Detailed information of TA system TA242524

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RHH(antitoxin)
• Location: 147376..147881
• Replicon: chromosome
• Accession: NZ_CP095774
• Organism: Pseudomonas aeruginosa strain 34Pae8

Toxin (Protein)

• Gene name: parE
• Uniprot ID: V6A7K8
• Locus tag: MX625_RS00660
• Protein ID: WP_003083773.1
• Coordinates: 147376..147657 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: A0A1C7BDS9
• Locus tag: MX625_RS00665
• Protein ID: WP_003083775.1
• Coordinates: 147654..147881 (-)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MX625_RS00635	142627..143976	+	1350	WP_003137006.1	C4-dicarboxylate transporter DctA	-
MX625_RS00640	144025..144711	+	687	WP_003083762.1	FadR/GntR family transcriptional regulator	-
MX625_RS00645	144812..145546	+	735	WP_003083764.1	GntR family transcriptional regulator	-
MX625_RS00650	145726..146136	+	411	WP_003110659.1	aegerolysin family protein	-
MX625_RS00655	146168..147076	-	909	WP_003083769.1	LysR family transcriptional regulator	-
MX625_RS00660	147376..147657	-	282	WP_003083773.1	type II toxin-antitoxin system toxin ParE	Toxin
MX625_RS00665	147654..147881	-	228	WP_003083775.1	CopG family ribbon-helix-helix protein	Antitoxin
MX625_RS00670	148057..148677	-	621	WP_003101226.1	hypothetical protein	-
MX625_RS00675	148778..149278	+	501	WP_003083778.1	LEA type 2 family protein	-
MX625_RS00680	149351..149692	+	342	WP_014603467.1	zinc ribbon domain-containing protein YjdM	-
MX625_RS00685	149774..151201	-	1428	WP_003083784.1	GABA permease	-
MX625_RS00690	151370..152863	-	1494	WP_003083788.1	CoA-acylating methylmalonate-semialdehyde dehydrogenase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-87)

Antitoxin

• Ribbon-helix-helix protein, CopG (5-42)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10462.19 Da
• Isoelectric Point: 10.0435

>T242524 WP_003083773.1 NZ_CP095774:c147657-147376 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Nucleotide

• Length: 282 bp

>T242524 NZ_OW706648:c2971947-2971549 [Salmonella enterica subsp. enterica serovar Typhi]
ATGCTGAAATTCATGCTTGATACCAATACTTGTATTTTCACCATCAAAAATAAGCCCGAACACATCAGAGAACGCTTCAA
CCTCAATACATCCCGAATGTGTATCAGCTCCATCACCTTAATGGAGCTGATTTACGGTGCTGAAAAAAGCCTGGCACCGG
AGCGTAATTTTGCAGTCGTGGAGGGATTTATCTCCCGCCTTGAGGTTCTGGATTACGATACACAGGCAGCGATACATACC
GGTCAAATCCGTACCGAACTGGCCCGCAAGGGAACACCTGTCGGGTCTTATGACCAGATGATTGCTGGCCATGCCCGTAG
CCGCGGACTGGTCGTCGTCACAAACAATCTCCGCGAGTTTGAACGCATTCCGGGTATCCGAATCGAAGACTGGTGCTAA

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8556.58 Da
• Isoelectric Point: 5.5740

>AT242524 WP_003083775.1 NZ_CP095774:c147881-147654 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Nucleotide

• Length: 228 bp

>AT242524 NZ_OW706648:c2972174-2971947 [Salmonella enterica subsp. enterica serovar Typhi]
ATGCACACAACACTTTTTTTTAGTAACCGGACCCAGGCAGTCAGATTGCCTAAATCGATATCCTTTCCGGAGGATGTGAA
ACATGTCGAAATCATTGCGGTTGGTAGAAGCAGAATCATTACTCCAGTCGGAGAATCCTGGGACAGCTGGTTCGATGGCG
AAGGCGCCAGTACTGATTTTATGAGCACCAGAGAACAACCCGCAGTACAGGAACGGGAAGGATTCTGA

Structures

Toxin

• PDB: 6XRW

Antitoxin

• AlphaFold DB: A0A1C7BDS9