Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /SpoIISA(toxin)
Location 2511190..2512168 Replicon chromosome
Accession NZ_CP095767
Organism Bacillus cereus strain CDHWZ7

Toxin (Protein)


Gene name spoIISA Uniprot ID B7IX38
Locus tag MYW48_RS12765 Protein ID WP_000624981.1
Coordinates 2511190..2511927 (+) Length 246 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID B7IX39
Locus tag MYW48_RS12770 Protein ID WP_000237817.1
Coordinates 2512040..2512168 (+) Length 43 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MYW48_RS12735 (MYW48_12735) 2506783..2507190 + 408 WP_000072495.1 VOC family protein -
MYW48_RS12740 (MYW48_12740) 2507532..2508314 + 783 WP_106082467.1 class I SAM-dependent methyltransferase -
MYW48_RS12745 (MYW48_12745) 2508469..2509314 - 846 Protein_2436 thiamine pyrophosphate-dependent enzyme -
MYW48_RS12750 (MYW48_12750) 2509290..2509418 - 129 WP_106082469.1 hypothetical protein -
MYW48_RS12755 (MYW48_12755) 2509566..2510048 + 483 WP_000191905.1 MarR family winged helix-turn-helix transcriptional regulator -
MYW48_RS12760 (MYW48_12760) 2510214..2510951 + 738 WP_247727938.1 2,3-diphosphoglycerate-dependent phosphoglycerate mutase -
MYW48_RS12765 (MYW48_12765) 2511190..2511927 + 738 WP_000624981.1 type II toxin-antitoxin system SpoIISA family toxin Toxin
MYW48_RS12770 (MYW48_12770) 2512040..2512168 + 129 WP_000237817.1 hypothetical protein Antitoxin
MYW48_RS12775 (MYW48_12775) 2512241..2512417 + 177 WP_000852629.1 stage II sporulation protein SB -
MYW48_RS12780 (MYW48_12780) 2512436..2512825 - 390 WP_000712655.1 YxeA family protein -
MYW48_RS12785 (MYW48_12785) 2513037..2514506 + 1470 WP_000287540.1 beta-Ala-His dipeptidase -
MYW48_RS12790 (MYW48_12790) 2514819..2515628 + 810 WP_000678376.1 papain-like cysteine protease family protein -
MYW48_RS12795 (MYW48_12795) 2515654..2516259 + 606 WP_000527413.1 hypothetical protein -
MYW48_RS12800 (MYW48_12800) 2516400..2516651 - 252 WP_000821942.1 LuxR C-terminal-related transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(10-243)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 246 a.a.        Molecular weight: 28335.09 Da        Isoelectric Point: 8.2998

>T242515 WP_000624981.1 NZ_CP095767:2511190-2511927 [Bacillus cereus]
MISNIRIGLFVLAIVFVVLVFFYWKNEELYEEKKQRIRKTWYGLFIISVTVYFMIKGIDLTLWKNLLMFTAMVIFVDIAF
ILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTTIIQNVNPAVFGTMEWHTEEEYTKSLNVFLDSYGEKIGAKI
VVFEAAKELNTNFRGIRSQFSIIVPLEHIEQLNEQKAVQVENVGIIPAKIVSDVFIVIDGKKNNLQDRDFENVYNLTIHH
SYFSK

Download         Length: 738 bp

>T242515 NZ_OW706512:2996539-2996850 [Salmonella enterica subsp. enterica serovar Typhi]
GTGCATGTTATCAGCCGAAAACTGTTCAATGAAGCGATGCTCATGTATCCAAACCATGAGCTTGCTCTCACTGAGTTGCT
GAATGTTCTGGAGAAAAAAACATTCACTCAGCCTGAAGAGATGAAGCGGTATATTCCTTCGCTGGATAATTTTAAGTACA
GAGATAAATGGTGGGTGATTGATGTTTCTGGTAACAGCCTGAGACTCATTTCCTACATAGATTTCAGGTTACATAAGATA
TTTGTGAAACATATCGTTTCCCATGCCGAATATGACAAACTGACCGCATATTATCGGGGTAATGAAGAATGA

Antitoxin


Download         Length: 43 a.a.        Molecular weight: 4981.37 Da        Isoelectric Point: 3.9150

>AT242515 WP_000237817.1 NZ_CP095767:2512040-2512168 [Bacillus cereus]
VVKDYDNDFFKEDNEDTTDFSLIKGDALQQVEELEEELKRKS

Download         Length: 129 bp

>AT242515 NZ_OW706512:2996847-2997293 [Salmonella enterica subsp. enterica serovar Typhi]
ATGAGAACTCATCGTCAGATGGATGCAACCAGCGCAAAAAAGATCGTTGATACCTTCAGCGATGCGGTAAAAAGCGTCCC
ACTGATGGGGGAAGACCGAAATGACAATGAGTATCGCAGGGCACTAGCGCTAGTGGAGTTTCTGGTCGACCACGACGATC
TTGAAAACCCACTATTTGAATTGCTCTGTGCCCGAATCAGTGAATACGAAAAACATGCGCCGGAATTCAAAGCACTCAAC
CAACACCTGGAGAAAACGCCCCCTGGCGTTTCAGTATTGCGAACGCTCATGGATCAATACGGTCTCAAAGCAGCAGATCT
TGCCAACGAACTTGGTTCTAAATCGAACGTCAGCAACATCTTAAATGGCCGCAGAGCACTAACGGTTAATCATATTAAAG
CGCTTACACAACGCTTTAAACTACCAGCGGATGCCTTCATCGAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6D1SWF1

Antitoxin

Source ID Structure
AlphaFold DB B7IX39

References