKLPERPKLYRPGRVAGTREMVVRANYVVVYMEDTRAVSI
LRVLHAAQQWPPARE
VRVLEWREAARADLLAIVDYISDDNPDAAQRLKDDIEAKAAKLPERPKLYRPGRVAGTREMVVRANYVVVYMEDTRAVSI
LRVLHAAQQWPPARE
Download Length: 288 bp
>T242527 NZ_OW706648:3624827-3625138 [Salmonella enterica subsp. enterica serovar Typhi]
GTGCATGTTATCAGCCGAAAACTGTTCAATGAAGCGATGCTCATGTATCCAAACCATGAGCTTGCTCTCACTGAGTTGCT
GAATGTTCTGGAGAAAAAAACATTCACTCAGCCTGAAGAGATGAAGCGGTATATTCCTTCGCTGGATAATTTTAAGTACA
GAGATAAATGGTGGGTGATTGATGTTTCTGGTAACAGCCTGAGACTCATTTCCTACATAGATTTCAGGTTACATAAGATA
TTTGTGAAACATATCGTTTCCCATGCCGAATATGACAAACTGACCGCATATTATCGGGGTAATGAAGAATGA
GTGCATGTTATCAGCCGAAAACTGTTCAATGAAGCGATGCTCATGTATCCAAACCATGAGCTTGCTCTCACTGAGTTGCT
GAATGTTCTGGAGAAAAAAACATTCACTCAGCCTGAAGAGATGAAGCGGTATATTCCTTCGCTGGATAATTTTAAGTACA
GAGATAAATGGTGGGTGATTGATGTTTCTGGTAACAGCCTGAGACTCATTTCCTACATAGATTTCAGGTTACATAAGATA
TTTGTGAAACATATCGTTTCCCATGCCGAATATGACAAACTGACCGCATATTATCGGGGTAATGAAGAATGA
Antitoxin
Download Length: 100 a.a. Molecular weight: 10816.46 Da Isoelectric Point: 8.6579
>AT242527 WP_009618210.1 NZ_CP095774:1388425-1388724 [Pseudomonas aeruginosa]
MAAQTSMLHIRVDDKLKADAAEKLAGVGLTVSDAVRILLTRVVKEGALPAGLTADPEAYDAWFRAKVQEALADTRPPVPH
QQVMDEAQALIDRKRRART
MAAQTSMLHIRVDDKLKADAAEKLAGVGLTVSDAVRILLTRVVKEGALPAGLTADPEAYDAWFRAKVQEALADTRPPVPH
QQVMDEAQALIDRKRRART
Download Length: 300 bp
>AT242527 NZ_OW706648:3625135-3625581 [Salmonella enterica subsp. enterica serovar Typhi]
ATGAGAACTCATCGTCAGATGGATGCAACCAGCGCAAAAAAGATCGTTGATACCTTCAGCGATGCGGTAAAAAGCGTCCC
ACTGATGGGGGAAGACCGAAATGACAATGAGTATCGCAGGGCACTAGCGCTAGTGGAGTTTCTGGTCGACCACGACGATC
TTGAAAACCCACTATTTGAATTGCTCTGTGCCCGAATCAGTGAATACGAAAAACATGCGCCGGAATTCAAAGCACTCAAC
CAACACCTGGAGAAAACGCCCCCTGGCGTTTCAGTATTGCGAACGCTCATGGATCAATACGGTCTCAAAGCAGCAGATCT
TGCCAACGAACTTGGTTCTAAATCGAACGTCAGCAACATCTTAAATGGCCGCAGAGCACTAACGGTTAATCATATTAAAG
CGCTTACACAACGCTTTAAACTACCAGCGGATGCCTTCATCGAGTAG
ATGAGAACTCATCGTCAGATGGATGCAACCAGCGCAAAAAAGATCGTTGATACCTTCAGCGATGCGGTAAAAAGCGTCCC
ACTGATGGGGGAAGACCGAAATGACAATGAGTATCGCAGGGCACTAGCGCTAGTGGAGTTTCTGGTCGACCACGACGATC
TTGAAAACCCACTATTTGAATTGCTCTGTGCCCGAATCAGTGAATACGAAAAACATGCGCCGGAATTCAAAGCACTCAAC
CAACACCTGGAGAAAACGCCCCCTGGCGTTTCAGTATTGCGAACGCTCATGGATCAATACGGTCTCAAAGCAGCAGATCT
TGCCAACGAACTTGGTTCTAAATCGAACGTCAGCAACATCTTAAATGGCCGCAGAGCACTAACGGTTAATCATATTAAAG
CGCTTACACAACGCTTTAAACTACCAGCGGATGCCTTCATCGAGTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A5R9QF16 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A5R9QE11 |