Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 5860768..5861382 Replicon chromosome
Accession NZ_CP095770
Organism Pseudomonas aeruginosa strain 34Pae36

Toxin (Protein)


Gene name hicA Uniprot ID A6VBH9
Locus tag MX654_RS28165 Protein ID WP_071534354.1
Coordinates 5861200..5861382 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A140SDX7
Locus tag MX654_RS28160 Protein ID WP_012077229.1
Coordinates 5860768..5861172 (-) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MX654_RS28135 5856908..5857618 + 711 WP_012074129.1 hypothetical protein -
MX654_RS28140 5857615..5858535 + 921 WP_012074128.1 hypothetical protein -
MX654_RS28145 5858532..5859071 + 540 WP_012074127.1 hypothetical protein -
MX654_RS28150 5859071..5859769 + 699 WP_033896049.1 hypothetical protein -
MX654_RS28155 5859754..5860725 + 972 WP_012077228.1 hypothetical protein -
MX654_RS28160 5860768..5861172 - 405 WP_012077229.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
MX654_RS28165 5861200..5861382 - 183 WP_071534354.1 type II toxin-antitoxin system HicA family toxin Toxin
MX654_RS28170 5861925..5862857 - 933 WP_003120918.1 ZIP family metal transporter -
MX654_RS28175 5862876..5863487 - 612 WP_003098862.1 superoxide dismutase -
MX654_RS28180 5863500..5863949 - 450 WP_003094369.1 hypothetical protein -
MX654_RS28185 5863977..5865353 - 1377 WP_003098863.1 class II fumarate hydratase FumC -
MX654_RS28190 5865346..5865741 - 396 WP_003162782.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 5823888..5861382 37494


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-127)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6702.74 Da        Isoelectric Point: 10.4826

>T242522 WP_071534354.1 NZ_CP095770:c5861382-5861200 [Pseudomonas aeruginosa]
MRSREVIDLLLEDGWYEVAVKGSHHQFKHPSKPGKVTVQHPSSTIPKGTLNNILKQAGLK

Download         Length: 183 bp

>T242522 NZ_OW706648:2394143-2394361 [Salmonella enterica subsp. enterica serovar Typhi]
ATGTCTGATAAACCATTAACTAAAACTGATTATTTGATGCGTTTACGGCGCTGTCAGACAATTGACACTCTGGAGCGCGT
CATTGAGAAAAATAAATATGAATTGTCCGACAATGAGCTGGCTGTATTTTACTCAGCTGCGGATCACCGTCTTGCAGAAT
TGACGATGAACAAACTCTACGACAAGATCCCCTCTTCAGTATGGAAATTCATTCGTTAA

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14670.54 Da        Isoelectric Point: 4.4315

>AT242522 WP_012077229.1 NZ_CP095770:c5861172-5860768 [Pseudomonas aeruginosa]
MKFPVVLHKDPDSDYGVTVPDVPGCFSAGATVSEALANVEEALALHFEGLVTDGEELPQPQDVDAHMKNPDFEGGVWAVV
DFDVTPYLGKAVRFNATLPEHLLQRIDERVKVDKRYQSRSGFLATAAMRELSVA

Download         Length: 405 bp

>AT242522 NZ_OW706648:2393741-2394115 [Salmonella enterica subsp. enterica serovar Typhi]
ATGGACGAATACTCACCCAAAAGACATGATATAGCACAGCTTAAATTTCTTTGCGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGCAACCATGGCTGGGTTAATGACCCGACCTCAGCAGTCAACCTGCAGCTCAATGAGCTGATAGAGC
ATATTGCAACTTTCGCGCTTAATTATAAAATTAAGTACAATGAAGACAATAAATTGATTGCGCAGATAGATGAATACCTG
GACGACACCTTTATGTTGTTCAGCAGCTATGGTATTAATACGCAGGATTTGCAAAAATGGCGTAAATCGGGCAACCGCCT
GTTCCGTTGTTTCGTCAACGCCACCAGGGCTAATCCTGTTAGTTTGTCTTGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6VBH9

Antitoxin

Source ID Structure
AlphaFold DB A0A140SDX7

References