Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 2884441..2884957 Replicon chromosome
Accession NZ_CP095770
Organism Pseudomonas aeruginosa strain 34Pae36

Toxin (Protein)


Gene name relE Uniprot ID A0A3R8UIH5
Locus tag MX654_RS14135 Protein ID WP_025297453.1
Coordinates 2884676..2884957 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A3R8UIM7
Locus tag MX654_RS14130 Protein ID WP_025297454.1
Coordinates 2884441..2884686 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MX654_RS14110 2879563..2879892 - 330 WP_031692728.1 hypothetical protein -
MX654_RS14115 2880240..2880908 + 669 WP_071534660.1 hypothetical protein -
MX654_RS14120 2880905..2882011 + 1107 WP_025297456.1 XRE family transcriptional regulator -
MX654_RS14125 2882142..2884283 + 2142 WP_025297455.1 hypothetical protein -
MX654_RS14130 2884441..2884686 + 246 WP_025297454.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
MX654_RS14135 2884676..2884957 + 282 WP_025297453.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MX654_RS14140 2885363..2885944 - 582 WP_033895412.1 plasmid pRiA4b ORF-3 family protein -
MX654_RS14145 2885958..2886833 - 876 WP_033895413.1 WYL domain-containing protein -
MX654_RS14150 2886962..2888542 + 1581 WP_063837559.1 DNA recombination protein RmuC -
MX654_RS14155 2888566..2888958 + 393 WP_227274803.1 hypothetical protein -
MX654_RS14160 2888942..2889214 + 273 WP_227274804.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2859941..2935400 75459


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-81)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(10-71)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10824.61 Da        Isoelectric Point: 10.6249

>T242519 WP_025297453.1 NZ_CP095770:2884676-2884957 [Pseudomonas aeruginosa]
MTYELEFLPSALKEWQKLGHTVREQIKKKLRERLDNPKVQADALRDMPGHYKIKLRASGYRLVYRVEDERVVVVVVAVGK
RERGAAYQSAKGR

Download         Length: 282 bp

>T242519 NZ_OW706512:3936595-3936879 [Salmonella enterica subsp. enterica serovar Typhi]
ATGACTTATGAACTGGAATTCGACCCGAGGGCCTTAAAAGAGTGGCATAAGCTGGGCGATACGGTGAAGGCTCAGCTTAA
GAAAAAGTTGGCTGATGTGCTATTGAACCCCAGAATCGACTCTGCCCGTTTAAACGGTCTTCCTGACTGCTATAAAATTA
AGCTTAAATCGTCCGGTTATCGTCTGGTGTACCAGGTTCGGGATGACGTTGTGATTGTGTTTGTTGTTGCGGTCGGCAAG
CGAGAACATTCAGCCGTCTATCACGATGCAAACAAACGGCTTTAG

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 8797.21 Da        Isoelectric Point: 4.2550

>AT242519 WP_025297454.1 NZ_CP095770:2884441-2884686 [Pseudomonas aeruginosa]
MQSILADVAVSVSELKKNPSGILAGAGGMPVAVLNHNRVMGYMVPAELYEQMMERLDDLELVEIVKARSGEESVPVRLDD
L

Download         Length: 246 bp

>AT242519 NZ_OW706512:3936363-3936605 [Salmonella enterica subsp. enterica serovar Typhi]
ATGGCCACGCTGAACGTCCGTCTGGATGACAAACTCAAAAATGAGGCTTATGCCGTGCTGGAAAAACTGAACATTACTCC
AACGGAAGCCGTGCGATTACTGTTCCAGTACGTCGCGGAAACGGGGCGCATGCCAGTGAAAACCGTCACTCTTAGCGACA
GTGAAGATGCACTGATTCAGACAGTTCGGGAGAGGCTGTCTAGTCCGCAAAAGGGAATCAAGGTTAGTCTGGATGACTTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3R8UIH5

Antitoxin

Source ID Structure
AlphaFold DB A0A3R8UIM7

References