242524

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 147376..147881 Replicon chromosome
Accession NZ_CP095774
Organism Pseudomonas aeruginosa strain 34Pae8

Toxin (Protein)


Gene name parE Uniprot ID V6A7K8
Locus tag MX625_RS00660 Protein ID WP_003083773.1
Coordinates 147376..147657 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1C7BDS9
Locus tag MX625_RS00665 Protein ID WP_003083775.1
Coordinates 147654..147881 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MX625_RS00635 142627..143976 + 1350 WP_003137006.1 C4-dicarboxylate transporter DctA -
MX625_RS00640 144025..144711 + 687 WP_003083762.1 FadR/GntR family transcriptional regulator -
MX625_RS00645 144812..145546 + 735 WP_003083764.1 GntR family transcriptional regulator -
MX625_RS00650 145726..146136 + 411 WP_003110659.1 aegerolysin family protein -
MX625_RS00655 146168..147076 - 909 WP_003083769.1 LysR family transcriptional regulator -
MX625_RS00660 147376..147657 - 282 WP_003083773.1 type II toxin-antitoxin system toxin ParE Toxin
MX625_RS00665 147654..147881 - 228 WP_003083775.1 CopG family ribbon-helix-helix protein Antitoxin
MX625_RS00670 148057..148677 - 621 WP_003101226.1 hypothetical protein -
MX625_RS00675 148778..149278 + 501 WP_003083778.1 LEA type 2 family protein -
MX625_RS00680 149351..149692 + 342 WP_014603467.1 zinc ribbon domain-containing protein YjdM -
MX625_RS00685 149774..151201 - 1428 WP_003083784.1 GABA permease -
MX625_RS00690 151370..152863 - 1494 WP_003083788.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10462.19 Da        Isoelectric Point: 10.0435

>T242524 WP_003083773.1 NZ_CP095774:c147657-147376 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

>T242524 NZ_OW706648:c2971947-2971549 [Salmonella enterica subsp. enterica serovar Typhi]
ATGCTGAAATTCATGCTTGATACCAATACTTGTATTTTCACCATCAAAAATAAGCCCGAACACATCAGAGAACGCTTCAA
CCTCAATACATCCCGAATGTGTATCAGCTCCATCACCTTAATGGAGCTGATTTACGGTGCTGAAAAAAGCCTGGCACCGG
AGCGTAATTTTGCAGTCGTGGAGGGATTTATCTCCCGCCTTGAGGTTCTGGATTACGATACACAGGCAGCGATACATACC
GGTCAAATCCGTACCGAACTGGCCCGCAAGGGAACACCTGTCGGGTCTTATGACCAGATGATTGCTGGCCATGCCCGTAG
CCGCGGACTGGTCGTCGTCACAAACAATCTCCGCGAGTTTGAACGCATTCCGGGTATCCGAATCGAAGACTGGTGCTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8556.58 Da        Isoelectric Point: 5.5740

>AT242524 WP_003083775.1 NZ_CP095774:c147881-147654 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Download         Length: 228 bp

>AT242524 NZ_OW706648:c2972174-2971947 [Salmonella enterica subsp. enterica serovar Typhi]
ATGCACACAACACTTTTTTTTAGTAACCGGACCCAGGCAGTCAGATTGCCTAAATCGATATCCTTTCCGGAGGATGTGAA
ACATGTCGAAATCATTGCGGTTGGTAGAAGCAGAATCATTACTCCAGTCGGAGAATCCTGGGACAGCTGGTTCGATGGCG
AAGGCGCCAGTACTGATTTTATGAGCACCAGAGAACAACCCGCAGTACAGGAACGGGAAGGATTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6XRW

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7BDS9

References