Detailed information of TA system TA242516

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RHH(antitoxin)
• Location: 162391..162896
• Replicon: chromosome
• Accession: NZ_CP095770
• Organism: Pseudomonas aeruginosa strain 34Pae36

Toxin (Protein)

• Gene name: parE
• Uniprot ID: V6A7K8
• Locus tag: MX654_RS00795
• Protein ID: WP_003083773.1
• Coordinates: 162391..162672 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: A0A1C7BDS9
• Locus tag: MX654_RS00800
• Protein ID: WP_003083775.1
• Coordinates: 162669..162896 (-)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MX654_RS00770	157642..158991	+	1350	WP_003142411.1	C4-dicarboxylate transporter DctA	-
MX654_RS00775	159040..159726	+	687	WP_003083762.1	FadR/GntR family transcriptional regulator	-
MX654_RS00780	159827..160561	+	735	WP_004346926.1	GntR family transcriptional regulator	-
MX654_RS00785	160741..161151	+	411	WP_003101225.1	aegerolysin family protein	-
MX654_RS00790	161183..162091	-	909	WP_003083769.1	LysR family transcriptional regulator	-
MX654_RS00795	162391..162672	-	282	WP_003083773.1	type II toxin-antitoxin system toxin ParE	Toxin
MX654_RS00800	162669..162896	-	228	WP_003083775.1	CopG family ribbon-helix-helix protein	Antitoxin
MX654_RS00805	163072..163692	-	621	WP_003101226.1	hypothetical protein	-
MX654_RS00810	163793..164293	+	501	WP_003101228.1	LEA type 2 family protein	-
MX654_RS00815	164366..164707	+	342	WP_003101229.1	zinc ribbon domain-containing protein YjdM	-
MX654_RS00820	164789..166216	-	1428	WP_003083784.1	GABA permease	-
MX654_RS00825	166385..167878	-	1494	WP_003083788.1	CoA-acylating methylmalonate-semialdehyde dehydrogenase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-87)

Antitoxin

• Ribbon-helix-helix protein, CopG (5-42)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10462.19 Da
• Isoelectric Point: 10.0435

>T242516 WP_003083773.1 NZ_CP095770:c162672-162391 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Nucleotide

• Length: 282 bp

>T242516 NZ_OW706512:3301655-3302140 [Salmonella enterica subsp. enterica serovar Typhi]
GTGGGACGTGTAACAGCACCAGAACCTTTGTCCGCTTTTCATCAGGTAGCTGAGTTCGTCAGCGGTGAAGCTGTGCTCGA
TGACTGGTTGAAGCAAAAGGGCCTCAAAAACCAGGCTCTCGGAGCGGCCAGAACATTTGTGGTGTGCAAGAAAGACACGA
AGCAAGTAGCCGGTTTTTACTCTCTGGCCACCGGTAGCGTCAACCATACAGAAGCGACAGGCAACCTTCGGCGTAACATG
CCAGATCCCATCCCTGTCATTATACTTGCCCGTCTTGCTGTCGATCTCTCATTCCATGGAAAAGGGCTTGGGGCTGATTT
ACTTCATGATGCAGTGCTTCGTTGCTATCGGGTTGCCGAGAATATTGGTGTACGTGCAATCATGGTTCATGCACTTACCG
AAGACGCCAAAAATTTCTACATTCACCATGGTTTCAAATCATCACAAACTCAGCAGCGAACATTGTTCCTTAGGCTCCCT
CAATAG

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8556.58 Da
• Isoelectric Point: 5.5740

>AT242516 WP_003083775.1 NZ_CP095770:c162896-162669 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Nucleotide

• Length: 228 bp

>AT242516 NZ_OW706512:3301380-3301667 [Salmonella enterica subsp. enterica serovar Typhi]
ATGCTATACAAGGGGTGTCTCATGAAATCAGATGTTCAACTTAACCTTAGAGCTAAGGAGTCGCAGCGGGCGCTCATTGA
TGCAGCTGCGGAAATCCTTCACAAGTCACGTACAGATTTCATTCTGGAAACGGCCTGCCGGGCTGCCGAGAATGTGATCC
TTGACCGCCGTGTATTTAACTTTAACGATGAGCAATATGAGGAGTTCATCAATCTGCTTGATGCACCGGTCGCAGATGAT
CCCGTTATCGAAAAACTGCTGGCAAGGAAACCTCAGTGGGACGTGTAA

Structures

Toxin

• PDB: 6XRW

Antitoxin

• AlphaFold DB: A0A1C7BDS9